The comparison of Zn(II) arginine dithiocarbamate cytotoxicity in T47D breast cancer and fibroblast cells

Prihantono, Prihantono; Irfandi, Rizal; Raya, Indah

doi:10.3233/bd-219008

Cited by 9 publications

(9 citation statements)

References 9 publications

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“…Among them, USP8 , one of the three prognostic risk ac4C genes obtained from the previous analysis, is a drug target, and corresponded to the drug Zn(II). Zn(II) has an antiproliferative effect on human cancer cells [ 31 ] and had stronger active cytotoxicity in inducing morphological changes in breast cancer cell lines compared with cisplatin, and was non-toxic to fibroblasts [ 32 ]. The network of differential ac4C genes with drug targets is shown in Figure 6 A, in which the orange and purple nodes are 79 differential ac4C genes, the green nodes are drug names, and the purple nodes are prognostic risk genes related to NAT10.…”

Section: Resultsmentioning

confidence: 99%

Revealing the Potential Markers of N(4)-Acetylcytidine through acRIP-seq in Triple-Negative Breast Cancer

Zhang

Zeng

Wang

et al. 2022

Genes

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Understanding the causes of tumorigenesis and progression in triple-receptor negative breast cancer (TNBC) can help the design of novel and personalized therapies and prognostic assessments. Abnormal RNA modification is a recently discovered process in TNBC development. TNBC samples from The Cancer Genome Atlas database were categorized according to the expression level of NAT10, which drives acetylation of cytidine in RNA to N(4)-acetylcytidine (ac4C) and affects mRNA stability. A total of 703 differentially expressed long non-coding RNAs (lncRNAs) were found between high- and low-expressed NAT10 groups in TNBC. Twenty of these lncRNAs were significantly associated with prognosis. Two breast cancer tissues and their paired normal tissues were sequenced at the whole genome level using acetylated RNA immunoprecipitation sequencing (acRIP-seq) technology to identify acetylation features in TNBC, and 180 genes were significantly differentially ac4c acetylated in patients. We also analyzed the genome-wide lncRNA expression profile and constructed a co-expression network, containing 116 ac4C genes and 1080 lncRNAs. Three of these lncRNAs were prognostic risk lncRNAs affected by NAT10 and contained in the network. The corresponding reciprocal pairs were “LINC01614-COL3A1”, “OIP5-AS1-USP8”, and “RP5-908M14.9-TRIR”. These results indicate that RNA ac4c acetylation involves lncRNAs and affects the tumor process and prognosis of TNBC. This will aid the prediction of drug targets and drug sensitivity.

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Section: Resultsmentioning

confidence: 99%

Revealing the Potential Markers of N(4)-Acetylcytidine through acRIP-seq in Triple-Negative Breast Cancer

Zhang

Zeng

Wang

et al. 2022

Genes

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“…These results demonstrate a considerable cytotoxic effect of the complex chemical Zn(II) arginine dithiocarbamate on T47D cancer cells but a negligible cytotoxic effect on fibroblast cells (healthy cells). Additionally, it is possible to demonstrate that the Zn(II) arginine dithiocarbamate complex has a lower IC 50 value than cisplatin, proving that the latter compound is less hazardous [51].…”

Section: ■ Cytotoxic Action Of Zn(ii) Dithiocarbamate Complexes Again...mentioning

confidence: 99%

“…Additionally determined were the cisplatin values and the complex selectivity index (SI). SI stands for the ratio of a substance's IC 50 toxicity to a cancer cell line or a cancer variant of a normal cell line to a normal cell line (in this example, MRC5) (in this case, MRC5-SV2) [51]. SI > 1 indicates a more selective molecule (desirable) for cancer cells, whereas SI 1 indicates a substance that is more damaging to normal cells than cancer cells (undesired).…”

Section: ■ Cytotoxic Action Of Zn(ii) Dithiocarbamate Complexes Again...mentioning

confidence: 99%

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Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes

et al. 2022

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The importance of essential metal ions and their metal complexes in the creation of prospective medical therapies has long been recognized. In chemistry, molecular biology, and medicinal fields; the interaction of metal complexes with DNA has been a subject of study. The dithiocarbamate essential metal complex is described extensively in the literature for its various benefits and advantages. With proper use of ligands, it is proven to increase the cytotoxic activity of metal complexes against cancer cells. Some researches have shown significant progress regarding the biological activities of the dithiocarbamate essential metal complex as antimicrobial, antioxidant, and anticancer agents. Metal complexes form complexes with dithiocarbamate ligands with unique structural variations. In this study, we presented an overview of the cytotoxic effects of some dithiocarbamate essential metal complexes on cancer cells, as well as fresh approaches to the design of essential metal-based therapeutics containing dithiocarbamate and molecular targets in cancer therapy. This review may provide an update on recent developments in the medicinal use of essential metals with dithiocarbamate ligands, carried out to identify recent relevant literature. Finally, we predict that the essential metal complexed with dithiocarbamate can be a new breakthrough in the future development of cancer drugs.

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“…Dithiocarbamate compounds are synthesized from the reaction of primary amines such as isoleucine, carbon disulfide (CS2) and alkyl halides under catalyzed conditions or sometimes using a base. Dithiocarbamate is important because of its wide application in medicinal chemistry (Shinde et al, 2020;Prihantono et al, 2021). Dithiocarbamate is a metal chelating chemical that has a wide range of medical applications.…”

Section: Research Articlementioning

confidence: 99%

A New Complex Design of Fe (II) Isoleucine Dithiocarbamate as a Novel Anticancer and Antivirus against SARSCOV-2 (COVID-19)

Irfandi

Riswandi

Raya

et al. 2022

Asian Pac J Cancer Prev

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Background: This study was carried out to synthesize a new complex of Fe(II) with isoleucine dithiocarbamate ligand and to determine its potential as an anticancer and antiviral agent for SARSCOV-2. Methods: The synthesized complexes were then characterized by UV-vis and FT-IR spectroscopy and their melting points. The value of the conductivity of the complex compound is also determined. Anti-cancer activity was tested in vitro and molecular docking. Its potential as an antiviral against SARSCOV-2 was also carried out by molecular docking. Pharmacokinetics/ ADMET properties were also carried out on the complex. Result: Spectral results showed the successful synthesis of Fe(II) isoleucine dithiocarbamate complex. The complex produced UV-vis spectra at 268 and 575 nm, and the IR data at 399-599 cm-1 showed the coordination between the Fe(II) atoms with sulphur, nitrogen and oxygen of the isoleucine dithiocarbamate ligand. Fe(II) isoleucine dithiocarbamate had a cytotoxicity effect on the MCF-7 cell line (IC 50 =613 µg/mL). The complex significantly caused morphological changes in the breast cancer cell line, finally leading to cell apoptosis. Conclusion: Cytotoxic test of Fe(II) isoleucine dithiocarbamate showed moderate anticancer activity on MCF-7 cancer cells and showed antiviral activity against SARSCOV-2 by interfering with spike glycoprotein -ACE2 receptors, and inhibiting major proteases and 3Clpro.

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The comparison of Zn(II) arginine dithiocarbamate cytotoxicity in T47D breast cancer and fibroblast cells

Cited by 9 publications

References 9 publications

Revealing the Potential Markers of N(4)-Acetylcytidine through acRIP-seq in Triple-Negative Breast Cancer

Revealing the Potential Markers of N(4)-Acetylcytidine through acRIP-seq in Triple-Negative Breast Cancer

Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes

A New Complex Design of Fe (II) Isoleucine Dithiocarbamate as a Novel Anticancer and Antivirus against SARSCOV-2 (COVID-19)

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