The Comparison of Noninvasive Ventilation, High-Flow Oxygen Therapy and Conventional Oxygen Therapy for Weaning Failure in High-Risk Patients

Mungan, İbrahim; Turan, Sema

doi:10.5222/gkdad.2021.05025

Cited by 2 publications

(1 citation statement)

References 22 publications

(34 reference statements)

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“…Mungan et al conducted a prospective, observational, cohort study to determine the effects of the use of HFNC, conventional oxygen therapy, and non-invasive ventilation (NIV) on weaning failure in high-risk patients and recorded the lowest re-intubation rate along with a reduced ICU stay and hospital stay in the HFNC group. The study also reported that the total mechanical ventilation assistance duration and length of stay in the ICU and hospital differed between groups receiving NIV, HFNC, and conventional oxygen therapy, thus favoring the high-flow oxygen therapy group [21].…”

Section: Discussionmentioning

confidence: 91%

High-Flow Nasal Cannula as an Alternate Weaning Strategy: A Randomized Controlled Trial

Arora¹,

Arshad²,

Prakash³

et al. 2023

Cureus

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BackgroundExtubation failure is associated with increased morbidity and poor outcomes. This study aimed to ascertain the effectiveness of a high-flow nasal cannula (HFNC) as a weaning method compared to conventional weaning. MethodologyA total of 60 mechanically ventilated patients, aged 18-65 years, who were ventilated for 48 hours and whose underlying pathology had either resolved or was improving, were enrolled in this study. They were randomized in a 1:1 ratio to participate in the HFNC weaning method or receive conventional weaning. Patients in Group A were extubated and oxygen was provided via HFNC. Group B patients were given a spontaneous breathing trial (SBT) per the standard protocol and extubated after a successful SBT. ResultsWeaning failure was found in five patients and was higher in the conventional group (three patients in the conventional group and two patients in the HFNC group). The duration of stay of patients in intensive care units was significantly higher in the conventional group than in the HFNC group. ConclusionsHFNC is a better alternative to conventional weaning through SBT.

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Section: Discussionmentioning

confidence: 91%

High-Flow Nasal Cannula as an Alternate Weaning Strategy: A Randomized Controlled Trial

Arora¹,

Arshad²,

Prakash³

et al. 2023

Cureus

View full text Add to dashboard Cite

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Effectiveness of high-flow nasal cannula versus noninvasive ventilation and conventional oxygen therapy in patients weaned from invasive mechanical ventilation

Elghonemy,

Korraa,

Mohammed

2024

Egypt J Bronchol

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Background Reintubation after liberation from mechanical ventilation is a common adverse event observed in the intensive care unit (ICU) with significant implications for patient outcomes. Sequential oxygen therapies, including noninvasive ventilation (NIV) and high-flow nasal cannula (HFNC) in addition to the conventional oxygen therapy (COT), are commonly employed in the post-extubation setting to lessen reintubation risk, but their comparative efficacy remains controversial. Objective To compare the efficacy of NIV, HFNC, and COT as post-extubation respiratory support. Methods A prospective, randomized, clinical, parallel-group study enrolled extubated patients who were randomized and assigned to receive either NIV support or HFNC or COT. Primary outcomes included reintubation rates while secondary outcomes included post-extubation hemodynamics and arterial blood gases (ABGs), ICU length of stay, and ICU mortality. Results Sixty patients were recruited and equally randomized into the three groups (20 per group). The NIV and HFNC groups had lower reintubation rates [9/20 (45%), 12/20 (60%), respectively] compared to the COT group (15/20, 75%), yet with insignificant difference between the three groups (p > 0.05). The relative risk (RR) and 95% confidence interval (CI) of reintubation were insignificantly lower in the NIV group [RR, 0.600; 95% CI 0.347–1.036, p = 0.067], and to a lesser extent in the HFNC group [RR, 0.800; 95% CI 0.516–1.240, p = 0.318] compared to the COT group, while RR between NIV and HFNC groups was 0.750; 95% CI 0.411–1.370; p = 0.350. The NIV and HFNC groups had similar, significantly shorter ICU length of stay compared to the COT group (p < 0.001). ICU mortality was lowest in the NIV group (8/20, 40%), followed by the HFNC (13/20, 65%) and highest in the COT group (15/20, 75%) with significant difference between the NIV and COT groups [RR, 0.53; 95% CI 0.29–0.96, p = 0.037]. Conclusion The study findings suggest comparable efficacy of NIV, HFNC, and COT devices in preventing reintubation within 48 h post-extubation, and NIV displayed some advantages over HFNC and COT in terms of lower reintubation and mortality rates. Trial registration ClinicalTrials.gov, NCT06593509. Registered 17 August 2024—retrospectively registered.

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The Comparison of Noninvasive Ventilation, High-Flow Oxygen Therapy and Conventional Oxygen Therapy for Weaning Failure in High-Risk Patients

Cited by 2 publications

References 22 publications

High-Flow Nasal Cannula as an Alternate Weaning Strategy: A Randomized Controlled Trial

High-Flow Nasal Cannula as an Alternate Weaning Strategy: A Randomized Controlled Trial

Effectiveness of high-flow nasal cannula versus noninvasive ventilation and conventional oxygen therapy in patients weaned from invasive mechanical ventilation

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