The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APCMin/+ mice

Wang, Ruiqi; Wang, Yan; Gao, Zu–Hua; Qu, Xian‐Jun

doi:10.5582/ddt.8.25

Cited by 33 publications

(25 citation statements)

References 25 publications

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“…In this regard, the Apc Min/C mouse model is one of the most studied models of intestinal tumorigenesis in which tumor growth is suppressed by different anticancer agents. 22,23 In the present study we used fasting as a pre-conditioning method to protect against the side-effects of irinotecan. Previously, we reported that 3-days of fasting increases stress-resistance, including upregulation of the Nrf2 pathway, which is involved in the protection against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice

et al. 2015

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Irinotecan is a widely used topoisomerase-I-inhibitor with a very narrow therapeutic window because of its severe toxicity. In the current study we have examined the effects of fasting prior to irinotecan treatment on toxicity and anti-tumor activity. FabplCre;Apc(15lox/+) mice, which spontaneously develop intestinal tumors, of 27 weeks of age were randomized into 3-day fasted and ad libitum fed groups, followed by treatment with a flat-fixed high dose of irinotecan or vehicle. Side-effects were recorded until 11 days after the start of the experiment. Tumor size, and markers for cell-cycle activity, proliferation, angiogenesis, and senescence were measured. Fasted mice were protected against the side-effects of irinotecan treatment. Ad libitum fed mice developed visible signs of discomfort including weight loss, lower activity, ruffled coat, hunched-back posture, diarrhea, and leukopenia. Irinotecan reduced tumor size in fasted and ad libitum fed groups similarly compared to untreated controls (2.4 ± 0.67 mm and 2.4 ± 0.82 mm versus 3.0 ± 1.05 mm and 2.8 ± 1.08 mm respectively, P < 0.001). Immunohistochemical analysis showed reduced proliferation, a reduced number of vascular endothelial cells, and increased levels of senescence in tumors of both irinotecan treated groups. In conclusion, 3 days of fasting protects against the toxic side-effects of irinotecan in a clinically relevant mouse model of spontaneously developing colorectal cancer without affecting its anti-tumor activity. These results support fasting as a powerful way to improve treatment of colorectal carcinoma patients.

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Section: Discussionmentioning

confidence: 99%

Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice

et al. 2015

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“…It has been widely considered that excessive cell proliferation and insufficient apoptosis are associated with tumorigenesis (Rigby et al 2007;Wang et al 2014). In Apc min/+ mouse model, different polyp sizes represent different stages of tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc Min/+ mouse model

Zhang

Wang

et al. 2015

J Cancer Res Clin Oncol

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“…These effects of AKBA were associated its proapoptotic effect against carcinoma. Western blotting and immunohistochemical evaluation indicated that underlying pathway included modulation of the Wnt/β-catenin and NF-κB/COX-2 pathways in adenomatous polyps (Wang et al, 2014).…”

Section: Gastrointestinal Cancersmentioning

confidence: 99%

Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata

Khan

Ali

Parveen

et al. 2016

Journal of Ethnopharmacology

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The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APCMin/+ mice

Cited by 33 publications

References 25 publications

Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice

Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice

Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc Min/+ mouse model

Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata

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