The Comparison of Eyelash Lengthening Effect of Latanoprost Therapy in Adults and Children

Abstract

The differences in mean eyelash lengths at baseline and at the sixth month of latanoprost therapy were statistically significant in both adults and children (p=0.000). The mean of the difference of the eyelash length in children was higher than in adults but the result was not statistically significant (p=0.678).

Adverse periocular reactions to five types of prostaglandin analogs

“…The appearance frequencies of eyelid pigmentation with the use of PG analogs are reported to be 0, 2 0.8, 3 In these previous studies, [2][3][4][5][6][7][8][9][10][11][12][13][14][15] there were variations in the frequency of the administration period, method used for judging adverse reactions (by slit lamp or images), and race. Owing to differences in the administration period, the appearance frequency of eyelid pigmentation was 1.5-2.9% 4 in patients with o3 months of medication use and 0-25.9% 2,3,[5][6][7][8]15 in patients with 43 months of medication use.…”

“…Owing to differences in the administration period, the appearance frequency of eyelid pigmentation was 1.5-2.9% 4 in patients with o3 months of medication use and 0-25.9% 2,3,[5][6][7][8]15 in patients with 43 months of medication use. The appearance frequency of changes in eyelashes was 0-33.8% 4,10,12,15 in patients with o3 months of use and 0.7-77% [5][6][7][8][9][10][11]13,14 in patients with 43 months of use.…”

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Of these, changes in eyelashes, eyelid pigmentation, iris pigmentation, hypertrichosis around the eye, appearance of iritis, and deepening of the upper eyelid sulcus are thought to be characteristic adverse reactions to PG analogs. The frequency of eyelid pigmentation was reported to be between 0 and 25.9%, [2][3][4][5][6][7][8][9] and eyelash bristles are reported to occur in 0-77.0% of patients [4][5][6][7][8][9][10][11][12][13][14][15] with PG analog use. However, no study has compared the frequency of occurrence of eyelid pigmentation and eyelash bristles with the use of five types of PG analogs.…”

Latanoprost in pediatric glaucoma—pediatric exposure over a decade

“…Iris cysts, cystoid macular edema, anterior uveitis, and reactivation of herpes simplex keratitis have also been reported. [13][14][15][16][17][18][19][20] One small prospective study of latanoprost in children with glaucoma 12 suggested that this drug may work better in those with juvenile open-angle glaucoma (JOAG) than with congenital or aphakic glaucoma, but the study was limited by its small numbers and short duration. The purpose of this study was to evaluate the safety and IOP-lowering effect of latanoprost in various pediatric glaucomas over a long period of time.…”

Travoprost in children: Adverse effects and intraocular pressure response

“…Eyelash thickening and lengthening did not result in the discontinuation of the drug in the present study. 1 No children demonstrated clinically noticeable iris heterochromia; however, this is difficult to fully access without photographs. 2 Conjunctival injection resulted in drug dis- A child-month equals one month of travoprost use in two eyes of a child with glaucoma.…”