The combined contraceptive vaginal ring (NuvaRing®) and lipid metabolism: a comparative study

Tuppurainen, Marjo; Klimscheffskij, R.; Venhola, Mika; Dieben, T. O. M.

doi:10.1016/j.contraception.2004.01.004

Cited by 47 publications

(29 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the study conducted by Tuppurainen et al (2004), (22) it was found that the total HDL and LDL cholesterol level remained unchanged while triglyceride level increased from baseline from CCVR use. In our study, median percentage change from baseline values was total cholesterol 0.9%, HDL cholesterol-1.3%, LDL cholesterol 0.2% and triglyceride 20.1%.…”

Section: Resultsmentioning

confidence: 99%

To Study the Acceptability and Efficacy of Combined Contraceptive Vaginal Ring Amidst Indian Women

Dam¹,

Paul²,

Banerjee³

et al. 2015

jemds

View full text Add to dashboard Cite

OBJECTIVES:To study the efficacy, and acceptability and reasons for discontinuity of CCVRs in Indian women along with cycle control, safety aspects, local and systemic adverse effects, chances of spontaneous expulsion and partner compliance. METHODS: This interventional longitudinal study included 45 married women aged between 18-45 years seeking reversible means of contraception but with no history of usage of any form of hormonal contraceptives in the previous 6 months. The outcome variables were measured in terms of contraceptive efficacy, cycle regularity, systemic effects on blood pressure, liver function, body weight, lipid parameters and blood sugar along with local effect on cervix and vagina. Patient compliance, acceptability and spouse compliance was also measured by questionnaires. RESULTS: In this study there were no unwanted pregnancies in women amongst 117 exposed cycles. The incidence of intended bleeding pattern was 95%, the effect of CCVR on liver function, blood pressure, etc. was not clinically relevant. It was not associated with an increased risk of cervical or vaginal abnormalities, 96% women were satisfied with the ring usage and 97% would recommend it to others, 70% of women and 82% of their partners never/ rarely felt the ring during intercourse. CONCLUSION: From the present study, it can be concluded that CCVR is an effective contraceptive with good cycle control, minimal systemic or local adverse effects along with low incidence of spontaneous expulsion and higher level of user and partner acceptability.

show abstract

Section: Resultsmentioning

confidence: 99%

To Study the Acceptability and Efficacy of Combined Contraceptive Vaginal Ring Amidst Indian Women

Dam¹,

Paul²,

Banerjee³

et al. 2015

jemds

View full text Add to dashboard Cite

show abstract

“…It is important to mention that all the published studies looking at surrogate blood biomarkers either lacked a sufficient sample size or studied the biomarkers within three to six 28-day cycles of use. 11,33,38,39 Our study was limited in various ways. The presented results should be interpreted cautiously and the results not considered definite as the sample size was small, and we did a relatively large number of tests.…”

Section: Discussionmentioning

confidence: 99%

Oral Versus Vaginal Combined Hormonal Contraceptives' Effect on Coagulation and Inflammatory Biomarkers Among Young Adult Women

Divani

Luo

Brandy

et al. 2012

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

In order to compare the effect of combined oral contraceptive (COC) and combined vaginal contraceptive (CVC) methods on the inflammation and procoagulation, we recruited female participants in 3 groups: control participants, COC users, and CVC users. We measured different blood biomarkers. The users of both COC and CVC had higher levels of C-reactive protein (P < .0001) and factor VII (P < .0001). However, CD40 ligand was only higher for COC users (P < .0001) and not the CVC users. Even though the levels of thrombin/antithrombin III were not higher for COC and CVC users, as compared to the controls, CVC users had higher levels as compared to COC users (P ¼ .0327). As compared to the control group, we observed higher levels von Willebrand factor among CVC users but not the COC users. Longitudinal studies with larger sample size are needed to better assess the inflammatory and procoagulation response due to CVC use.

show abstract

“…Because of the increased risk of myocardial infarction, stroke and peripheral artery disease [51] associated with oral contraception, it is advised to prescribe a statin as soon as girls are prescribed contraception. This applies to any form of contraceptive, including vaginal rings, as these are also known to increase ApoB, triglycerides and LDL-C [52]. Because statin teratogenicity remains controversial [53], it is advisable to prescribe contraception in female teenagers who are receiving statins and conversely to prescribe statins in those who are receiving oral contraception.…”

Section: Contraceptionmentioning

confidence: 99%

Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization

et al. 2011

View full text Add to dashboard Cite

a b s t r a c tSince heterozygous familial hypercholesterolemia (HeFH) is a disease that exposes the individual from birth onwards to severe hypercholesterolemia with the development of early cardiovascular disease, a clear consensus on the management of this disease in young patients is necessary. In Belgium, a panel of paediatricians, specialists in (adult) lipid management, general practitioners and representatives of the FH patient organization agreed on the following common recommendations.

show abstract

The combined contraceptive vaginal ring (NuvaRing®) and lipid metabolism: a comparative study

Cited by 47 publications

References 16 publications

To Study the Acceptability and Efficacy of Combined Contraceptive Vaginal Ring Amidst Indian Women

To Study the Acceptability and Efficacy of Combined Contraceptive Vaginal Ring Amidst Indian Women

Oral Versus Vaginal Combined Hormonal Contraceptives' Effect on Coagulation and Inflammatory Biomarkers Among Young Adult Women

Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization

Contact Info

Product

Resources

About