The Comparison of Helical-IMRT, Direct-IMRT and 3D Radiotherapy Modalities in Breast Radiotherapy Planning

Erdiş, Eda; Yücel, Birsen; Özyürek, Betül; Bozca, Recep

doi:10.5505/tjo.2020.2271

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“…Study findings revealed that an effective surface dose was achieved with helical IMRT independent of respiratory movement. Numerous dosimetric studies in the literature evaluated the dose distribution of helical-IMRT in the treatment of breast cancer, and the appropriateness of the dose distribution was reported [5,6,[12][13][14][15]. These studies are summarized in Table 3.…”

Section: Discussionmentioning

confidence: 99%

Helical tomotherapy experience in breast cancer adjuvant radiotherapy and acute toxicity results

İnan

Aral

Arslan

et al. 2022

Rep Pract Oncol Radiother.

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Background: This study aimed to evaluate acute toxicity and oncological outcomes of breast cancer patients who underwent adjuvant radiotherapy (RT) with tomotherapy. Materials and methods:The results of 114 patients who underwent adjuvant RT with Tomotherapy device between 17.08.10-12.06.2021 in XXX Hospital were evaluated retrospectively. The primary endpoint of the study was acute adverse events, and the secondary endpoints were overall survival (OS) and disease-free survival (DFS). Results:The results of 103 patients who met the inclusion criteria were analyzed. The median follow-up was 21 (range 1-125.8) months. Grade +3 esophagitis was not observed in any patient; no esophagitis was observed in 60 (58.3%) patients. Grade 3 dermatitis was observed in 3 (2.9%) patients. In addition, dermatitis was not observed in 47 (45.6%) patients. The relationship between chest wall volume and esophagitis development was statistically significant (p = 0.006; Z score: -2769). The median OS was 24.1 (range 1-128.5) and median disease-free survival was 21.1 (range 1-125.8) months. Five patients (4.9%) died and 9 patients (8.7%) relapsed. Local recurrence was observed in only 1 (1%) patient. There was a statistically significant correlation between OS and contralateral lung V20 dose [p < 0.001; Spearman Correlation Coefficient (SCC) -406) and heart mean dose (p < 0.001; SCC -370)]. There was a statically significant correlation between DFS and cN (p < 0.001); pN (p < 0.001); heart mean dose (p < 0.001; SCC -351); contralateral lung V5 dose (p = 0.041; SCC -213); contralateral lung V20 dose (p < 0.001; SCC -434). Conclusion:Acute toxicity results show improvement in breast cancer adjuvant radiotherapy with helical tomotherapy.

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