BACKGROUND Nephrolithiasis is a common urological disorder. PCNL is indicated for renal calculi > 2 cm in size. We present a prospective study to assess the efficacy and safety of tubeless PCNL in comparison to standard PCNL. METHODS A randomized control trial study was conducted in Sri Rama Chandra Medical Centre, Chennai, over a period of 2 years (i.e., between February 2016 to March 2018). A total of 220 patients were divided equally into two groups and were randomised into: Group A (undergoing tubeless PCNL; n = 110) and Group B (undergoing standard PCNL; n = 110). Factors that were evaluated included operative time, hospital stay, drop in haemoglobin, blood transfusion required, analgesics required, ancillary procedure performed, stone clearance and complications. The qualitative variables were analysed by chi-square test and quantitative variables were analysed by the student's t test. A p-value <0.05 was considered as statistically significant. RESULTS There was no statistically significant difference between the two study groups for patient age, gender, stone location, associated stone disorders, and co-morbidities. Majority of the study participants were male i.e., 56.4 % in Group A and 55.5 % in Group B. The mean age in group A was 42.45 ± 14.13 years and in group B was 45.44 ± 12.12 years. There was statistically significant less operative time, less hospital stay, smaller drop in haemoglobin and less analgesic requirement in Group A (p-value < 0.0001) as compared to Group B. There was no significant difference between the study groups with respect to stone clearance, complications, requirement of blood transfusion and ancillary procedures performed. CONCLUSIONS The present study proves the advantages of tubeless PCNL. It has significantly less operative time, short hospital stays, less drop-in haemoglobin and less requirement of postoperative analgesic in comparison with standard PCNL. Thus, tubeless PCNL is effective and safe in selected group of individuals.