The comparative analysis of gastrointestinal toxicity of azithromycin and 3′-decladinosyl azithromycin on zebrafish larvae

Zhang, Miaoqing; Gui-zhi, WU; Zhang, Jingpu; Hu, Chang‐Qin

doi:10.1016/j.taap.2023.116529

Cited by 5 publications

(3 citation statements)

References 51 publications

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“…Despite its clinical effectiveness, azithromycin is not without its drawbacks, as vomiting and diarrhea have been identified as primary adverse effects associated with its administration [5]. In the context of adverse reactions, this report presents a distinctive case -an inaugural instance of a purpuric-type drug eruption associated with azithromycin administration.…”

Section: Introductionmentioning

confidence: 91%

Purpuric Type Drug Eruption Caused by Azithromycin: A Case Report and Literature Review

Saito-Sasaki,

Sawada

2024

Cureus

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Azithromycin, an azolide antibiotic with structural and functional similarities to macrolides, possesses distinct features such as its effects persisting for seven days, an extended half-life by administering it once daily for three days, and strong antimicrobial activity. Notably, vomiting and diarrhea are recognized as the primary adverse events related to azithromycin.In this particular case, we present a unique case describing a purpuric-type drug eruption associated with azithromycin, which represents an uncommon cutaneous manifestation. A 64-year-old female developed a purpuric eruption on her trunk and lower extremities seven days after receiving daily intravenous azithromycin for upper bronchitis. A previous occurrence of punctate purpuric eruption following azithromycin administration was documented in her medical history. The diagnosis of azithromycininduced skin eruption was confirmed based on the clinical progression and the recurrence of the eruption upon re-administration of the drug. In response to this diagnosis, the patient underwent treatment involving the discontinuation of azithromycin and the application of topical betamethasone butyrate propionate ointment. Remarkably, her eruption significantly improved within two weeks, although residual pigmentation persisted post-treatment. Additionally, we offer a comprehensive review of the literature, examining cases of drug eruptions related to azithromycin.

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Section: Introductionmentioning

confidence: 91%

Purpuric Type Drug Eruption Caused by Azithromycin: A Case Report and Literature Review

Saito-Sasaki,

Sawada

2024

Cureus

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“…With the development of in silico tools, machine learningbased models have been applied for prediction of PFAS toxicity, 32,33 and structure−toxicity relationships have been employed to predict toxicity in silico. 34 These tools and their combination enabled the prediction of the interaction energies or activities between unknown PFASs and certain receptors like androgen receptor (AR) 35 based on limited experimental data, which is valuable for prioritizing potential health risk of PFASs.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Although 150 PFASs efficacy for multiple receptors were tested in this experiment, evaluation of PFASs for their toxicity is still a challenge since thousands of PFASs without toxicity information were identified in real sample over the past years. With the development of in silico tools, machine learning-based models have been applied for prediction of PFAS toxicity, , and structure–toxicity relationships have been employed to predict toxicity in silico . These tools and their combination enabled the prediction of the interaction energies or activities between unknown PFASs and certain receptors like androgen receptor (AR) based on limited experimental data, which is valuable for prioritizing potential health risk of PFASs.…”

Section: Introductionmentioning

confidence: 99%

Suspect, Nontarget Screening, and Toxicity Prediction of Per- and Polyfluoroalkyl Substances in the Landfill Leachate

Feng,

Lin,

et al. 2024

Environ. Sci. Technol.

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Landfills are the final stage of urban wastes containing perfluoroalkyl and polyfluoroalkyl substances (PFASs). PFASs in the landfill leachate may contaminate the surrounding groundwater. As major environmental pollutants, emerging PFASs have raised global concern. Besides the widely reported legacy PFASs, the distribution and potential toxic effects of numerous emerging PFASs remain unclear, and unknown PFASs still need discovery and characterization. This study proposed a comprehensive method for PFAS screening in leachate samples using suspect and nontarget analysis. A total of 48 PFASs from 10 classes were identified; nine novel PFASs including eight chloroperfluoropolyether carboxylates (Cl-PFPECAs) and bistriflimide (HNTf2) were reported for the first time in the leachate, where Cl-PFPECA-3,1 and Cl-PFPECA-2,2 were first reported in environmental media. Optimized molecular docking models were established for prioritizing the PFASs with potential activity against peroxisome proliferator-activated receptor α and estrogen receptor α. Our results indicated that several emerging PFASs of N-methyl perfluoroalkyl sulfonamido acetic acids (N-MeFASAAs), n:3 fluorotelomer carboxylic acid (n:3 FTCA), and n:2 fluorotelomer sulfonate (n:2 FTSA) have potential health risks that cannot be ignored.

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Azithromycin induces neurotoxicity in zebrafish by interfering with the VEGF/Notch signaling pathway

Chen,

Song,

et al. 2023

Science of The Total Environment

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The comparative analysis of gastrointestinal toxicity of azithromycin and 3′-decladinosyl azithromycin on zebrafish larvae

Cited by 5 publications

References 51 publications

Purpuric Type Drug Eruption Caused by Azithromycin: A Case Report and Literature Review

Purpuric Type Drug Eruption Caused by Azithromycin: A Case Report and Literature Review

Suspect, Nontarget Screening, and Toxicity Prediction of Per- and Polyfluoroalkyl Substances in the Landfill Leachate

Azithromycin induces neurotoxicity in zebrafish by interfering with the VEGF/Notch signaling pathway

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