The combined effects of aqueous extract of Ficus sycomorus l. (Moraceae) Stem Bark and Nigella sativa l. (Ranunculaceae) seeds on hematological and biochemical parameters in rabbits

Abstract

The stem bark of Ficus sycomorus and the leaves o N gella sativa were collected; dried and extracted using d stilled water and filter paper, to study the effects of combination of these extracts on hematological and biochemical parameters in rabbits. Twenty rabbits weighing between 1000 and 1,200 g were randomly separated into four groups o five rabbits each. Group A rabbits were injected with Ficus sycomorus (200 mg/kg), group B; N gella sativa (100 mg/kg), group C; combinat on of F. sycomorus (200 mg/kg) and N. sativa (100 mg/kg) while group D rabbits were given distilled water and served as control. Blood (1.2 ml) was collected for analyses of hematological and biochemical parameters using standard methods. Bleeding and clotting times were also measured using ear vein puncture and capillary tube methods respectively. The PCV, Hb and RBC values showed various irregular differences (P < 0.05) due to extracts treatments. The differential leucocytes counts and the biochemical parameters did not show any differences (P > 0.05). The bleeding and clotting times (min.) decreased (P<0.05) due to various extracts treatments compared with non-treated group that was given distilled water. Therefore it was concluded that the extracts either alone or in combination could not affect the peripheral blood adversely and it is non toxic to liver, kidney and muscles as indicated by the biochemical analyses and there was no apparent advantage in combining the two extracts as far as these parameters were concerned. f i i f i i

UPLC-QToF Nanospray MS and NMR Analysis of Ficus sycomorus Stem Bark and Its Effects on Rabbit

“…Conversely, our extract had no effect on the RBC counts and hemoglobin level. A similar result has been reported, where no hematological and biochemical alterations were observed in rabbits injected intraperitoneally with a single or combined dose of extracts of F. Sycomorus stem bark and Nigella sativa [48].…”

Hematological and Histological Effects of Ficus Sycomorus Leaf Extract on Bone Marrow of Phenylhydrazine - Induced Haemolytic Anaemia

“…Generally, the cells appear pale and poorly stained, indicating a decrease in hematopoietic activity but a few areas of erythroid cells/element (white arrows) also indicate cellular recovery/regeneration. These indicate that Ficus sycomorus leaf extract stimulated erythropoiesis in accordance with studies carried out by (Sandabe et al, 2007). However at low dose Ficus sycomorus extract seems not to be effective enough to enhance full recovery from anemia.…”

“…Natives of Aninri Local Government have long used the leaf of this plant traditionally in combination with other plants to treat blood loss cases like malaria induced anemia. Studies carried out by (Sandabe et al, 2007) observed that ficus sycomorus extract can stimulate erythropoiesis in rabbits which is an indication that it may be useful in anemic situations, such as hemolytic anemia. Sycamore is a rich source of minerals e.g.…”

“…These Anemia management modalities increases costs of medical care and lower a person's productivity through a decreased ability to work .Plants have long served as an alternative source of treatment for some diseases. Traditional medicine utilizes ficus sycomorus in treatment of blood loss related (Sandabe et al, 2007). though no evidence has been shown to prove this hence, it is imperative to check the effect of ficus sycomorus extract on experimentally induced hemolytic anemia in albino wister rats, This study investigates the effect of ethanolic extract of ficus sycomorus on Phenylhydrazine-induced hemolytic anemia in albino wister rats.…”

GC-MS Analysis, Antioxidant, Antimicrobial and Anticancer Activities of Extracts from Ficus sycomorus Fruits and Leaves

“…In addition, it is used for the treatment of cough, diarrhea, skin infection, stomach disorders, liver disease, epilepsy, tuberculosis, lactation disorders, helminthiasis, infertility and sterility (Sandabe et al, 2006). The extracts of fruits of F. sycomorus are also used for the treatment of various diseases, such as cough, diarrhea, stomach disorder, skin infections, epilepsy, liver disease, tuberculosis, lactation disorder, infertility and sterility and helminthiasis (Sandabe et al, 2007;Bello et al, 2013). The target plant contains several bioactive chemical constituents.…”