The Coming Gray Tide: Wanted: Health Innovations for an Increasingly Older Population

Mertz, Leslie

doi:10.1109/mpul.2016.2647058

Cited by 9 publications

(8 citation statements)

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“…The United States 28 – 31 , 36 and other developed countries 45 , 46 are presently witnessing an increasing incidence of EC, reflecting both an aging population 47 and rising obesity rates. 33 , 48 , 49 …”

Section: Discussionmentioning

confidence: 99%

Postablation Endometrial Carcinoma

Wortman

Vilos

et al. 2017

JSLS

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Background:Many women have undergone both resectoscopic and nonresectoscopic (or global) endometrial ablation (EA) during the past 20 years. These women are now approaching their sixth and seventh decades of life, a time frame in which endometrial carcinoma (EC) is most frequently diagnosed.Database:In several reports, surgeons have expressed concern that endometrial ablation may leave a sequestered island of EC that may escape detection, possibly delaying its diagnosis or causing it to appear at an advanced stage. Others suggest that EA artifact does not hinder the evaluation and treatment planning in the presence of EC. Data bases used are from Medline and PubMed.Discussion:We introduce 6 new cases of postablation endometrial carcinoma (PAEC), 4 of which occurred after the introduction of global endometrial ablation (GEA) techniques. In addition, we examine several key questions regarding the impact of EA on the subsequent development of EC, including the manner in which PAEC presents, the efficacy of traditional diagnostic modalities, the ablation-to-cancer interval, and the stage of PAEC at the time of diagnosis. Finally, we explore the use of reoperative hysteroscopic surgery (RHS) as a diagnostic modality and address the possible role ultrasound surveillance as a screening method for women at risk of EC.

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Section: Discussionmentioning

confidence: 99%

Postablation Endometrial Carcinoma

Wortman

Vilos

et al. 2017

JSLS

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“…Our aging society is contributing to a rapid increase in the number of fractures and prevalence of degenerative changes caused by osteoporosis and osteoarthritis [ 1 , 2 , 3 , 4 , 5 ]. As a result, the need for joint replacement/reconstruction is increasing, with over one million shoulder, elbow, hip, and knee replacements performed annually in the United States alone [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Prolonged Post-Polymerization Biocompatibility of Polymethylmethacrylate-Tri-n-Butylborane (PMMA-TBB) Bone Cement

et al. 2021

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Polymethylmethacrylate (PMMA)-based acrylic bone cement is commonly used to fix bone and metallic implants in orthopedic procedures. The polymerization initiator tri-n-butylborane (TBB) has been reported to significantly reduce the cytotoxicity of PMMA-based bone cement compared to benzoyl peroxide (BPO). However, it is unknown whether this benefit is temporary or long-lasting, which is important to establish given that bone cement is expected to remain in situ permanently. Here, we compared the biocompatibility of PMMA-TBB and PMMA-BPO bone cements over several days. Rat femur-derived osteoblasts were seeded onto two commercially-available PMMA-BPO bone cements and experimental PMMA-TBB polymerized for one day, three days, or seven days. Significantly more cells attached to PMMA-TBB bone cement during the initial stages of culture than on both PMMA-BPO cements, regardless of the age of the materials. Proliferative activity and differentiation markers including alkaline phosphatase production, calcium deposition, and osteogenic gene expression were consistently and considerably higher in cells grown on PMMA-TBB than on PMMA-BPO, regardless of cement age. Although osteoblastic phenotypes were more favorable on older specimens for all three cement types, biocompatibility increased between three-day-old and seven-day-old PMMA-BPO specimens, and between one-day-old and three-day-old PMMA-TBB specimens. PMMA-BPO materials produced more free radicals than PMMA-TBB regardless of the age of the material. These data suggest that PMMA-TBB maintains superior biocompatibility over PMMA-BPO bone cements over prolonged periods of at least seven days post-polymerization. This superior biocompatibility can be ascribed to both low baseline cytotoxicity and a further rapid reduction in cytotoxicity, representing a new biological advantage of PMMA-TBB as a novel bone cement material.

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“…The world population is aging, and this fact will have a large impact on healthcare systems [1]. As a result, during the last decade, we have seen a rise in the number of individuals suffering from major neurocognitive disorders, such as dementia [2].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review on the Possible Relationship Between Bilingualism, Cognitive Decline, and the Onset of Dementia

Noort

Vermeire

Bosch

et al. 2019

Behavioral Sciences

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A systematic review was conducted to investigate whether bilingualism has a protective effect against cognitive decline in aging and can protect against dementia. We searched the Medline, ScienceDirect, Scopus, and ERIC databases with a cut-off date of 31 March 2019, thereby following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) protocol. Our search resulted in 34 eligible studies. Mixed results were found with respect to the protective effect of bilingualism against cognitive decline. Several studies showed a protective effect whereas other studies failed to find it. Moreover, evidence for a delay of the onset of dementia of between 4 and 5.5 years in bilingual individuals compared to monolinguals was found in several studies, but not in all. Methodological differences in the set-up of the studies seem to explain these mixed results. Lifelong bilingualism is a complex individual process, and many factors seem to influence this and need to be further investigated. This can be best achieved through large longitudinal studies with objective behavioral and neuroimaging measurements. In conclusion, although some evidence was found for a cognitive reserve-enhancing effect of lifelong bilingualism and protection against dementia, to date, no firm conclusions can be drawn.

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The Coming Gray Tide: Wanted: Health Innovations for an Increasingly Older Population

Cited by 9 publications

References 0 publications

Postablation Endometrial Carcinoma

Postablation Endometrial Carcinoma

Prolonged Post-Polymerization Biocompatibility of Polymethylmethacrylate-Tri-n-Butylborane (PMMA-TBB) Bone Cement

A Systematic Review on the Possible Relationship Between Bilingualism, Cognitive Decline, and the Onset of Dementia

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