The comparison of visfatin levels of gingival crevicular fluid in systemic lupus erythematosus and chronic periodontitis patients with healthy subjects

Rezaei, Maryam; Bayani, Mojtaba; Tasorian, Baharak; Mahdian, Soroush

doi:10.1007/s10067-019-04708-w

Cited by 11 publications

(16 citation statements)

References 19 publications

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“…However, a longitudinal follow-up is important to accurately distinguish the causes of high tooth loss due to periodontal or other dental problems, including caries, in SLE patients. 30 Regarding periodontal diagnosis, we observed a similar periodontal condition between the Periodontitis and SLE + periodontitis groups, as verified in other investigations, 8,9 contrasting to a worse periodontal condition in SLE patients found by others. 10 Moreover, SLE patients without periodontitis showed a protective factor in the number of bleeding sites in comparison to SLE patients with periodontitis, in agreement with a previous study.…”

Section: Discussionsupporting

confidence: 84%

“…3 Increasing epidemiologic evidence has shown a high prevalence and an increased risk of periodontitis in SLE patients. 4,5 Conversely, the literature shows controversial data concerning periodontal status in SLE patients, and some studies reported a milder, 6 a similar, [7][8][9] and a more severe form of periodontitis in SLE patients. 10 Moreover, interventional studies have demonstrated the beneficial effect of periodontal therapy in reducing SLE disease activity 11 and ameliorating the response to treatment.…”

Section: Introductionmentioning

confidence: 99%

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DNMT3B (rs2424913) polymorphism is associated with systemic lupus erythematosus alone and with co-existing periodontitis in a Brazilian population

et al. 2022

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DNMT3B (rs2424913) polymorphism is associated with systemic lupus erythematosus alone and with coexisting periodontitis in a Brazilian populationThe association between Periodontitis and Systemic Lupus Erythematosus (SLE) has been primarily based on their similar pathophysiology and both are associated with genetic polymorphisms. Objectives: To investigate an association between the methylation-related gene polymorphisms DNMT3B (rs2424913) and MTHFR (rs1801133) to Systemic Lupus Erythematosus (SLE) and Periodontitis. Methodology: In total, 196 individuals of all genders aged 24 to 60 years old were allocated into four groups based on their systemic and periodontal status, namely: Healthy control (n=60), periodontitis (n=51), SLE (n=47), and SLE + periodontitis (n=38). Individuals with SLE were stratified according to disease activity (SLEDAI) in inactive or active. We performed polymorphism analysis using PCR-RFLP with genomic DNA from mouthwash. We analyzed data using Fisher's Exact, Chi-square test, and regression models. Results: Periodontal status were similar in subjects with periodontitis alone and combined with SLE. SLE patients with periodontitis had a longer SLE diagnosis than SLE only (p=0.001). For DNMT3B polymorphism, the periodontitis, SLE, and Inactive SLE + periodontitis groups showed a higher frequency of T allele and TT genotypes compared to healthy controls (p<0.05). Regression analyses showed that the TT genotype is a strong risk factor for periodontitis (OR=4.53; CI95%=1.13-18.05) and also for SLE without periodontitis (OR=11.57; CI95%=3.12-42.84) and SLE with periodontitis (OR=5.27; CI95%=1. 25-22.11) when compared to control. Conclusion: SLE patients with periodontitis had a longer length of SLE diagnosis. The DNMT3B (rs2424913) polymorphism was associated with periodontitis and SLE alone or combined with periodontitis. Our study contributes to understanding the genetic mechanisms involved in periodontitis and SLE susceptibility.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

DNMT3B (rs2424913) polymorphism is associated with systemic lupus erythematosus alone and with co-existing periodontitis in a Brazilian population

et al. 2022

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“…The majority of the observational studies included in this review presented with a moderate risk of bias 2,3,25–35 , one with high 36 and three with low risk of bias 37–39 (Supplementary , Appendix , Table ). Among the main factors behind study bias we have identified: definition adequacy, representativeness of the cases, selection and definition of the controls, representativeness of exposed cohort and demonstration that outcome of interest was not present at start of study.…”

Section: Resultsmentioning

confidence: 99%

Periodontitis and Systemic Lupus Erythematosus: A systematic review and meta‐analysis

Hussain

Leira

Zehra

et al. 2021

J of Periodontal Research

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“…After screening the title and abstract of these studies by two authors independently, 58 studies that did not meet the inclusion criteria were excluded and the full text of the remaining 33 studies was examined. Finally, sixteen studies [16,17,19,[24][25][26][27][28][29][30][31][32][33][34][35][36] were included in the meta-analysis. Seventeen studies that were impossible to include in the meta-analysis are presented in S2 Table with details and reasons [14,15,18,[37][38][39][40][41][42][43][44][45][46][47][48][49][50] and can be considered as qualitative data.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Periodontal disease and visfatin level: A systematic review and meta-analysis

Bayani,

Heidari,

Almasi-Hashiani

2023

PLoS ONE

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Visfatin is considered an inflammatory biomarker in periodontal disease (PD). In this meta-analysis, we aimed to evaluate the relationship between Visfatin biomarker level with PD. In this study, Medline, Scopus, Web of Science, and Google Scholar were searched. We included studies that examined visfatin levels in samples from healthy people and periodontal disease until March 2023. The quality of the selected articles was evaluated using the Newcastle-Ottawa assessment scale. Depending on heterogeneity of studies, random-effects or fixed-effect models were used to pool results and report the standardized mean difference (SMD). After screening the retrieved papers, the related data were extracted. A total of 159 studies were identified, and 16 studies were included in the meta-analysis. In 9 studies, the SMD of visfatin level of gingival crevicular fluid (GCF) in patients with chronic periodontitis (CP) and healthy individuals was 4.32 (p<0.001). In 6 studies, the SMD of salivary visfatin level in patients with CP and healthy individuals was 2.95 (p = 0.004). In addition, in five studies, the SMD of serum visfatin level in patients with CP and healthy individuals was 7.87 (p<0.001). Therefore, Visfatin levels in serum, saliva, and GCF of patients with CP were increased in comparison to healthy individuals. Comparison of visfatin levels in saliva of gingivitis patients and healthy individuals showed a significant increase of visfatin in gingivitis patients (SMD:0.57, P = 0.018), but no significant difference was observed in the mean GCF visfatin level of gingivitis patients and healthy individuals (SMD:2.60, P = 0.090). In addition, the results suggested that there is no difference between gingivitis cases compared to CP patients (SMD:3.59, P = 0.217). Visfatin levels in GCF, serum, and saliva have the potential to be used as a diagnostic biomarker of periodontitis.

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The comparison of visfatin levels of gingival crevicular fluid in systemic lupus erythematosus and chronic periodontitis patients with healthy subjects

Cited by 11 publications

References 19 publications

DNMT3B (rs2424913) polymorphism is associated with systemic lupus erythematosus alone and with co-existing periodontitis in a Brazilian population

DNMT3B (rs2424913) polymorphism is associated with systemic lupus erythematosus alone and with co-existing periodontitis in a Brazilian population

Periodontitis and Systemic Lupus Erythematosus: A systematic review and meta‐analysis

Periodontal disease and visfatin level: A systematic review and meta-analysis

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