The Comparative Effects of Equimolar Sevoflurane and Isoflurane in Isolated Hearts

Graf, Bernhard M.; Vicenzi, Martin N.; Bošnjak, Željko J.; Stowe, David F.

doi:10.1213/00000539-199511000-00023

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…This indi-cates that the negative inotropic effect of sevoflurane is less than that of halothane, enflurane, or isoflurane. These findings are in contrast to results of in vitro experimental studies (10,15,17,29,38) that reported that the myocardial depressant effect of sevoflurane is similar or even slightly greater than that of isoflurane. Yet, in the isolated working rat heart (43) and in isolated canine ventricular muscle strips (18), sevoflurane depresses myocardial function less than does isoflurane.…”

Section: Discussioncontrasting

confidence: 99%

Effects of sevoflurane on the contractility of ferret ventricular myocardium

Bartunek

Housmans

2000

Journal of Applied Physiology

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Isotonic and isometric variables of contractility and relaxation of isolated ferret right ventricular papillary muscles were measured before and during exposure to incremental concentrations of sevoflurane (0-4.9% vol/vol) (30 degrees C) (n = 9). In a second group of muscles (n = 8), effects of sevoflurane were compared with those of low [Ca(2+)](o) (0.45-2.25 mM in steps of 0.45 mM). Sevoflurane caused a reversible concentration-dependent decrease in contractility (ED(50) of developed force 4.6+/-0.9% vol/vol). When compared with twitches of equal amplitude in low extracellular Ca(2+) concentration, sevoflurane accelerated both isometric and isotonic relaxation. The myocardial depressant effect of sevoflurane is less than that of isoflurane and results mainly from a decrease of intracellular Ca(2+) availability. The abbreviated isometric relaxation likely reflects a decrease in Ca(2+) sensitivity and the faster isotonic relaxation may reflect a mild stimulation of Ca(2+) uptake by the sarcoplasmic reticulum.

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Section: Discussioncontrasting

confidence: 99%

Effects of sevoflurane on the contractility of ferret ventricular myocardium

Bartunek

Housmans

2000

Journal of Applied Physiology

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“…5 6 Recently, an in vitro study compared the effects of equimolar concentrations of sevoflurane and isoflurane on isolated spontaneous beating guinea pig hearts. 9 Although this study showed that sevoflurane and isoflurane produced equivalent chronotropic and coronary vasodilatory effects, it should be noted that heart rate was not maintained constant, and left ventricular pressure is not considered a good index of the inotropic status of the myocardium.…”

Section: Discussionmentioning

confidence: 71%

Comparison of the effects of sevoflurane, isoflurane and halothane on rat myocardium

Hanouz

Vivien

Gueugniaud

et al. 1998

British Journal of Anaesthesia

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The effects of sevoflurane on myocardial contraction and relaxation are poorly understood. Therefore, we studied the effects of equianaesthetic concentrations (0.5, 1, 1.5, 2 and 2.5 MAC) of sevoflurane, isoflurane and halothane on inotropic and lusitropic (myocardial relaxation) variables, and post-rest potentiation in rat left ventricular papillary muscles in vitro. Sevoflurane and isoflurane caused comparable concentration-dependent negative inotropic effects which were significantly lower than those induced by halothane (P < 0.05). Sevoflurane and isoflurane did not modify lusitropic variables under low or high load, whereas halothane showed a negative lusitropic effect at high concentrations. Halothane suppressed post-rest potentiation, whereas isoflurane and sevoflurane did not. Post-rest recovery was unaffected by halothane, isoflurane or sevoflurane at any concentration. Thus in rat myocardium, sevoflurane and isoflurane caused comparable negative inotropic effects, had no significant lusitropic effects and did not alter post-rest potentiation, suggesting that they did not significantly modify the functions of the sarcoplasmic reticulum.

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“…Graf et al [12] also reported that sevoflurane and isoflurane produced equivalent negative inotropic, chronotropic, metabolic, and vasodilatory effects in a concentration-dependent manner in isolated hearts. In the canine model of multivessel coronary artery obstruction, sevoflurane did not decrease myocardial blood flow derived from coronary collateral vessels [13].…”

Section: Introductionmentioning

confidence: 95%