The comparison of cardiovascular disease risk prediction scores and evaluation of subclinical atherosclerosis in rheumatoid arthritis: a cross-sectional study

Muhammed, Hafis; Misra, Durga Prasanna; Jain, Neeraj; Ganguly, Sujata; Pattanaik, Sarit Sekhar; Kumar, Mandhir; Anuja, Anamika Kumari; Mohindra, Namita; Kumar, Sudeep; Agarwal, Vikas

doi:10.1007/s10067-022-06349-y

Cited by 8 publications

(3 citation statements)

References 58 publications

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“…18,19 Studies from India have identified SCA in a similar proportion (14%) of patients with rheumatoid arthritis. 15 Indians per se are at a greater risk of cardiovascular disease which also has a younger age of onset than their Western counterparts. 20 The higher burden of SCA in Indian patients with SpA is a matter of concern, particularly because cardiovascular risk factor management is often sidelined in busy outpatient clinics.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Serological Associations of Subclinical Atherosclerosis in Spondyloarthropathy

Rai,

Jain,

Mohindra

et al. 2024

Indian Journal of Rheumatology

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Background: Patients with spondyloarthropathy (SpA) have a higher risk of subclinical atherosclerosis (SCA). We assessed clinical and serological determinants of SCA in Indian SpA patients. Methods: Patients with SpA (fulfilling ASAS 2010 criteria; n = 104) attending our hospital were recruited; mean carotid intima-media thickness (CIMT) was performed by carotid ultrasonography, along with clinical assessment and traditional risk factor evaluation. Microparticles were extracted from plasma and total, as well as endothelial microparticles (EMP), platelet microparticles, T lymphocyte microparticles and B lymphocyte microparticles, were analysed by flow cytometry. Serum samples were analysed for inflammatory cytokines previously implicated in atherosclerosis, namely interleukin 1β (IL-1β), IL-6, IL-17, IL-27, IL-33 and tumour necrosis factor-alpha. Thirty-eight healthy controls were used for comparison. Subgroup analyses compared parameters between SpA with SCA (i.e., with carotid plaque or more than 75th percentile of CIMT for that age and sex in the Indian population) versus those without SCA. Ethical approval and written, informed consent were obtained. Results: Despite significantly younger age, lower body mass index and higher total cholesterol in controls compared to SpA, those with SpA had higher CIMT. Traditional cardiovascular risk factors (older age, higher waist-hip ratio) and novel markers of inflammation (serum IL-1β, IL-6) were associated with SCA. While total microparticles, EMP, T lymphocyte and B lymphocyte microparticles were increased in SpA than in healthy controls, they were not associated with SCA. Conclusions: Traditional risk factors and serum inflammatory cytokines IL-1β and IL-6 are associated with higher SCA in Indian SpA patients.

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Section: Discussionmentioning

confidence: 99%

“…Carotid plaques were identified using standard definitions. 15 SCA was defined as CIMT more than the 75th percentile of CIMT for that age and sex in the Indian population 16 or the presence of carotid plaques. The risk of developing a heart attack or stroke over the next 10 years was calculated using QRISK3.…”

Section: Methodsmentioning

confidence: 99%

Clinical and Serological Associations of Subclinical Atherosclerosis in Spondyloarthropathy

Rai,

Jain,

Mohindra

et al. 2024

Indian Journal of Rheumatology

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“…Thickening of CIMT is often considered as a subclinical manifestation of atherosclerosis 30 and is strongly associated with cardiovascular morbidity 31,32 . In studies of patients with T2DM, CIMT increases by 0.034 mm per year 33 , and each 0.1 mm thickening of CIMT increases the risk of myocardial infarction by 10% 34 .…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and 1-year all-cause mortality in elderly hip fracture patients with type 2 diabetes mellitus: a propensity score matching study

Zhao

et al. 2023

Preprint

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Aim Diabetes can seriously affect the prognosis of elderly patients with hip fractures. The aim of this study was to investigate the clinical characteristics and 1-year all-cause mortality in elderly hip fracture patients with type 2 diabetes mellitus (T2DM). Methods This retrospective study involved patients aged ≥ 65 years old after hip fracture surgery from 2017 to 2019. Patients were divided into T2DM group and non-T2DM group based on whether T2DM was diagnosed at admission. Propensity score matching (PSM) was performed in a ratio of 1:1 in the two groups for further comparison. Clinical outcomes included the laboratory results, imaging results, perioperative complications and 1-year all-cause mortality. Results In this study, a total of 1296 elderly hip fracture patients were collected, including 331 cases in T2DM group and 965 cases in non-T2DM group. After PSM, a total of 312 pairs of cases were obtained, and all baseline data were comparable (P > 0.05). The levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, Brain natriuretic peptide and C-reactive protein in T2DM group were higher than those in non-T2DM group, and the levels of high-density lipoprotein cholesterol was lower in T2DM group (P < 0.05). The level of left atrial diameter, left ventricular end-diastolic diameter, ventricular septal thickness and carotid medial thickness were higher in the T2DM group (P < 0.05). The incidence of perioperative anemia (56.1% vs 47.1%), hypoproteinemia (53.8% vs 45.8%), electrolyte disturbances (43.6% vs 30.4%), perioperative heart failure (41.3% vs 27.9%), perioperative arrhythmias (30.1% vs 17.6%), and lung infections (21.8% vs 12.2%) was statistically significant in T2DM group (P < 0.05). During the 1-year follow-up period, patients with T2DM were 2 times more likely to die than those without T2DM (HR = 2.104, 95% CI 1.437, 3.080). Conclusion Elderly patients with T2DM are more likely to have multiple comorbidities, they are more likely to have dyslipidemia and cardiac structural changes, the incidence of perioperative complications after hip fracture is high. T2DM is an independent risk factor for 1-year mortality in elderly patients with hip fractures, which increases the risk of death twofold. To improve the postoperative outcomes of patients with T2DM who have undergone hip fracture surgery, effective treatment models such as multidisciplinary collaboration and individualized management should be established.

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Prevalence of cardiovascular diseases and traditional cardiovascular risk factors in patients with rheumatoid arthritis: a real-life evidence from BioSTAR nationwide registry

Duruöz,

Ataman,

Bodur

et al. 2023

Rheumatol Int

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The comparison of cardiovascular disease risk prediction scores and evaluation of subclinical atherosclerosis in rheumatoid arthritis: a cross-sectional study

Cited by 8 publications

References 58 publications

Clinical and Serological Associations of Subclinical Atherosclerosis in Spondyloarthropathy

Clinical and Serological Associations of Subclinical Atherosclerosis in Spondyloarthropathy

Clinical characteristics and 1-year all-cause mortality in elderly hip fracture patients with type 2 diabetes mellitus: a propensity score matching study

Prevalence of cardiovascular diseases and traditional cardiovascular risk factors in patients with rheumatoid arthritis: a real-life evidence from BioSTAR nationwide registry

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