The combined impact of Type D personality and depression on cardiovascular events after acute myocardial infarction

Abstract

Background Type D personality and depression are the independent psychological risk factors for adverse outcomes in cardiovascular patients. The aim of this study was to examine the combined effect of Type D personality and depression on clinical outcomes in patients suffering from acute myocardial infarction (AMI). Methods This prospective cohort study included 3568 patients diagnosed with AMI between February 2017 and September 2018. Type D personality and depression were assessed at baseline, while the major adverse cardiac event (MACE) rate (cardiac death, recurrent non-fatal myocardial infarction, revascularization, and stroke) and in-stent restenosis (ISR) rate were analyzed after a 2-year follow-up period. Results A total of 437 patients developed MACEs and 185 had ISR during the follow-up period. The Type D (+) depression (+) and Type D (+) depression (−) groups had a higher risk of MACE [95% confidence interval (CI) 1.74–6.07] (95% CI 1.25–2.96) and ISR (95% CI 3.09–8.28) (95% CI 1.85–6.22). Analysis of Type D and depression as continuous variables indicated that the main effect of Type D, depression and their combined effect were significantly associated with MACE and ISR. Moreover, Type D (+) depression (+) and Type D (+) depression (−) emerged as significant risk factors for MACE and ISR in males, while only Type D (+) depression (+) was associated with MACE and ISR in female patients. Conclusions These findings suggest that patients complicated with depression and Type D personality are at a higher risk of adverse cardiovascular outcomes. Individual assessments of Type D personality and depression, and comprehensive interventions are required.

The antidepressant effect of Shexiang Baoxin Pills on myocardial infarction rats with depression may be achieved through the inhibition of the NLRP3 inflammasome pathway

“…Subsequently, a followup period of 2 years was implemented to analyze the occurrence of MACE. The findings from this investigation revealed a higher incidence of MACE among individuals presenting both Type D personality traits and depression (Wang et al, 2023). Furthermore, a meta-analysis published in 2011 was conducted to investigate the association between depression and mortality rates in patients who had experienced a MI.…”

Inventory Path Optimization of VMI Large Logistics Enterprises Based on Ant Colony Algorithm

“…While cultural errors have traditionally been used to develop solutions, it has shifted very quickly and even erratically. e main reason for this is that it uses a random selection strategy when running the solution [24]. To prevent this from happening, we need to improve the ant colony algorithm to dynamically modify the build results during the creation process and accept the option of combining algorithms, fully and randomly choosing the creation method.…”

Clinical and psychological correlations with type D personality in patients with chronic coronary syndrome

“…Более всего в этом плане изучены сердечно-сосудистые заболевания; именно при этих заболеваниях и был впервые выявлен и предложен для клинического использования данный тип личности [13]. Дальнейшие исследования внесли некоторые уточнения в прогностическое влияние типа личности Д: подтверждено негативное влияние на прогноз у больных ишемической болезнью сердца (ИБС) и у пациентов более молодого возраста [14,15] и не выявлено такового при хронической сердечной недостаточности (ХСН) и у лиц старших возрастных групп [16]. Неблагоприятное влияние на прогноз у больных ИБС с типом личности Д заставляет задуматься как о возможных механизмах, через которые этот прогноз реализуется, так и о путях коррекции данного влияния.…”