The Comparison of Infusion of Two Different Sedation Regimens with Propofol and Ketamine Combination During Plastic and Reconstructive Surgery

Abstract

We recommend the use of a 2:1 combination of propofol-ketamine, because it reduced the rescue propofol requirement and consequently produced lower cardiovascular and respiratory depression effects and also less postoperative pain.

Use of Propofol in Combination with Remifentanil for Plastic and Reconstructive Surgery

“…Low doses of ketamine can be useful for analgesia and sedation [1,2] but may also be associated with a variety of adverse effects including increased oral secretion, nausea and vomiting, hemodynamic instability, and postoperative hallucinations [3]. This may limit the use of ketamine, particularly in patients with cardiovascular, respiratory, neurological, psychological, and other diseases, which was shown in the study [1].…”

“…This may limit the use of ketamine, particularly in patients with cardiovascular, respiratory, neurological, psychological, and other diseases, which was shown in the study [1]. Considering that an increasing number of elderly patients with some of the aforementioned comorbidities are seeking aesthetic surgery, the routine use of ketamine for procedural sedation may not be appropriate in clinical settings.…”

“…For a full description of these Evidence-Based Medicine ratings, please refer to the [1]. The authors evaluated the effects of a mixture of propofol and two different concentrations of ketamine on sedation in adult patients undergoing plastic and reconstructive surgery.…”