Background: This study aims to reveal the relationship among empathic tendencies, life satisfaction and professional self-esteem of the Turkish military students of the school of medicine, nursing and health vocational school. Besides, the study sought to determine whether there was a mediating role of professional self-esteem between the empathetic tendency and life satisfaction of the students receiving health education.Methods: The study is arranged in accordance with the relational screening model. 870 Turkish military health students participated in the study with a survey participation rate of 95.3%. To analyze the hypothesized path model, data were analyzed using SPSS 23 and AMOS 24 programs. Results: 61.3% of participants were male and 38.7% were female. Of the 870 participants, 439 were medicals, 323 were nurses and 108 were vocational school students studying at a military medical academy. Model data fit index values were found to be within acceptable limits.Conclusions: The empathic tendency, life satisfaction and professional self-esteem levels in students receiving health education are high. There is a positive and significant relationship between the variables examined. It was found that professional self-esteem has a partial mediating role in the relationship between empathic tendency and life satisfaction.