The comparison of the degree of apoptosis in ovaries and fallopian tubes between two different surgical interventions for tubal ligation: A rat model

Mümüşoğlu, Sezcan; Hacıvelioğlu, Servet; Karakoc-Sokmensuer, L.; Karataylı, Rengin; Süzer, Ayşegül; Kaymaz, Figen

doi:10.4274/jtgga.2016.0192

Cited by 1 publication

(1 citation statement)

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“…Adolescent male rats were housed in groups of four per cage until postnatal day (PND) 70 when animals of the same treatment were pair-housed. Adult Sprague Dawley male rats 400–450 g (Charles River Laboratories, Calco, Italy), used as residents for the SDS protocol, were housed with a sterile, but sexually receptive adult Sprague Dawley female rat to enhance their aggressiveness towards the intruders [ 45 ]. All the experiments were performed during the light phase of the cycle (10:00 AM–3:00 PM) and were in compliance with the ARRIVE guidelines, the Directive 2010/63/EU of the European Parliament, the D. L. 26/2014 of Italian Ministry of Health, and approved by the Italian Ministry of Health.…”

Section: Methodsmentioning

confidence: 99%

Social Defeat Stress during Early Adolescence Confers Resilience against a Single Episode of Prolonged Stress in Adult Rats

Mancini

Marchetta

Pignani

et al. 2021

Cells

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Early-life adverse experiences (first hit) lead to coping strategies that may confer resilience or vulnerability to later experienced stressful events (second hit) and the subsequent development of stress-related psychopathologies. Here, we investigated whether exposure to two stressors at different stages in life has long-term effects on emotional and cognitive capabilities, and whether the interaction between the two stressors influences stress resilience. Male rats were subjected to social defeat stress (SDS, first hit) in adolescence and to a single episode of prolonged stress (SPS, second hit) in adulthood. Behavioral outcomes, hippocampal expression of brain-derived neurotrophic factor, and plasma corticosterone levels were tested in adulthood. Rats exposed to both stressors exhibited resilience against the development of stress-induced alterations in emotional behaviors and spatial memory, but vulnerability to cued fear memory dysfunction. Rats subjected to both stressors demonstrated resilience against the SDS-induced alterations in hippocampal brain-derived neurotrophic factor expression and plasma corticosterone levels. SPS alone altered locomotion and spatial memory retention; these effects were absent in SDS-exposed rats later exposed to SPS. Our findings reveal that exposure to social stress during early adolescence influences the ability to cope with a second challenge experienced later in life.

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Section: Methodsmentioning

confidence: 99%