The comparison of immobility time in experimental rat swimming models

Calil, Caroline Morini; Marcondes, Fernanda Klein

doi:10.1016/j.lfs.2006.06.003

Cited by 21 publications

(18 citation statements)

References 41 publications

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“…With respect to muscle glycogen reserves, it was observed that due to the increase in energy requirements generated by the inducing acute exercise condition the reserves were depleted (FIGURE 1). These results corroborate with recent studies, which suggest that the intensity and duration of the stressor may modulate the utilization of energy substrates, with a special energy source, the degradation of muscle glycogen 15,[24][25] . Thus, metformin was used in this study to verify its efficiency in conditions of acute exercises, based on published reports that indicate that the biguanide promotes a significant improvement in muscle glucose metabolism [26][27][28] .…”

Section: Discussionsupporting

confidence: 92%

Hepatic and skeletal muscle glycogen content in rats treated with metformin and submitted to acute exercise by swimming

Pezolato¹,

Marques²,

Abreu³

et al. 2018

Rev Bras Educ Fís Esporte

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O objetivo deste estudo foi avaliar o comportamento das reservas glicogênicas de ratos, submetidos a uma condição de exercício agudo (50 minutos de natação na intensidade leve), após o tratamento com metformina. Quarenta ratos Wistar (180-200g) adultos foram divididos em quatro grupos (tratados ou não por quinze dias) e assim representados: Controle; Exercício agudo por natação (realizaram uma sessão de natação, sendo 50 minutos na intensidade leve); Tratado com metformina (receberam o fármaco metformina na dosagem de 1,4 mg/ml, durante o período experimental; Tratados com metformina e submetidos a condição exercício agudo por natação (receberam o fármaco metformina na dosagem de 1,4 mg/ml e realizaram uma sessão de natação, sendo 50 minutos na intensidade leve). O exercício agudo diminuiu as reservas glicogênicas, já os animais tratados com metformina, apresentaram um aumento em suas reservas glicogênicas musculares e hepáticas em relação ao grupo que realizou o exercício sem suplementação (p0,05). O tratamento com metformina promoveu melhora nas condições energéticas e menor resposta ao estresse, sugerindo ser uma importante ferramenta farmacológica para a potencialização da performance.

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Section: Discussionsupporting

confidence: 92%

Hepatic and skeletal muscle glycogen content in rats treated with metformin and submitted to acute exercise by swimming

Pezolato¹,

Marques²,

Abreu³

et al. 2018

Rev Bras Educ Fís Esporte

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“…For mice, the forced-swimming conditions used in this test resemble more closely the situation of swimming-stress (once the animal does not touches the bottom with its hind paws) and in these conditions drugs like diazepam have the ability to increase immobility time [62,63] just as it was observed in our assay. Other structurally related compounds like apigenin, upon acute treatment with relatively high doses (25 mg/kg), have induced an antidepressant-like activity (reduction in immobility time) in the forced-swimming test [64].…”

Section: Discussionmentioning

confidence: 79%

“…The meaning of immobility in swimming tests may vary in accordance with the protocol reflecting helplessness or adaptation in the forced-swimming test or in the swimming stress, respectively [62]. For mice, the forced-swimming conditions used in this test resemble more closely the situation of swimming-stress (once the animal does not touches the bottom with its hind paws) and in these conditions drugs like diazepam have the ability to increase immobility time [62,63] just as it was observed in our assay.…”

Section: Discussionmentioning

confidence: 99%

Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity

Coleta

Campos

Cotrim

et al. 2008

Behavioural Brain Research

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Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABA A receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin have been reported for their anxiolytic-like activity in different animal models of anxiety. Luteolin (3 ,4 ,5,7-tetrahydroxyflavone) is a widespread flavonoid aglycon that was reported as devoid of specific affinity for benzodiazepine receptor (BDZ-R) binding site, but its psychopharmacological activity is presently unknown. Considering (1) the close structural similarity with other active flavones, (2) the activity of some of its glycosilated derivatives and (3) the complexity of flavonoid effects in the central nervous system, luteolin was submitted to a battery of tests designed to evaluate its possible activity upon the CNS and its ability to interact with the BDZ-receptor binding sites was also analysed.Luteolin apparently has CNS activity with anxiolytic-like effects despite the low affinity for the BDZ-R shown in vitro. Our findings suggest a possible interaction with other neurotransmitter systems but we cannot rule out the possibility that luteolin's metabolites might show a higher affinity for the BDZ-R in vivo, thus eliciting the evident anxiolytic-like effects through a GABAergic mechanism.

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“…Male rats were used for this test (Padovan & Guimaraes, 2004;Calil & Marcondes, 2006). Swimming sessions were conducted by placing rats in an individual glass cylinder (35 cm × 25 cm) containing water (25° ± 1°C) 27 cm deep.…”

Section: Behavior Despair Testmentioning

confidence: 99%

Neuropharmacological activity of hydroalcoholic extract of leaves ofColocasia esculenta

Kalariya

Parmar

Sheth

2010

Pharmaceutical Biology

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The comparison of immobility time in experimental rat swimming models

Cited by 21 publications

References 41 publications

Hepatic and skeletal muscle glycogen content in rats treated with metformin and submitted to acute exercise by swimming

Hepatic and skeletal muscle glycogen content in rats treated with metformin and submitted to acute exercise by swimming

Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity

Neuropharmacological activity of hydroalcoholic extract of leaves ofColocasia esculenta

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