The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms

Qiu, Wenhui; Liu, Shuai; Chen, Honghong; Luo, Shusheng; Xiong, Ying; Wang, Xuejing; Xu, Bentuo; Chen, Kewei; Wang, Kejian

doi:10.1016/j.jhazmat.2020.124303

Cited by 89 publications

(30 citation statements)

References 65 publications

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“…At 120 dpf, the liver, brain, and gonads of the same sex were sampled to analyze the expression levels of genes related to the HPGL axis. All primers of target genes were based on previous studies (Qian et al, 2020;Qiu et al, 2021) and listed in Table S1. The housekeeping gene β-actin was used as an internal control.…”

Section: Gene Expression Analysismentioning

confidence: 99%

WITHDRAWN: Exposure to Difenoconazole Induces Reproductive Toxicity of Zebrafish by Interfering Reproductive Behavior

Liu¹,

Zhou²,

Liu³

et al. 2022

Preprint

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Difenoconazole (DCZ) is a widely used triazole fungicide and negatively affects aquatic organisms and human health. However, data on the reproductive toxicity of DCZ are lacking. In this study, we used zebrafish (from 2–4 h postfertilization (hpf) to adulthood) as a model to evaluate whether DCZ at environmentally relevant concentrations (0.1, 1.0, and 10.0 µg/L) induce reproductive toxicity. Following exposure to DCZ, egg production and fertilization rate were reduced at 1.0 and 10.0 µg/L. A significant decrease in the proportion of mature gametes (late vitellogenic oocytes and spermatozoa) was also observed at 10.0 µg/L. The concentrations of 17β-Estradiol (E2), testosterone (T), and vitellogenin (VTG) were disrupted in females and males at 1.0 and 10.0 µg/L. Exposure to 10.0 µg/L DCZ significantly inhibited the contact time between female fish and male fish, and it was mainly achieved by affecting male fish. The transcription of genes involved in the hypothalamus-pituitary-gonad-liver (HPGL) axis was significantly changed after treatment with DCZ. Overall, these data showed that the endocrine disrupting effect of DCZ on the zebrafish HPGL axis inhibited the formation of gametes and disrupted reproductive behavior, thereby reducing fertility.

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Section: Gene Expression Analysismentioning

confidence: 99%

WITHDRAWN: Exposure to Difenoconazole Induces Reproductive Toxicity of Zebrafish by Interfering Reproductive Behavior

Liu¹,

Zhou²,

Liu³

et al. 2022

Preprint

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“…Contamination of aquatic systems by multiple EEs is frequently detected [ 19 , 20 ], and it has been demonstrated that in such conditions the reproductive disturbance of aquatic fauna can occur even at individual ineffective concentrations [ 25 ]. The environmental risks posed by these compounds are also due to their chemical recalcitrance that leads to a long time of persistence in aquatic and terrestrial ecosystems [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Innovative Materials from Biowaste Recycling for the Removal of Environmental Estrogens from Water and Soil

Loffredo

2022

Materials

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New technologies have been developed around the world to tackle current emergencies such as biowaste recycling, renewable energy production and reduction of environmental pollution. The thermochemical and biological conversions of waste biomass for bioenergy production release solid coproducts and byproducts, namely biochar (BC), hydrochar (HC) and digestate (DG), which can have important environmental and agricultural applications. Due to their physicochemical properties, these carbon-rich materials can behave as biosorbents of contaminants and be used for both wastewater treatment and soil remediation, representing a valid alternative to more expensive products and sophisticated strategies. The alkylphenols bisphenol A, octylphenol and nonylphenol possess estrogenic activity comparable to that of the human steroid hormones estrone, 17β-estradiol (and synthetic analog 17α-ethinyl estradiol) and estriol. Their ubiquitous presence in ecosystems poses a serious threat to wildlife and humans. Conventional wastewater treatment plants often fail to remove environmental estrogens (EEs). This review aims to focus attention on the urgent need to limit the presence of EEs in the environment through a modern and sustainable approach based on the use of recycled biowaste. Materials such as BC, HC and DG, the last being examined here for the first time as a biosorbent, appear appropriate for the removal of EEs both for their negligible cost and continuously improving performance and because their production contributes to solving other emergencies, such as virtuous management of organic waste, carbon sequestration, bioenergy production and implementation of the circular economy. Characterization of biosorbents, qualitative and quantitative aspects of the adsorption/desorption process and data modeling are examined.

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“…As such, this can induce abnormal changes within cells, altered gene expression, and specifically cause effects on target tissues containing ERs and ARs including the reproductive, nervous, immune, and cardiovascular systems ( Atay et al, 2020 , Yang et al, 2007 ). Indeed, it has been shown in several species that BPA and analogs bind to the ERs, inducing physiological actions similar to estrogen and can lead to embryonic deformities in Xenopus ( Arancio et al, 2018 , Iwamuro et al, 2003 , Tomohiro et al, 2003 ), zebrafish ( Huang et al, 2016 , Moreman et al, 2017 , Qui et al, 2020 ), and chick ( Crump et al, 2016 , Jessl et al, 2018 , Mentor et al, 2020 , Saito et al, 2012 , Tian et al, 2014 ). Here, we observed a variety of deformities in chick embryos at various doses of BPA analogs, which may at least in part be caused by the affinity that each of these chemicals has for the different ERs ( Saito et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development

Harnett

Moore

Chin

et al. 2021

Current Research in Toxicology

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The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms

Cited by 89 publications

References 65 publications

WITHDRAWN: Exposure to Difenoconazole Induces Reproductive Toxicity of Zebrafish by Interfering Reproductive Behavior

WITHDRAWN: Exposure to Difenoconazole Induces Reproductive Toxicity of Zebrafish by Interfering Reproductive Behavior

Recent Advances on Innovative Materials from Biowaste Recycling for the Removal of Environmental Estrogens from Water and Soil

Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development

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