The comparison of two forms of sodium and potassium and chloride versus sulfur in the Dietary Cation-Anion Difference equation: Effects on acid-base status and mineral balance in sedentary horses

Baker, L.A.; Topliff, D.R.; Freeman, D.W.; Teeter, R. G.; Stoecker, Barbara J.

doi:10.1016/s0737-0806(98)80585-6

Cited by 14 publications

(11 citation statements)

References 26 publications

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“…horses developing exertional rhabdomyolysis during treadmill exercise. 12,33 These changes reflect alkalemia induced by the systemic generation of HCO 3 following absorption of Na + from the gastrointestinal tract in exchange for hydrogen (H + ). 12,33 These changes reflect alkalemia induced by the systemic generation of HCO 3 following absorption of Na + from the gastrointestinal tract in exchange for hydrogen (H + ).…”

Section: Low Dcab Medium Dcab High Dcab Low Dcab Medium Dcab High Dcamentioning

confidence: 99%

“…12,13 The DCAB refers to the difference in the concentration of strong cations and strong anions in a diet. 12,13 The DCAB refers to the difference in the concentration of strong cations and strong anions in a diet.…”

mentioning

confidence: 99%

“…12,13 The DCAB refers to the difference in the concentration of strong cations and strong anions in a diet. 12,16 The effect of DCAB on acid-base and electrolyte variables has been thoroughly investigated in dairy cattle, in which diets with low DCAB have been proven to significantly reduce the incidence of postparturient hypocalcemia via alterations in calcium metabolism. Likewise, a diet with a low DCAB contains a higher proportion of strong anions, such as chloride and sulfur, in relation to cations, such that the DCAB may approach 0 or even a negative value.…”

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confidence: 99%

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Plasma and urine electrolyte and mineral concentrations in Thoroughbred horses with recurrent exertional rhabdomyolysis after consumption of diets varying in cation-anion balance

McKenzie

Valberg

Godden

et al. 2002

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Section: Low Dcab Medium Dcab High Dcab Low Dcab Medium Dcab High Dcamentioning

confidence: 99%

mentioning

confidence: 99%

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Plasma and urine electrolyte and mineral concentrations in Thoroughbred horses with recurrent exertional rhabdomyolysis after consumption of diets varying in cation-anion balance

McKenzie

Valberg

Godden

et al. 2002

ajvr

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“…The influence of DCAD and non-structural carbohydrate on acid-base balance, on mineral homeostasis and mineral excretion has received attention from equine researchers [72,84,85]. Rations with a DCAD less than 100 mEq/kg feed DM are acidogenic and result in enhanced calcium excretion.…”

Section: Nutrition and Acid-base Status In Athletic Horsesmentioning

confidence: 99%

Animal nutrition and acid-base balance

Riond¹

2001

European Journal of Nutrition

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In domestic animals, acid-base balance may be influenced by nutrition. The major research effort in this area has been made on the prevention of hypocalcemic postparturient paresis in dairy cows. This disorder is caused by the sudden increase of calcium secretion into the colostrum. The manipulation of the dietary cation-anion difference makes it possible to maintain the cows in metabolic acidosis during the critical period that precedes calving, presumably via a mechanism that involves the strong ion difference in the extracellular fluid. As a consequence the mobilization of calcium is enhanced and the incidence of the disorder is decreased. Conversely, a dietary induced metabolic alkalosis leads to a more severe degree of hypocalcemia and the incidence of the disease is increased. The underlying mechanisms of the prevention are only partially understood. Nevertheless, this preventive method is already widely applied in practice. Nutrition effects on acid-base balance also influence growth and food intake in higher vertebrates and fish. As a consequence, the incidence of developmental orthopedic diseases in fast-growing domestic animal species may be affected. Also, the bone mineral content of athletic horses may be influenced by dietary induced modification of the acid-base status. The mineral loss due to metabolic acidosis may lead to an increase in the incidence of stress fractures. This overview should give insight into relevant aspects of nutrition and acid-base balance in domestic animal species.

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“…Sometimes expressed as dietary cation-anion balance (DCAB) to denote the effects of strong ions on the proton concentration in aqueous solution, a higher DCAB tends to promote a metabolic alkalosis, which in turn encourages calcium carbonate precipitation and hence stronger eggshells. Feeding a high-DCAB/alkalinizing diet to competitive horses has been proposed as a means of counteracting the metabolic acidosis associated with the lactic acidemia that occurs during intense exercise, thereby improving their endurance and performance [2].…”

Section: Calcium Bioavailability and Efficiency Of Utilizationmentioning

confidence: 99%

Dietary instead of pharmacological management to counter the adverse effects of physiological adaptations to space flight

Fettman

2000

Pflügers Arch - Eur J Physiol

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The development of pharmacological countermeasures to the adverse effects of physiological adaptation to microgravity has received relatively more attention than alternatives such as dietary management. The manipulation of dietary cation-anion balance, and its subsequent effects on acid-base metabolism, have been routinely used for some time in managing domestic animal health. More recently, dietary intake by humans of alkalinizing potassium salts has been demonstrated to exert profound beneficial effects on calcium balance, bone mineralization, predisposition to calcium oxalate nephrolithiasis, and overall nitrogen balance. Dietary sodium restriction has also been shown to improve calcium balance, bone mineralization, and the effectiveness of neurohumoral defenses against orthostatic hypotension. It is proposed that these simple alterations in the astronauts' diets may be easily implemented to lessen the adverse effects of physiological adaptations to space flight, and to enhance or even replace prescribed pharmacological counter-measures.

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The comparison of two forms of sodium and potassium and chloride versus sulfur in the Dietary Cation-Anion Difference equation: Effects on acid-base status and mineral balance in sedentary horses

Cited by 14 publications

References 26 publications

Plasma and urine electrolyte and mineral concentrations in Thoroughbred horses with recurrent exertional rhabdomyolysis after consumption of diets varying in cation-anion balance

Plasma and urine electrolyte and mineral concentrations in Thoroughbred horses with recurrent exertional rhabdomyolysis after consumption of diets varying in cation-anion balance

Animal nutrition and acid-base balance

Dietary instead of pharmacological management to counter the adverse effects of physiological adaptations to space flight

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