The comparison of umbilical cord arterial blood lactate and pH values for predicting short-term neonatal outcomes

Einikytė, Rūta; Sniečkuvienė, Vilija; Ramašauskaitė, Diana; Panaviene, Jurate; Paliulytė, Virginija; Opolskiene, G.; Kazėnaitė, Edita

doi:10.1016/j.tjog.2017.10.007

Cited by 19 publications

(20 citation statements)

References 17 publications

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“…36 Many similar studies have observed that both cord blood lactate and pH had almost equal significance in prediction of overall neonatal outcome. 35,40 Hence, Umbilical cord arterial blood pH and LDH levels were significantly associated with poor Apgar score of newborns at birth and correlates well with NICU admission, neonatal complications and deaths in women with hypertensive disorders of pregnancy.…”

Section: Tablementioning

confidence: 84%

Role of umbilical cord arterial pH and lactate in newborn assessment of term antenatal women with hypertensive disorders of pregnancy

Kumar

Yadav

2020

Clinical Epidemiology and Global Health

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To know role of cord arterial blood pH and lactate dehydrogenase levels in neonatal outcome assessment. Methods: Present observational study was conducted in Obstetrics and Gynecology department of a rural tertiary center of Northern India over 6 months (July-January 2019) on 155 term (≥37-≤42 weeks) antenatal women with hypertensive disorders of pregnancy fulfilling inclusion criteria. Immediately after delivery, arterial blood sample was drawn from doubly clamped 10-12 cm long umbilical cord in pre-heparinized insulin syringe, which was sent for pH estimation and 0.5 ml in lithium heparin tube for lactate dehydrogenase levels. One-and 5-min neonatal Apgar score was noted by pediatrician. Cord blood pH and lactate levels were then compared with overall neonatal outcome. Statistical analysis was done using SPSS-22 version. Results: Mean values of umbilical cord arterial pH and LDH was 7.2 ± 0.1 and 449.5 ± 562.9 U/L respectively. Significantly low mean cord blood pH (7.03 ± 0.12) and high LDH levels (939.74 ± 781.75 U/L) were observed in neonates of eclamptic mothers (p = 0.00). Mode of delivery had significant effects on cord blood parameters with significantly low pH and elevated LDH levels seen in neonates delivered by emergency LSCS for fetal distress (p < 0.05). Cord blood LDH levels were more significantly associated with NICU admission, neonatal morbidity and mortality. Cord blood LDH was a better predictor of neonatal outcome with 100% sensitivity and 79.73% specificity. Conclusion: Cord arterial blood lactate dehydrogenase levels were better predictor of overall neonatal outcome.

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Section: Tablementioning

confidence: 84%

Role of umbilical cord arterial pH and lactate in newborn assessment of term antenatal women with hypertensive disorders of pregnancy

Kumar

Yadav

2020

Clinical Epidemiology and Global Health

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“…Our inclusion criteria were full-term neonates admitted to the NICU during their rst 6 hours of life and met the diagnostic criteria speci ed by (AAP) [8] which are: base de cit > 10, APGAR scores ≤ ve at 10 minutes with a continued need for resuscitation, Metabolic acidosis with pH < 7.0, and Presence of primary or secondary apnea. On the other hand, we excluded every neonate aged older than 1 day, or born with any errors such as: errors of metabolism, genetic disorders, congenital neurologic disorders, or medication effect.…”

Section: Inclusion Criteriamentioning

confidence: 99%

Study of blood levels of Lactate, Vitamin D and Nucleated Red Blood Cells for early prediction of Hypoxic–Ischemic Encephalopathy: A cross-sectional case-control study

Saad¹,

Thabet²,

Soliman³

et al. 2021

Preprint

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Background Perinatal asphyxia is a serious medical condition in which there is a lack of oxygen or blood flow during, or even after the labor process. Methods A cross-sectional case-control study was conducted on 20 neonates with HIE comprising the cases (APGAR ≤ 5) and another 20 neonates representing the control group with their age, sex, and weight matched, admitted to NICU. Sarnat score was used to assess the severity of HIE. Results Venous blood levels of lactate and nucleated red blood cells per 100 white blood cells (NRBC/100 WBC) counts were significantly higher in HIE neonates than in the control group with a highly significant difference (p-value < 0.001). While serum Vitamin D was significantly lower in the HIE group than in the control (p-value < 0.001). Conclusion Serum lactate level, vitamin D level and NRBCs/100 WBCs might be used as biomarkers in the early prediction of HIE.

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“…As a result of hypoxia and tissue hypo-perfusion, the regular energy requirement cannot be sustained from aerobic metabolism, so that tissues go through anaerobic metabolism to get their energy requirement and hence, it re ects the increase in the production and accumulation of lactate in blood which in turn can detect tissue hypoxia at a very early stage [7].…”

Section: Introductionmentioning

confidence: 99%

Study of Lactate, Vitamin D and Nucleated Red Blood Cells for Early Prediction of Hypoxic–Ischemic Encephalopathy: A Cross-Sectional Case-Control Study

Saad

Thabet

Soliman

et al. 2021

Preprint

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Objective and backgroundPerinatal asphyxia is a serious medical condition in which there is a lack of oxygen or blood flow during, or even after the labor process. So this study aimed to study serum blood levels of Lactate, vitamin D and count of Nucleated Red Blood Cells (NRBCs) per 100 White Blood Cells (WBCs) as early biological predictors of Hypoxic–Ischemic Encephalopathy (HIE) after birth Asphyxia. MethodsA cross-sectional case-control study was conducted on 20 neonates with HIE comprising the cases (APGAR ≤ 5) and another 20 neonates representing the control group with their age, sex, and weight matched, admitted to NICU from March 2020 to the end of September 2020. Venous blood samples for lactate, vitamin D and nucleated RBCs were drawn after birth and sent for analysis. Sarnat score was used to assess the severity of HIE. ResultsVenous blood levels of lactate and nucleated red blood cells per 100 white blood cells (NRBC/100 WBC) counts were significantly higher in HIE neonates than in the control group with a highly significant difference (P-value <0.001). While serum Vitamin D was significantly lower in the HIE group than in the control (P-value <0.001). ConclusionSerum lactate level, vitamin D level and NRBCs/100 WBCs might be used as biomarkers in the early prediction of HIE.

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The comparison of umbilical cord arterial blood lactate and pH values for predicting short-term neonatal outcomes

Abstract: Umbilical cord arterial lactate and pH predicted short-term neonatal outcomes with similar efficacies.

Cited by 19 publications

References 17 publications

Role of umbilical cord arterial pH and lactate in newborn assessment of term antenatal women with hypertensive disorders of pregnancy

Role of umbilical cord arterial pH and lactate in newborn assessment of term antenatal women with hypertensive disorders of pregnancy

Study of blood levels of Lactate, Vitamin D and Nucleated Red Blood Cells for early prediction of Hypoxic–Ischemic Encephalopathy: A cross-sectional case-control study

Study of Lactate, Vitamin D and Nucleated Red Blood Cells for Early Prediction of Hypoxic–Ischemic Encephalopathy: A Cross-Sectional Case-Control Study

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