The comparative synthesis of ¹⁸F‐fluorophenylalanines by electrophilic substitution with ¹⁸F‐F₂ and ¹⁸F‐AcOF

Abstract

SUMMARYFluorination with 18F-F2 and 18F-AcOF were compared for the synthesis of 18F-fluorophenylalanines. L-phenylalanine in CF,COOH trapped 18F-AcOF more effectively than 18F-F2. The main product was ortho-18F-fluorophenylalanine when 18F-AcOF was used as a reagent. Lower radiochemical yield of 18F-fluorophenylalanines and si nificant formation of by-product were observed in the case o f feF-F,.

Endogenous compounds labeled with radionuclides of short half‐life—some perspectives

“…The analog tracers [2‐ 18 F]fluoro‐ l ‐phenylalanine and [2‐ 18 F]fluoro‐ l ‐tyrosine have been used as radiotracers for amino acid transport; another example is O ‐([2‐ 18 F]fluoroethyl)‐ l ‐tyrosine ([ 18 F]FET) for tumor imaging . [Methyl‐ 11 C]‐ l ‐methionine has been used for measuring amino acid transport across the placenta and also for brain tumor imaging.…”