The Combined Effects of ω -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients

Soveyd, Neda; Abdolahi, Mina; Djalali, Mahmoud; Hatami, Mahsa; Tafakhori, Abbas; Sarraf, Payam; Honarvar, Niyaz Mohammadzadeh

doi:10.2174/1871527317666171213154749

Cited by 40 publications

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“…Each of the ω-3 or nanocorcinoma placebo were similar in color, shape and size and were synthetized by the related pharmaceutical company. The duration of treatment was two months [31].…”

Section: Patients and Supplementationmentioning

confidence: 99%

A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study

Abdolahi

Sarraf

Javanbakht

et al. 2018

CNSNDDT

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“…Each of the ω-3 or nanocorcinoma placebo were similar in color, shape and size and were synthetized by the related pharmaceutical company. The duration of treatment was two months [31].…”

Section: Patients and Supplementationmentioning

confidence: 99%

A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study

Abdolahi

Sarraf

Javanbakht

et al. 2018

CNSNDDT

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“…11 In a clinical trial, nanocurcumin plus omega-3 fatty acids supplementation have been shown to reduce both the attack frequency and the ICAM-1 (adhesion molecule associated with inflammation) serum level in patients with migraine. 12 Therefore, nanoformulations of curcumin have been developed for their superior therapeutic efficiency in inflammatory and oxidative stress processes. 13,14 The serotoninergic system represents one of the most important pathophysiological mechanisms of migraine; 5-hydroxytryptamine1 (5-HT1) receptor agonists are known to be effective in the treatment of migraine attacks.…”

Section: Introductionmentioning

confidence: 99%

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Bulboacă¹,

Bolboacă²,

Stănescu³

et al. 2018

IJN

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BackgroundCurcumin has antioxidative properties that could be useful in various diseases due to its ability to act on multiple targets of various cellular pathways. We aimed to assess the efficacy of liposomal curcumin compared with curcumin solution, when in addition to sumatriptan (ST) treatment, in an experimental migraine model induced with nitroglycerin (NTG) in rats.MethodsSeven groups of 9 rats each were investigated: control group without migraine (1 mL saline solution intraperitoneal injection [ip]), control group with induced migraine, NTG+ST group (ST), NTG+ST+curcumin1 (CC1) group – 1 mg/100 g body weight (bw), NTG+ST+CC2 – 2 mg/100 g bw, NTG+ST+liposomal curcumin1 (lCC1) group – 1 mg/100 g bw, and NTG+ST+lCC2 (lCC2) group – 2 mg/100 g bw. NTG and ST were administered as 1 mL ip NTG | 1 mg/100 g bw and 1 mL ip ST | 1 mg/100 g bw, respectively. Plasma total oxidative stress (TOS), malondialdehyde (MDA), nitric oxide (NOx), thiol levels, as well as total antioxidative capacity (TAC) were assessed. The nociception process was assessed by counting the number of flinches and shakes after the formalin test.ResultsThe plasma TOS, MDA, and NOx levels, as oxidative stress parameters, were significantly decreased in the curcumin-treated groups, especially where curcumin was in liposomal form. The thiol and TAC were also improved by the curcumin treatment, with the best results obtained for the liposomal curcumin. The closest number of flinches and shakes to the control group was obtained for the group treated with liposomal curcumin at a dose of 2 mg/100 g bw.ConclusionLiposomal curcumin in a dose of 2 mg/100 g bw when in addition to ST treatment could be an optimum therapeutic strategy for migraine attacks and could represent a base for future clinical research and application.

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“…Combining fish oil with curcumin for additional benefits is a very new approach; clinical trials are limited, with inconsistent results [ 14 , 26–28 ], and effects on OA pain relief have not yet been tested. In migraine patients, fish oil and curcumin were found to have synergistic effects on reduction of inflammatory markers [ 26 , 27 ] and migraine attack frequency [ 27 ]. However, in people at high risk of developing type 2 diabetes, the combination did not result in any complementary effects on glycaemic control and blood lipids [ 28 ], and in our study we did not find any synergistic effects on cardiometabolic risk factors and cerebrovascular function [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity

Kuszewski

Wong

Howe

2020

Rheumatology Advances in Practice

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Objectives Osteoarthritis (OA) is a leading cause of chronic pain and disability. Next to inflammation, vascular pathology has been hypothesised to play a role in its etiology and progression. Due to side effects and low efficacy of pharmacological treatments, dietary supplements are popular as alternative treatments, but evidence of efficacy is limited. We tested whether fish oil and curcumin supplementation can reduce chronic pain and OA burden in older adults. Methods A 16-week randomized, double-blind, placebo-controlled, 2x2 factorial design supplementation trial with fish oil (2000mg docosahexaenoic acid + 400mg eicosapentaenoic acid/day), curcumin (160mg/day) or a combination of both was undertaken in sedentary overweight/obese older adults. Secondary outcomes included treatment changes in self-reported chronic pain and OA burden and whether changes are related to changes in small artery elasticity (surrogate marker for microvascular function), C-reactive protein (inflammatory marker) and well-being. Results The majority of participants (131/152) reported chronic pain, which was predominantly OA-specific. Fish oil significantly reduced OA-specific pain (P = 0.002, Cohen’s d = 0.56) and burden (P = 0.015, Cohen’s d = 0.45) compared to no fish oil treatment; reductions correlated with improvements in microvascular function and well-being. Curcumin, alone or in combination with fish oil, did not reduce pain measures. Conclusion Our findings indicate potential for fish oil to alleviate OA pain and burden in overweight/obese older adults. Further investigations should be undertaken in patients with clinically diagnosed OA to evaluate fish oil alone and as an adjunct to conventional pharmacotherapy and to investigate underlying mechanisms.

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The Combined Effects of ω -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients

Cited by 40 publications

References 0 publications

A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study

A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity

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