The Common and Species-Specific Roles of Oviductal Proteins in Mammalian Fertilization and Embryo Development

Coy, Pilar; Yanagimachi, Ryuzo

doi:10.1093/biosci/biv119

Cited by 47 publications

(42 citation statements)

References 86 publications

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“…Consequently, embryo culture media have become more physiological over the past two decades, and are no longer simple salt solutions with carbohydrates (Bavister, 1995;Gardner and Lane, 1997;Lane and Gardner, 2007). However, culture media still lack several components of the complex oviduct and uterine environments, including many paracrine signalling molecules (Aviles et al, 2010;Coy and Yanagimachi, 2015;Hannan et al, 2011;Robertson et al, 2015;Salamonsen et al, 2016). Embryos themselves secrete signalling molecules into the media in vitro, and these may partially compensate for the absence of signals from the reproductive tract.…”

Section: Introductionmentioning

confidence: 99%

Combined effects of individual culture and atmospheric oxygen on preimplantation mouse embryos in vitro

Kelley

Gardner

2016

Reproductive BioMedicine Online

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Embryos are routinely cultured individually, although this can reduce blastocyst development. Culture in atmospheric (20%) oxygen is also common, despite multiple detrimental effects on embryos. Although frequently occurring together, the consequences of this combination are unknown. Mouse embryos were cultured individually or grouped, under physiological (5%) or atmospheric (20%) oxygen. Embryos were assessed by time-lapse and blastocyst cell allocation. Compared with the control group (5% oxygen group culture), 5-cell cleavage (t5) was delayed in 5% oxygen individual culture and 20% oxygen group culture (59.91 ± 0.23, 60.70 ± 0.29, 63.06 ± 0.32 h post-HCG respectively, P < 0.05). Embryos in 20% oxygen individual culture were delayed earlier (3-cell cleavage), and at t5 cleaved later than embryos in other treatments (66.01 ± 0.40 h, P < 0.001), this delay persisting to blastocyst hatching. Compared with controls, hatching rate and cells per blastocyst were reduced in 5% oxygen single culture and 20% oxygen group culture (134.1 ± 3.4, 104.5 ± 3.2, 73.4 ± 2.2 cells, P < 0.001), and were further reduced in 20% oxygen individual culture (57.0 ± 2.8 cells, P < 0.001), as was percentage inner cell mass. These data indicate combining individual culture and 20% oxygen is detrimental to embryo development.

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Section: Introductionmentioning

confidence: 99%

Combined effects of individual culture and atmospheric oxygen on preimplantation mouse embryos in vitro

Kelley

Gardner

2016

Reproductive BioMedicine Online

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“…Later, the early stages of embryo development phase (4 to 8 cells) into the uterus so that implantation to form the placenta. The whole process happens within the lumen of the oviduct and uterus, where the fluid is contained within the lumen of the oviduct and uterine (Coy and Yanagimachi, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…In mammals, the oviduct is the site where the oocyte be fertilized and zygot starts to develop. The whole process happens within the lumen of the oviduct and uterus, with variation composition of fluid inside the lumen of both the oviduct and uterine (Coy and Yanagimachi, 2015).…”

Section: Introductionmentioning

confidence: 99%

Profiling Glycoprotein of epithelial cell of oviduct at two-stages estrous cycle on Peranakan Ettawah (PE) Goat

2018

IJCTR

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Environmental condition inside the oviductal tube plays important roles for ovum viability after ovulation, sperms transport, fertilization, and early embryonic development. The composition of oviductal fluid derived from the estrogen-dependent activity of epithelial cell on its lumen is valuable in order to improve the in vitro fertilization (IVF) medium using additional specific glycoprotein of the oviduct epithelial cell secretion. The present investigation was carried out to find out whether the protein composition differs between the phases in the estrous cycle, both follicular and luteal phase and to determine composition of glycoprotein range 10-150 kDa from both phases. Electrophoresis SDS-PAGE was used to identify the oviductal glycoprotein derived from oviductal epithelial cell (OEC) in 12,5% gel concentration. Gel Documentation was used to identify varying intensity and molecular weight of each bands of the gels. Ten proteins of molecular weight in the range of 17-74 kDa were expressed between the two phases, for sample of luteal 1 and follicular 1 expressed less than 10 proteins on the gel. Only one prominent bands corresponding to 67 kDa were observed in the OEC in every samples, and heavily stained proteins of 45 kDa, 50 kDa, 74 kDa and 98 kDa were present in some samples. In conclusion, oviductal secretions derived from OEC undergo alterations in an oestrus-dependent manner and these changes were supportive for the functional role of oviducts in PE reproductive tract.

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“…The oviductal and uterine fluids, like seminal fluids, are dynamic and complex, containing a variety of compounds (reviewed in Ref. ) that influence fertilization and embryo development . Furthermore, a recent study showed that X‐ and Y‐CBS elicit different transcriptomic responses within the oviduct in the same female, implying that females can recognize X‐ and Y‐CBS even before fertilization .…”

Section: Sexual Dimorphism During Early Developmentmentioning

confidence: 99%

Developmental sexual dimorphism and the evolution of mechanisms for adjustment of sex ratios in mammals

Cameron

Edwards

Parsley

2016

Annals of the New York Academy of Sciences

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Sex allocation theory predicts biased offspring sex ratios in relation to local conditions if they would maximize parental lifetime reproductive return. In mammals, the extent of the birth sex bias is often unpredictable and inconsistent, leading some to question its evolutionary significance. For facultative adjustment of sex ratios to occur, males and females would need to be detectably different from an early developmental stage, but classic sexual dimorphism arises from hormonal influences after gonadal development. Recent advances in our understanding of early, pregonadal sexual dimorphism, however, indicate high levels of dimorphism in gene expression, caused by chromosomal rather than hormonal differences. Here, we discuss how such dimorphism would interact with and link previously hypothesized mechanisms for sex-ratio adjustment. These differences between males and females are sufficient for offspring sex both to be detectable to parents and to provide selectable cues for biasing sex ratios from the earliest stages. We suggest ways in which future research could use the advances in our understanding of sexually dimorphic developmental physiology to test the evolutionary significance of sex allocation in mammals. Such an approach would advance our understanding of sex allocation and could be applied to other taxa.

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The Common and Species-Specific Roles of Oviductal Proteins in Mammalian Fertilization and Embryo Development

Cited by 47 publications

References 86 publications

Combined effects of individual culture and atmospheric oxygen on preimplantation mouse embryos in vitro

Combined effects of individual culture and atmospheric oxygen on preimplantation mouse embryos in vitro

Profiling Glycoprotein of epithelial cell of oviduct at two-stages estrous cycle on Peranakan Ettawah (PE) Goat

Developmental sexual dimorphism and the evolution of mechanisms for adjustment of sex ratios in mammals

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