The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting

Meng, Jing; Shingo, Tetsuro; Yasuhara, Takao; Kondo, Akihiko; Morimoto, T; Wang, Feifei; Baba, Tetsuya; Yuan, Wen; Tajiri, Naoki; Uozumi, Takashi; Murakami, M; Tanabe, Mariko; Miyoshi, Yasuyuki; Date, Isao

doi:10.1016/j.brainres.2009.07.079

Cited by 36 publications

(31 citation statements)

References 43 publications

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“…Ruschenschmidt et al (2005) have demonstrated that embryonic stem cell-derived neurons display characteristic properties of neurons when transplanted in the hippocampi of chronic epileptic animals. The same grafting technique using striatal precursors, adult neural stem cells or hippocampal stem cells in an acute period of the disease reduced seizure frequency in chronic epilepsy (Hattiangady et al, 2008;Jing et al, 2009;Shen et al, 2010). Choosing a different method of administration, Chu et al (2004) evaluated the effects of intravenously injected neural stem/ progenitor cells on SRS.…”

Section: Discussionmentioning

confidence: 99%

“…Life Sciences j o u r n a l h o m e p a g e : w w w. e l s ev i e r. c o m / l o c a t e / l i f e s c i e Jing et al, 2009;Li et al, 2009b;Ruschenschmidt et al, 2005;Shen et al, 2010;Zaman et al, 2000). Recently, Costa-Ferro et al (2010) showed that bone marrow mononuclear cells (BMMCs) can prevent the development of chronic seizures, reduce neuronal loss, and influence the reorganization of the hippocampal network in the acute phase of experimental epilepsy.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

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Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats

et al. 2011

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“…EPO also significantly enhanced the survival of neural stem cells but did not affect neuronal differentiation or migration [93] .…”

Section: Tissue-protective Effects Of Epomentioning

confidence: 94%

Erythropoietin: A Hormone with Multiple Functions

2011

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Erythropoietin (EPO), the main hemopoietic hormone synthesized by the kidney as well as by the liver in fetal life, is implicated in mammalian erythropoiesis. Production and secretion of EPO and the expression of its receptor (EPO-R) are regulated by tissue oxygenation. EPO and EPO-R, expressed in several tissues, exert pleiotropic activities and have different effects on nonhemopoietic cells. EPO is a cytokine with antiapoptotic activity and plays a potential neuroprotective and cardioprotective role against ischemia. EPO is also involved in angiogenesis, neurogenesis, and the immune response. EPO can prevent metabolic alterations, neuronal and vascular degeneration, and inflammatory cell activation. Consequently, EPO may be of therapeutic use for a variety of disorders. Many tumors express EPO and/or EPO-R, but the action of EPO on tumor cells remains controversial. It has been suggested that EPO promotes the proliferation and survival of cancer cells expressing EPO-R. On the other hand, other reports have concluded that EPO-R plays no role in tumor progression. This review provides a detailed insight into the nonhemopoietic role of EPO and its mechanism(s) of action which may lead to a better understanding of its potential therapeutic value in diverse clinical settings.

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“…It is possible that the introduction of new GABA-synthesizing cells into the inhibitory circuitry of the injured hippocampus underlies the reductions in SRS in this study. In another study, NSCs obtained from the adult subventricular zone (SVZ)-NSCs were expanded in culture as neurospheres, and neurosphere cells were grafted into the rat hippocampus at 1 week after a hippocampal injury induced through a unilateral intracerebroventricular kainic acid administration [83]. This study showed that the KA-treated rats receiving NSC grafts exhibited reduced frequencies of abnormal spikes at 2 to 3 weeks postgrafting in comparison to the KA-treated rats receiving nonspecific grafts, implying that NSC grafting shortly after injury has the ability to decelerate the process of epileptogenesis.…”

Section: Efficacy Of Grafts Of Neural Stem Cells For Easing Injury Ormentioning

confidence: 99%

Progress in Cell Grafting Therapy for Temporal Lobe Epilepsy

Shetty

2011

Neurotherapeutics

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Temporal lobe epilepsy (TLE), exemplified by complex partial seizures, is recognized in~30% of epileptic patients. Seizures in TLE are associated with cognitive dysfunction and are resistant to antiepileptic drug therapy iñ 35% of patients. Although surgical resection of the hippocampus bestows improved seizure regulation in most cases of intractable TLE, this choice can cause lasting cognitive deficiency and reliance on antiepileptic drugs. Thus, alternative therapies that are proficient in both containing the spontaneous recurrent seizures and reversing the cognitive dysfunction are needed. The cell transplantation approach is promising in serving as an adept alternate therapy for TLE, because this strategy has shown the capability to curtail epileptogenesis when used soon after an initial precipitating brain injury, and to restrain spontaneous recurrent seizures and improve cognitive function when utilized after the occurrence of TLE. Nonetheless, this treatment needs further advancement and rigorous evaluation in animal prototypes of chronic TLE before the conceivable clinical use. It is especially vital to gauge the efficacy of distinct donor cell types, such as the hippocampal precursor cells, γ-aminobutyric acid-ergic progenitors, and neural stem cells derived from diverse human sources (including the embryonic stem cells and induced pluripotent stem cells) for longstanding seizure suppression using continuous electroencephalographic recordings for prolonged periods. Additionally, the identification of the mechanisms underlying the graft-mediated seizure suppression and improved cognitive function, and the development of apt grafting strategies that enhance the anti-seizure and procognitive effects of grafts will be necessary. The goal of this review is to evaluate the progress made hitherto in this area and to discuss the prospect for cell-based therapy for TLE.

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The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting

Cited by 36 publications

References 43 publications

Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats

Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats

Erythropoietin: A Hormone with Multiple Functions

Progress in Cell Grafting Therapy for Temporal Lobe Epilepsy

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