The common biological basis for common complex diseases: evidence from lipoprotein lipase gene

Abstract

The lipoprotein lipase (LPL) gene encodes a rate-limiting enzyme protein that has a key role in the hydrolysis of triglycerides. Hypertriglyceridemia, one widely prevalent syndrome of LPL deficiency and dysfunction, may be a risk factor in the development of dyslipidemia, type II diabetes (T2D), essential hypertension (EH), coronary heart disease (CHD) and Alzheimer's disease (AD). Findings from earlier studies indicate that LPL may have a role in the pathology of these diseases and therefore is a common or shared biological basis for these common complex diseases. To examine this hypothesis, we reviewed articles on the molecular structure, expression and function of the LPL gene, and its potential role in the etiology of diseases. Evidence from these studies indicate that LPL dysfunction is involved in dyslipidemia, T2D, EH, CHD and AD; and support the hypothesis that there is a common or shared biological basis for these common complex diseases.

Small bowel feeding and risk of pneumonia in adult critically ill patients: a systematic review and meta-analysis of randomized trials

“…We did not identify any eligible abstracts. We translated one article that was published in Chinese [28]. Agreement on article inclusion after full-text assessment was excellent (kappa 1.0).…”

“…In one of these trials, not all patients were admitted to the ICU but due to inclusion of severe pancreatitis patients with a mortality rate of 25% we decided to include it [32]. Nine trials investigated the use of jejunal feeding tubes [10,20,26,28,30-32,35,36] and six the use of duodenal feeding tubes [21,23-25,33,34], whereas the rest did not specify the location of the feeding tube in the small intestine [22,27,29,37]. VAP preventive strategies were not described consistently in the included studies.…”

“…Six RCTs [10,20,28,31,33,34] with 546 patients reported GI bleeding as an outcome; there was no statistically significant difference between both groups in the risk of GI bleeding (RR = 0.89; 95% CI = 0.56 to 1.42; P = 0.64; I 2 = 0%; Figure 9). …”

Оценка Эффективности Гиполипидемической Терапии Розувастатином У Больных Ишемической Болезнью Сердца В Зависимости От Генотипов Липопротеинлипазы

“…Ãåíû, âîâëå÷åííûå â ðåãóëÿöèþ ëèïèäíîãî îáìåíà (ËÎ), ðàññìàòðèâàþòñÿ êàê çíà÷èìûå ãåíåòè-÷åñêèå ôàêòîðû ðèñêà ÈÁÑ [7,11]. Ñðåäè âîçìîaeíûõ ãåíîâ-êàíäèäàòîâ ïîäâåðaeåííîñòè ÈÁÑ âûäåëÿþò ãåí ëèïîïðîòåèíëèïàçû (LPL ) -ôåðìåíò, îáåñïå÷èâàþ-ùèé ãèäðîëèç òðèãëèöåðèäîâ (ÒÃ) è ïðåâðàùåíèå õî-ëåñòåðèíà ëèïîïðîòåèäîâ î÷åíü íèçêîé ïëîòíîñòè (ÕÑ ËÎÍÏ) â õîëåñòåðèí ëèïîïðîòåèäîâ íèçêîé ïëîò-íîñòè (ÕÑ ËÍÏ) [4,5]. Ïîëèìîðôèçìû ãåíà LPL îïðå-äåëÿþò ôóíêöèîíàëüíóþ àêòèâíîñòü ôåðìåíòà è, òà-êèì îáðàçîì, ìîãóò âíîñèòü âêëàä â ïðåäðàñïîëîaeåí-íîñòü íîñèòåëåé ê ãèïåðëèïèäåìèè (ÃËÏ).…”

The expanded human disease network combining protein–protein interaction information

“…A common biological basis for some complex diseases has been reported earlier. 27 By calculating the distribution of the number of genes associated with a disorder, s, we found that most diseases have a few disease genes ( Figure 2a, the average of s was 4.75). However, the top 10 diseases related to cancer, and metabolic, neurological, psychogenic, immune and cardiovascular diseases, have dozens of disease genes.…”