The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament

Lee, Chun-Yi; Liu, Xuhui; Smith, Carolyn L.; Zhang, Xiaoliu; Hsu, Horng‐Chaung; Wang, Der-Yean; Luo, Zong‐Ping

doi:10.1016/j.matbio.2004.07.004

Cited by 83 publications

(84 citation statements)

References 28 publications

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“…To our knowledge, the effect of ERT on tendon FSR has not been measured before, but the present results are in concert with observations showing a stimulating effect of estradiol on the expression of CTX-I in porcine ACL (32) and in pelvic connective tissue in human and rhesus macaques (10,15). The stimulating effect of estradiol on tendon collagen synthesis in the resting state was further supported by a positive correlation between s-estradiol and tendon collagen synthesis.…”

Section: Tendon Synthesissupporting

confidence: 88%

“…A smaller tendon diameter has been observed in postmenopausal female golf players who used hormone replacement therapy compared with controls (11). Furthermore, an inhibition of CTX-I expression has been demonstrated when estradiol and tensile loading of ACL fibroblasts were combined, despite the fact that both stimuli upregulated the expression of CTX-I when applied separately (32). These findings suggest a differential effect of estrogen in bone and tendons and estrogen in combination with mechanical loading.…”

mentioning

confidence: 97%

“…Estrogen receptors have been localized in ligaments (32,33), and tendons express transcripts for estrogen receptors (23). Nevertheless, the effect of estrogen on tendon and ligament turnover is not clarified.…”

mentioning

confidence: 99%

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Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

Hansen

Kongsgaard²,

Holm³

et al. 2009

Journal of Applied Physiology

121

114

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Flyvbjerg A, Langberg H, Kjaer M. Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women. J Appl Physiol 106: 1385-1393, 2009. First published October 16, 2009 doi:10.1152/japplphysiol.90935.2008.-The knowledge about the effect of estradiol on tendon connective tissue is limited. Therefore, we studied the influence of estradiol on tendon synthesis, structure, and biomechanical properties in postmenopausal women. Nonusers (control, n ϭ 10) or habitual users of oral estradiol replacement therapy (ERT, n ϭ 10) were studied at rest and in response to one-legged resistance exercise. Synthesis of tendon collagen was determined by stable isotope incorporation [fractional synthesis rate (FSR)] and microdialysis technique (NH2-terminal propeptide of type I collagen synthesis). Tendon area and fibril characteristics were determined by MRI and transmission electron microscopy, whereas tendon biomechanical properties were measured during isometric maximal voluntary contraction by ultrasound recording. Tendon FSR was markedly higher in ERT users (P Ͻ 0.001), whereas no group difference was seen in tendon NH2-terminal propeptide of type I collagen synthesis (P ϭ 0.32). In ERT users, positive correlations between serum estradiol (sestradiol) and tendon synthesis were observed, whereas change in tendon synthesis from rest to exercise was negatively correlated to s-estradiol. Tendon area, fibril density, fibril volume fraction, and fibril mean area did not differ between groups. However, the percentage of medium-sized fibrils was higher in ERT users (P Ͻ 0.05), whereas the percentage of large fibrils tended to be greater in control (P ϭ 0.10). A lower Young's modulus (GPa/%) was found in ERT users (P Ͻ 0.05). In conclusion, estradiol administration was associated with higher tendon FSR and a higher relative number of smaller fibrils. Whereas this indicates stimulated collagen turnover in the resting state, collagen responses to exercise were negatively associated with s-estradiol. These results indicate a pivotal role for estradiol in maintaining homeostasis of female connective tissue. connective tissue; tendon fibrils; insulin-like growth factor-I; extracellular matrix; bone CROSS-SECTIONAL FINDINGS INDICATE that sex hormones influence tendon biomechanical properties (36), extracellular matrix adaptability in response to mechanical loading (11,21,36,41,59), and the risk of sustaining soft tissue injuries (11,24,25).Estrogen receptors have been localized in ligaments (32, 33), and tendons express transcripts for estrogen receptors (23). Nevertheless, the effect of estrogen on tendon and ligament turnover is not clarified. Thus an inhibiting effect (34, 60), no effect (51), and a stimulating effect (32) on collagen synthesis and fibroblast proliferation in vitro have been observed in anterior cruciate ligament (ACL) tissue samples. These contrasting findings are probably related to the variation between animal species and the applied methods. This ...

