The Comparative Effects of Dexamethasone, Nanocurcumin, and Coenzyme Q10 Against Lumbar Laminectomy–Induced Epidural Fibrosis in a Rat Model

Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion

“…25,26 Decreasing the oxidative stress has been proved to inhibit the epidural fibrosis and adhesion formation. 27,28 There are various antiadhesion barriers with the ability to regulate oxidative stress. 24 Wang et al 24 developed a multifunctional supramolecular hydrogel with antioxidant properties for epidural adhesion prevention.…”

“…An accumulation of reactive oxygen species (ROS) after tissue injury contributes to vascular dysfunction and remodeling through oxidative damage. The oxidative damage impaired endothelium-dependent vasodilatation and endothelial cell growth, causing apoptosis, stimulating endothelial cell migration, and activating adhesion molecules, finally leading to tissue adhesion and scar tissue formation. , Decreasing the oxidative stress has been proved to inhibit the epidural fibrosis and adhesion formation. , There are various antiadhesion barriers with the ability to regulate oxidative stress . Wang et al developed a multifunctional supramolecular hydrogel with antioxidant properties for epidural adhesion prevention.…”