The comparison of the effect of soybean and fish oil on supplementation on menopausal symptoms in postmenopausal women: A randomized, double-blind, placebo-controlled trial

Purzand, Bahareh; Rokhgireh, Samaneh; Zanjani, Mansoore Shabani; Eshraghi, Nooshin; Mohamadianamiri, Mahdiss; Esmailzadeh, Arezoo; Alkatout, İbrahim; Gitas, Georgios; Allahqoli, Leila

doi:10.1016/j.ctcp.2020.101239

Cited by 12 publications

(32 citation statements)

References 33 publications

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“…The participants were allocated to three groups in three studies [23][24][25] and two groups in seven studies. [25][26][27][28][29][30][31] In all of the studies, the control group received a placebo.…”

Section: Methodsmentioning

confidence: 99%

“…Nine studies were conducted in Iran [23][24][25][26][27][28][29][30][31] and one study in the United States. 31…”

Section: Study Locationmentioning

confidence: 99%

“…27 In two studies, 28,29 the participants received 850 mg vitamin E and omega-3 capsules per day for 12 weeks. In three studies, 24,25,31 the participants received 1000 mg omega-3 capsules per day for 12 weeks. In one study, 30 the participants received 300 mg fish oil supplement per day for 8 weeks.…”

Section: Types Of Interventionsmentioning

confidence: 99%

“…The frequency of hot flushes was evaluated based on daily records in eight studies. 22,[24][25][26][27][29][30][31] It was not mentioned in two studies. 24,29 The Menopause Rating Scale (MRS) was used in three studies to assess the intensity of hot flushes.…”

Section: Outcome Measuresmentioning

confidence: 99%

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The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

2022

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This systematic review was conducted to investigate the effects of vitamin E and omega-3 used alone and in combination on the frequency and intensity of hot flushes (primary outcomes) and adverse effects (secondary outcome) in menopausal women. English and Persian databases were searched until March 18, 2021. The quality of the published papers was evaluated using Cochrane Handbook and the meta-analysis was conducted in RevMan 5.3. Heterogeneity was assessed using I2. In cases with substantial heterogeneity, a random effects model was used instead of a fixed effects model. A total of 387 papers were obtained from the databases. Finally, 10 papers with a sample size of 1100 participants entered the systematic review and a meta-analysis was conducted on nine of them. The results of the meta-analysis of two studies indicated that using vitamin E and omega-3 in combination significantly reduced the intensity of hot flushes compared to the placebo (mean difference (MD): −0.35; 95% CI: −0.48 to −0.21). The mean frequency (MD: −0.50; 95% CI: −1.58 to 0.58) and intensity (SMD: −0.61; 95% CI: −1.50 to 0.29) of hot flushes in the omega-3 group and the frequency of hot flushes (SMD: −0.21; 95% CI: −0.47 to 0.04) in the vitamin E group showed no significant differences with the placebo. No serious adverse effects were reported in the studies. Given the low number of RCTs, more clinical trials with larger sample size are required.

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Section: Methodsmentioning

confidence: 99%

“…Nine studies were conducted in Iran [23][24][25][26][27][28][29][30][31] and one study in the United States. 31…”

Section: Study Locationmentioning

confidence: 99%

Section: Types Of Interventionsmentioning

confidence: 99%

Section: Outcome Measuresmentioning

confidence: 99%

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The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

2022

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“…Positive effects and safe administration of omega-3 supplementation in the control of menopausal symptoms and mood changes in non-cancerous postmenopausal women have been addressed in several studies [9][10][11][12]. However, there is still no enough evidences on positive effects of omega-3 supplementation on breast cancer patients' undergoing treatment with anti-hormone therapy specially in term of mood and sleep disorders.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 in The Treatment of Mood and Sleep Disorders Induced by Hormone Therapy in Women with Breast Cancer: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

Nourosi

Naghsh

zadeh

et al. 2021

Preprint

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Purpose This study was performed to investigate the effect of omega-3 on the treatment of mood and sleep disorder induced by menopausal complications due to hormone therapy in patients with breast cancer. Methods A placebo, double-blind and controlled trial was designed in oncology-hematology outpatient’s clinic of Omid Hospital, Isfahan, Iran. First, sixty patients were screened by hospital anxiety and depression scale (HADS) for any baseline mood disorders and then divided into either intervention group who had received 2 grams’ omega-3 daily for 4 weeks or identical placebo. Then, the patients were considered to assess by center for epidemiological studies-depression scale (CES-D), profile of mood states (POMS), and Pittsburgh sleep quality index (PSQI) questionnaires at the baseline and after 4-week follow-up. Results Findings showed that the mean scores of CES-D (P = 0.002), POMS (P = 0.03), and PSQI (P = 0.04) were significantly lower in the intervention group than the control group. In the intervention group, mean scores of CES-D (P <0.001), POMS (P <0.001), and PSQI (P = 0.003) were significantly lower in post-intervention than pre-intervention. Mean changes in scores of CES-D (P = 0.01), POMS (P = 0.001), and PSQI (P = 0.02) were significantly higher in the intervention group than the control group. Conclusion Our findings revealed that omega-3 supplementation have the potential to reduce mood disorders as well as to improve sleep quality in terms of subjective sleep quality, delay in falling asleep, sleep delay, and sleep disturbance in patients with breast cancer.

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Efficacy of plant‐derived dietary supplements in improving overall menopausal symptoms in women: An updated systematic review and meta‐analysis

Oh,

Park,

Park

et al. 2024

Phytotherapy Research

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This updated systematic review and meta‐analysis aims to confirm the effectiveness of plant‐based supplements in improving overall menopausal symptoms and vasomotor symptoms. A systematic review of the literature was conducted by searching the PubMed/MEDLINE, Web of Science, EMBASE, and CENTRAL databases up to June 2022. Randomized placebo‐controlled clinical trials that evaluated the effects of dietary supplements on menopausal symptoms were included. Outcome measures included daily hot flash frequency, Kupperman's index, Menopause Rating Scale, and Greene Climacteric Scale. Pooled data were analyzed using a fixed‐effects model and expressed as a weighted mean difference with a 95% confidence interval for continuous outcomes. For qualitative assessment, 67 studies were selected. For quantitative assessment, 54 reports were obtained from 61 studies. The study participants were peri‐ or postmenopausal women aged 38–85, most of whom experienced hot flashes as a menopausal symptom. The investigational products included 28 soy‐derived, 6 red clover‐derived, and 28 other plant‐derived supplements. Qualitative assessment revealed that approximately 76% of the studies were generally of fair or good quality, whereas 24% were of low quality. Meta‐analysis results indicated significant improvements in all questionnaire scores, including hot flash frequency, in the dietary supplement group compared with the placebo group. Comprehensive evaluation using different questionnaire tools showed that the various plant‐derived dietary supplements can significantly alleviate menopausal symptoms. However, further rigorous studies are needed to determine the association of plant‐derived dietary supplements with menopausal health because of the general suboptimal quality and heterogeneous nature of current evidence.

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The comparison of the effect of soybean and fish oil on supplementation on menopausal symptoms in postmenopausal women: A randomized, double-blind, placebo-controlled trial

Cited by 12 publications

References 33 publications

The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

Omega-3 in The Treatment of Mood and Sleep Disorders Induced by Hormone Therapy in Women with Breast Cancer: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

Efficacy of plant‐derived dietary supplements in improving overall menopausal symptoms in women: An updated systematic review and meta‐analysis

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