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Section: Tendon Synthesissupporting

confidence: 88%

mentioning

confidence: 97%

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Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

Hansen

Kongsgaard²,

Holm³

et al. 2009

Journal of Applied Physiology

121

114

View full text Add to dashboard Cite

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“…In the collagen production law (Eq. (12)), the exponent may be estimated to α = 3.0 (Lee et al, 2004). There are two parameters that are difficult to estimate, namely the life-time t cl of the collagen fibres and the pre-stretch λ pre of collagen fibres.…”

Section: Geometrical and Physical Parametersmentioning

confidence: 99%

“…Furthermore, the activity of adherent cells is strongly dependent upon mechanical stimuli from the surrounding ECM (Pelham and Wang, 1997;Weyts et al, 2003). More specifically, cyclic deformation (which fibroblasts embedded in an arterial wall are exposed to) is known to influence the proliferation and collagen production rate of fibroblasts (Butt et al, 1995;Eastwood et al, 1998;Lee et al, 2004;Wille et al, 2006;Wu and Chen, 2000), and both of these factors are important for the growth of aneurysmal tissue.…”

mentioning

confidence: 99%

A theoretical model for fibroblast-controlled growth of saccular cerebral aneurysms

Kroon

Holzapfel

2009

Journal of Theoretical Biology

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A new theoretical model for the growth of saccular cerebral aneurysms is proposed by extending the recent constitutive framework of Kroon and Holzapfel (J. Theor. Biol., 247:775-787, 2007). The continuous turnover of collagen is taken to be the driving mechanism in aneurysmal growth. The collagen production rate depends on the magnitude of the cyclic deformation of fibroblasts, caused by the pulsating blood pressure during the cardiac cycle. The volume density of fibroblasts in the aneurysmal tissue is taken to be constant throughout the growth process. The growth model is assessed by considering the inflation of an axisymmetric membranous piece of aneurysmal tissue, with material characteristics representative of a cerebral aneurysm. The diastolic and systolic states of the aneurysm are computed, together with its load-free state. It turns out that the value of collagen pre-stretch, that determines growth speed and stability of the aneurysm, is of pivotal importance. The model is able to predict aneurysms with typical berry-like shapes observed clinically, and the predicted wall stresses correlate well with the experimentally obtained ultimate stresses of this type of tissue. The model predicts that aneurysms should fail when reaching a size of about 1.2-3.6 mm, which is smaller than what has been clinically observed. With some refinements, the model may, however, be used to predict future growth of diagnosed aneurysms.

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Incidence of Total Knee and Hip Replacement for Osteoarthritis in Relation to Circulating Sex Steroid Hormone Concentrations in Women

Hussain

Cicuttini

Bell

et al. 2014

Arthritis & Rheumatology

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Objective. The increased prevalence of osteoarthritis (OA) in postmenopausal women suggests that changes in either circulating sex steroid concentrations or the tissue response to sex steroids may have a role in the pathogenesis of OA. The aim of this study was to examine whether circulating sex steroid concentrations are associated with the incidence of total knee and total hip replacement for OA. Conclusion. A lower estradiol concentration is a risk factor for knee OA, while a lower androstenedione concentration and higher SHBG concentration are risk factors for hip OA in women. These findings suggest that circulating sex steroids have a role in the pathogenesis of OA, and that modifying these steroid concentrations may provide a potential strategy for the prevention and treatment of knee and hip OA.Osteoarthritis (OA) is a major health problem associated with significant morbidity and disability, particularly in patients with OA of the knees and hips. In 2010, a total prevalence of 71.1 million years lived with disability was attributed to OA as the cause, an increase of 64% since 1990 (1). Currently, there are no officially

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The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament

Cited by 83 publications

References 28 publications

Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

A theoretical model for fibroblast-controlled growth of saccular cerebral aneurysms

Incidence of Total Knee and Hip Replacement for Osteoarthritis in Relation to Circulating Sex Steroid Hormone Concentrations in Women

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