The Combined Effects of Sodium Fluoride and Pyridoxine Hydrochloride: II. in vivo Studies in Animals.

Abstract:A cariostatic effect of soduim fluoride in combination with pyridoxine hydrochloride solution on artificial caries lesion formation was reported previously. The purpose of the present study was to examine the mode of action of this solution on enamel. Intact human enamel was immersed and fluoride in combination with pyridoxine hydrochloride solution, 900ppm of fluoride (F-), pH 4.5-NaFMoreno's demineralizing solution (1974), consisting of 50% hydroxyapatite in saturated lactate buffer (pH 4.5). Distribution of phosphorus, calcium, and fluoride in enamel were determined with line analysis by EPMA, and state analysis was performed to identify the reaction products in fluoride treated enamel.Only Ca and F were detected in fluoride-treated superficial enamel by magnified analysis. Ca and F were also detected in the crystal deposits, and a large amount of calcium fluoride was seen in the NaF+VB6 group. The state analysis with EPMA showed that the reaction products were calcium fluoride and fluorapatite, and the volume of reaction products was very large in the NaF+VB6 group.In EPMA analysis of caries lesions, the fluoride level was higher than in other sound enamel surfaces, and the NaF+ VB6 group showed the highest level of fluoride. Calcium and phosphorus level in the NaF+VB6 group was the same as in the sound enamel layer, and the level was low in the NaF and

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The Combined Effects of Sodium Fluoride and Pyridoxine Hydrochloride: II. in vivo Studies in Animals.

Cited by 2 publications

References 18 publications

Effect of Sodium Fluoride in Combination with Pyridoxine Hydrochloride on the Artificial Caries Lesion Formation.

Effect of Sodium Fluoride in Combination with Pyridoxine Hydrochloride on the Artificial Caries Lesion Formation.

EPMA Analysis of Artificial Caries Lesions on Enamel Treated with Sodium Fluoride in Combination with Pyridoxine Hydrochloride Solution.

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