The Comparison of Independent Data Samples

Sachs, Lothar

doi:10.1007/978-1-4612-5246-7_6

Cited by 5 publications

(8 citation statements)

References 116 publications

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“…Via the Wilcoxon test, 17 the difference between the averages gave a p-value of 0.046, with 15 positive differences and 23 negative differences between the paired results, which represented a significant difference, albeit very close to the significance limit of 0.05. The Spearman test, 17 comparing the same paired results from the two methods, detected that there was a statistically significant correlation (p=0.0001) between the two methods, with r=0.614 (0.489-0.715).…”

Section: Resultsmentioning

confidence: 75%

“…The Spearman test, 17 comparing the same paired results from the two methods, detected that there was a statistically significant correlation (p=0.0001) between the two methods, with r=0.614 (0.489-0.715). Figure 1 shows the straight-line Passing-Bablok regression 15 and demonstrates linearity between the two methods, although significant proportional deviation is presented (p<0.01).…”

Section: Resultsmentioning

confidence: 99%

“…For the three cases that were positive in the biological test, the N2A cells presented two values of 2+ and only one of 3+. The Spearman correlation test 17 presented a strong correlation between the two methods of cell culturing, with an r coefficient of 0.797 (0.536-0.918) and a p-value of 0.0007, while the coefficients between the biological test and the two cell methods presented moderate correlation values of r=0.647 (0.273-0.851) and p=0.006 for N2A and r=0.677 (0.536-0.918) and p=0.004 for McCoy. The correlation value between the two cell culturing methods for the second analysis (i.e.…”

Section: Resultsmentioning

confidence: 99%

“…The Bland & Altman technique 2 was utilized for assessing the sampling bias, and the Passing-Bablok technique 15 for checking the linearity between the two methods. Wilcoxon 17 statistics were run to evaluate the differences between the averages for the two groups (N2A and McCoy cell systems), and the Spearman correlation coefficient 17 was determined for checking the correlation between the two methods.…”

Section: Methodsmentioning

confidence: 99%

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Estimativa de validade de um novo método de isolamento de vírus rábico

Nogueira

2004

Rev. Saúde Pública

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Section: Resultsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Estimativa de validade de um novo método de isolamento de vírus rábico

Nogueira

2004

Rev. Saúde Pública

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“…Statistical analyses were undertaken using Mystat statistical package (Macintosh). Differences between experimental groups and also within groups which required multiple comparisons were determined by Student's t-test with Bonferroniadjusted probabilities which control for the number of statistical tests (19).…”

Section: Discussionmentioning

confidence: 99%

Reverse Haemolytic Plaque Assay Study of Corticotropin‐Releasing Hormone and Arginine Vasopressin Interaction in Ovine Corticotropes

Madsen

Chan

Falconer

et al. 1991

J Neuroendocrinology

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Corticotropin-releasing hormone and arginine vasopressin are known to interact in stimulating secretion of adrenocorticotropinrelated peptides from corticotropes. However, the mechanism mediating this interaction is uncertain. Recently, evidence has been provided using a reverse haemolytic plaque assay that in rat pituitary cells, arginine vasopressin potentiates the effects of corticotropin-releasing hormone by increasing the percentage of target cells that secrete adrenocorticotropin. To determine whether a similar mechanism also operates in the sheep corticotrope, which is reportedly more sensitive to arginine vasopressin than that of the rat, a reverse haemolytic plaque assay for /%endorphin secretion was used to study the response of ovine corticotropes to stimulation by increasing doses of corticotropin-releasing hormone or arginine vasopressin (0.1 nM to 10.0 nM) alone or in combination.In the reverse haemolytic plaque assay, P-endorphin antiserum at 1 5 0 and complement at 1:lO were found to be optimal dilutions for plaque formation. A concentration-dependent response curve to corticotropin-releasing hormone was obtained with a significant increase in plaque area from basal to reach maximal levels at 1.0 nM. Arginine vasopressin also stimulated an increase in plaque area, however, plaques formed were significantly smaller than those caused by corticotropin-releasing hormone. Since in the reverse haemolytic plaque assay, plaque area is related to the amount of hormone secreted by the cell, results demonstrate that although corticotropin-releasing hormone and arginine vasopressin both stimulate b-endorphin secretion from ovine corticotropes, corticotropin-releasing hormone is a more potent secretagogue than arginine vasopressin in that it causes the formation of significantly larger plaques.The addition of arginine vasopressin to low concentrations of corticotropin-releasing hormone caused plaque areas to reach maximal levels at 0.1 nM whereas these levels were only attained at 1.0 nM when corticotropin-releasing hormone was used alone. Therefore, arginine vasopressin interacts with corticotropin-releasing hormone to increase corticotrope responses by increasing their secretory response to corticotropin-releasing hormone. These data are consistent with previous work suggesting that arginine vasopressin increases the expression of corticotropin-releasing hormone receptors on the corticotrope cell surface. However, no significant increase in the percentage of plaque-forming cells was seen with either corticotropin-releasing hormone or arginine vasopressin alone or in combination implying that there was no recruitment of previously non-secreting cells.It is now well established that secretion of proopiomelanocortin fragments, such as adrenocorticotropin (ACTH) and j-endorphin (j-EP), from corticotropes of the anterior pituitary in mammals is regulated by a number of releasing factors secreted from the hypothalamus (1). In the rat, the 41 amino-acid peptide corticotropin-releasing hormone (CRH) is cons...

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Effects of celecoxib, medroxyprogesterone, and dietary intervention on systemic syndromes in patients with advanced lung adenocarcinoma: a pilot study

Cerchietti

Navigante

Peluffo

et al. 2004

Journal of Pain and Symptom Management

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Systemic syndromes characterized by a persistent activity of circulating mediators (cytokines) are frequently present with advanced cancer. We grouped under the general heading of "Systemic Immune-Metabolic Syndrome (SIMS)" a particular variety of distressing systemic syndrome characterized by dysregulation of the psycho-neuro-immune-endocrine homeostasis, with overlapping clinical manifestations. SIMS may include cachexia, anorexia, nausea, early satiety, fatigue, tumor fever, cognitive changes and superinfection. The aim of this study was to ameliorate some of the SIMS symptoms in a homogeneous group of lung adenocarcinoma patients using a multitargeted therapy. Fifteen patients with evidence of SIMS were studied. SIMS was defined as the presence of weight loss, anorexia, fatigue performance status>/=2 and acute-phase protein response. Patients received medroxyprogesterone (MPA) (500 mg twice daily), celecoxib (200 mg twice daily), plus oral food supplementation for 6 weeks. After treatment, 13 patients either had stable weight (+/- 1%) or had gained weight. There were significant differences in improvement of body-weight-change rate, nausea, early satiety, fatigue, appetite and performance status. Patients who had any kind of lung infection showed higher levels of IL-10 compared to non-infected patients (P=0.039). Our results suggest that patients with advanced lung adenocarcinoma, treated with MPA, celecoxib and dietary intervention, might have considerable improvement in certain SIMS outcomes. This multitargeted symptomatic approach deserves further study.

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The Comparison of Independent Data Samples

Cited by 5 publications

References 116 publications

Estimativa de validade de um novo método de isolamento de vírus rábico

Estimativa de validade de um novo método de isolamento de vírus rábico

Reverse Haemolytic Plaque Assay Study of Corticotropin‐Releasing Hormone and Arginine Vasopressin Interaction in Ovine Corticotropes

Effects of celecoxib, medroxyprogesterone, and dietary intervention on systemic syndromes in patients with advanced lung adenocarcinoma: a pilot study

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