BackgroundDue to the epidemiologic transition and a rise in the prevalence of non-communicable diseases different coping strategies have been studied and developed. These strategies may help the affected people to conduct a normal life style.ObjectivesThis research was conducted in Qazvin, Iran to determine the relationship between coping strategies, hardiness, and occupational life quality in Type II diabetic patients and healthy people.Patients and MethodsQuestionnaires such as Valton’s on “occupational life quality,” Billings and Moos’ examination of “Coping strategies,” and Kobasa’s investigation of “hardiness” were applied to collect the data needed for the present study. In this regard, 80 people were randomly selected from employees of offices in Qazvin, Iran.ResultsThe results of this research indicated that there is a significant relationship between problem-focused strategies, emotion-focused strategies, hardiness, and occupational life quality in people suffering from Type II diabetes and healthy people (P ≤ 0.05). These results also indicated that hardiness does not predict occupational life quality of people suffering from Type II diabetes.ConclusionsThe results of the present study give some evidence that allows us to conclude that hardiness and coping strategies affect occupational life quality for both people suffering from Type II diabetes and healthy people. Therefore, it is proposed that people strengthen their hardiness and coping strategies, in order to improve their occupational life quality.