The COMPARATIVE EFFECTS OF METACORTANDRACIN, 9-Α-Flu0r0hydr0c0rtis0ne AND HYDROCORTISONE UPON ACTH SECRETION IN MAN*

Kupperman, Herbert S.; Blatt, Meyer H. G.; Vesell, Morton; Gagliani, John; Weisbader, Hans; Vosburgh, Lee F.

doi:10.1210/jcem-15-8-911

Cited by 23 publications

(4 citation statements)

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“…Cortisone administered orally also appears to be about two-thirds as effective as hydrocortisone in suppression of the adrenal (22). In addition, studies on the relative potency of cortisone and hydrocortisone in the rat, through the use of such indices as thymic involution, liver glycogen deposition, and the muscle work test, have shown that cortisone is only about two-thirds as active as hydrocortisone (23).…”

Section: Discussionmentioning

confidence: 99%

The Physiological Disposition and Metabolic Fate of Cortisone in Man

Peterson¹,

Pierce²,

Wyngaarden³

et al. 1957

J. Clin. Invest.

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In an earlier paper we described studies on the physiological disposition and metabolic fate of hydrocortisone in man (1). This paper describes similar studies on cortisone. Although contributing very little to the body pool of adrenal cortical steroids, cortisone has been used extensively as a therapeutic agent, and it was therefore of interest to compare its metabolism with that of hydrocortisone. Large doses of cortisone and hydrocortisone were administered intravenously and rates of disappearance from the plasma determined in normal subjects and in patients with liver disease, myxedema, thyrotoxicosis, and rheumatoid arthritis. Trace quantities of cortisone-4-C" and hydrocortisone-4-C" were employed in certain studies. From these studies, information was obtained regarding rate of metabolic transformation, rate of absorption, rates and routes of excretion of cortisone and its metabolites, and, to some extent, the identity and amount of these metabolites. Information was also obtained on the in vivo conversion of cortisone to hydrocortisone. MATERIALS AND METHODSAdministration of steroid. The steroids were dissolved in 25 ml. ethanol and added to 500 ml. of sterile five per cent dextrose in water. This solution was administered intravenously over a period of 10 to 20 minutes. For oral or intramuscular administration the steroids were suspended in saline. Cortisone-4-C" was administered intravenously in trace quantities in a small volume of five per cent ethanol in water over a period of 3 to 5 minutes, or mixed with carrier cortisone and given in 500 ml. of three per cent ethanol in five per cent dextrose in sterile distilled water. Following the administration of the steroids, blood samples were drawn in heparinized syringes every 20 or 30 minutes for 2 hours-or more.Urine samples were collected and preserved by freezing.Methods of assay. The extraction procedures for the steroids in plasma and urine were the same as those de-

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Section: Discussionmentioning

confidence: 99%

The Physiological Disposition and Metabolic Fate of Cortisone in Man

Peterson¹,

Pierce²,

Wyngaarden³

et al. 1957

J. Clin. Invest.

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“…This is in contrast with 9-a-fluorohydrocortisone, which although an even more active inhibitor of corticotrophin, induces fluid retention and oedema so readily that its use in the treatment of adrenal virilism is impracticable (Kupperman et al, 1955).…”

Section: Discussionmentioning

confidence: 95%

“…They are much more active than the parent steroids but have little or no effect on the blood electrolytes. Kupperman et al (1955) compared the effect of oral cortisone and prednisone in the treatment of adrenal virilism and concluded that prednisone is the steroid of choice, since they found that it was three to four times more active than cortisone and did not induce sodium retention.…”

mentioning

confidence: 99%

Adrenal Virilism Treated with Steroids

Spence¹,

Jenkins²,

Robinson³

1956

BMJ

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“…We studied fludrocortisone acetate in patients with the adrenogenital syndrome, comparing its adrenocorticotropic‐inhibiting properties to those of other corticoid steroids. Not only was there effective inhibition of endogenous corticotropin secretion when fludrocortisone was used in doses of 2 to 3 mg. per day, but there was also the undesirable effect of profound sodium retention with edema (8). This latter phenomenon led us to the evaluation of the use of this drug as an adjunct to hydrocortisone in the complete oral replacement therapy of patients with primary or secondary hypofunction of the adrenal cortex (9, 10).…”

Section: Evolution Of Mineralocorticoid Replacement Maintenance Theramentioning

confidence: 99%