The comparative effects of povidone-iodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT—results of a randomized multicentre study

Vokurka, Samuel; Bystřická, Eva; Koza, Vladimír; Scudlová, Jana; Pavlicová, Vladislava; Valentová, Dana; Bocková, Jana; Misaniová, Lubica

doi:10.1007/s00520-005-0792-9

Cited by 50 publications

(42 citation statements)

References 12 publications

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“…It was found that the subjects receiving this special oral hygiene regimen had a significantly lower incidence of OM as compared to a control group which consisted of basic toothbrushing on their own (n=20 in each group) [85]. On the other hand, a multicenter RCT with 132 HSCT patients found no difference between mouth rinsing with povidone-iodine or saline in OM, fever of unknown origin, or other infections [82]. No guideline was possible due to insufficient and conflicting evidence.…”

Section: Povidone-iodinementioning

confidence: 99%

Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients

Saunders

Epstein²,

Sharon

et al. 2013

Support Care Cancer

148

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Purpose The aim of this project was to develop clinical practice guidelines on the use of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the prevention and management of oral mucositis (OM) in cancer patients. Methods A systematic review of the available literature was conducted. The body of evidence for the use of each agent, in each setting, was assigned a level of evidence. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, or no guideline possible. and doxepin rinse in head and neck radiation therapy (H&N RT) patients. Recommendations were developed against the use of topical antimicrobial agents for the prevention of mucositis. These included recommendations against the use of iseganan for mucositis prevention in HSCT and H&N RT and against the use of antimicrobial lozenges (polymyxintobramycin-amphotericin B lozenges/paste and bacitracinclotrimazole-gentamicin lozenges) for mucositis prevention in H&N RT. Recommendations were developed against the use of the mucosal coating agent sucralfate for the prevention or treatment of chemotherapy-induced or radiation-induced OM. No guidelines were possible for any other agent due to insufficient and/or conflicting evidence. Conclusion Additional well-designed research is needed on prevention and management approaches for OM.

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Section: Povidone-iodinementioning

confidence: 99%

Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients

Saunders

Epstein²,

Sharon

et al. 2013

Support Care Cancer

148

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“…A number of publications focused on oral antiseptics but their conclusions are equivocal. For example Vokurka et al 5 found no difference between the use of iodide preparations as oral antiseptics and saline. The product, Listerine (Pfizer) we used is an antiseptic agent containing essential oils (thymol, eucalyptol, menthol, methyl salicylate) and alcohol.…”

Section: Discussionmentioning

confidence: 99%

Salivary Neutrophils Level as an Indicator of Bone Marrow Engraftment

Pink¹,

Vondráková²,

Tvrdý³

et al. 2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Nine studies [4,25,26,32,39,44,63,66,69] were located that examined the effects of normal saline mouthwash on prevention of OM across a variety of treatment populations. Levels of evidence varied and results were conflicting.…”

Section: Normal Saline Mouthwashmentioning

confidence: 99%

Systematic review of basic oral care for the management of oral mucositis in cancer patients

McGuire

Fulton²,

Park

et al. 2013

Support Care Cancer

219

151

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Purpose The purpose of this project was to evaluate research in basic oral care interventions to update evidence-based practice guidelines for preventing and treating oral mucositis (OM) in cancer patients undergoing radio-or chemotherapy. Methods A systematic review of available literature was conducted by the Basic Oral Care Section of the Mucositis Study Group of MASCC/ISOO. Seven interventions-oral care protocols, dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine, and calcium phosphate-were evaluated using the Hadorn (J Clin Epidemiol 49: [749][750][751][752][753][754] 1996) criteria to determine level of evidence, followed by a guideline determination of one of the following: recommendation, suggestion, or no guideline possible, using Somerfield's (Classic Pap Cur Comments 4:881-886, 2000) schema.Results Fifty-two published papers were examined by treatment population (radiotherapy, chemotherapy, and hematopoietic stem cell transplant) and by whether the intervention aimed to prevent or treat OM. The resulting practice suggestions included using oral care protocols for preventing OM across all treatment modalities and age groups and not using chlorhexidine mouthwash for preventing OM in adults with head and neck cancer undergoing radiotherapy. Considering inadequate and/or conflicting evidence, no guidelines for prevention or treatment of OM were possible for the interventions of dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine in patients receiving chemotherapy or hematopoietic stem cell transplant, or calcium phosphate. Conclusions The evidence for basic oral care interventions supports the use of oral care protocols in patient populations receiving radiation and/or chemotherapy and does not support chlorhexidine for prevention of mucositis in head and neck cancer patients receiving radiotherapy. Additional welldesigned research is needed for other interventions to improve the amount and quality of evidence guiding future clinical care.

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The comparative effects of povidone-iodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT—results of a randomized multicentre study

Cited by 50 publications

References 12 publications

Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients

Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients

Salivary Neutrophils Level as an Indicator of Bone Marrow Engraftment

Systematic review of basic oral care for the management of oral mucositis in cancer patients

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