The compartmental distribution of knee osteoarthritis – a systematic review and meta-analysis

Stoddart, Jennifer C.; Dandridge, Oliver; Garner, Amy; Cobb, Justin; Arkel, Richard J. van

doi:10.1016/j.joca.2020.10.011

Cited by 86 publications

(53 citation statements)

References 55 publications

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“…However, the medial and lateral compartments of the knee are not equally likely to be affected. The incidence of isolated medial compartment knee osteoarthritis and isolated lateral compartment knee osteoarthritis were about3.3% and 0.6% respectively; the risk of developing osteoarthritis in the medial compartment was 5.4 times higher than that in the lateral compartment (20). This phenomenon is related to the bone settlement and bony structure asymmetry of the knee, with the lateral tibial plateau, but not the medial, having extra support from the fibula.…”

Section: Discussionmentioning

confidence: 99%

Association between the inclination angle of the proximal tibiofibular joint surface and medial compartment knee osteoarthritis

Huang¹,

Chen²,

Liu³

et al. 2021

Ann Palliat Med

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Background: Fibular support for the lateral tibial plateau through the proximal tibiofibular joint (PTFJ) results in nonuniform settlement of the tibial plateau in middle-aged and elderly persons and may lead to medial compartment knee osteoarthritis. However, the inclination angle of the PTFJ surface varies widely and may affect nonuniform settlement. The purpose of this case-control study was to assess the association between the inclination angle of the PTFJ surface and medial compartment knee osteoarthritis. Methods:The fibular inclination angle (FIA) and tibial inclination angle (TIA) of the PTFJ surface were measured using radiographs. Differences of FIA and TIA among groups were assessed with t tests and the odds ratios (ORs) for risk factors of medial compartment knee osteoarthritis were calculated with binary logistic regression analysis.Results: Forty patients and 40 control participants were included in this case-control study. Patients had both a lower FIA (P=0.005) and TIA (P=0.000) than the controls, and logistic regression analysis showed that FIA (OR =7.000) and TIA (OR =17.000) were risk factors for medial compartment knee osteoarthritis.Conclusions: A lower inclination angle of the PTFJ surface is associated with a risk of medial compartment knee osteoarthritis. Clinically, early prevention of medial compartment knee osteoarthritis should be considered for middle-aged and elderly persons with low PTFJ inclination angles.

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Section: Discussionmentioning

confidence: 99%

Association between the inclination angle of the proximal tibiofibular joint surface and medial compartment knee osteoarthritis

Huang¹,

Chen²,

Liu³

et al. 2021

Ann Palliat Med

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“…Knee osteoarthritis is a degenerative disease that affects 16% of the global population, 1 causing joint pain, stiffness, and reduced range of motion. The angle of the knee is highly relevant to the development, progression and distribution of knee osteoarthritis, [2][3][4] and for knee arthroplasty procedures which provide a treatment option for end-stage disease. [5][6][7] Globally, more than 3.2 million knee arthroplasties are performed each year 8 and for each of these procedures, a knee radiograph is taken to measure coronal knee alignment and plan the procedure.…”

Section: Introductionmentioning

confidence: 99%

Predicting Hip-Knee-Ankle and Femorotibial Angles from Knee Radiographs with Deep Learning

Arkel

Wang

Hall

et al. 2022

Preprint

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Knee alignment affects the development and surgical treatment of knee osteoarthritis. This research aimed to improve its automatic measurement from posteroanterior (PA) knee radiographs by using convolutional neural networks. Radiographs from the Osteoarthritis Initiative with corresponding femorotibial angle (FTA, N = 6149) and hip-knee-ankle angle (HKA, N = 2351) measurements, were split into training, validation, and test datasets in a 70:15:15 ratio. Separate models were developed for the prediction of FTA and HKA and their accuracy quantified. Heat maps were then used to identify the anatomical features within each image that most contributed to the predicted angles. High accuracy was achieved for FTA (mean absolute error 0.8°), and better than state-of-the-art accuracy was achieved for HKA (mean absolute error 1.7°). Heat maps for both models were concentrated on the knee anatomy and could prove a valuable tool for assessing prediction reliability in clinical application. Deep learning techniques enable fast, reliable and accurate predictions of both FTA and HKA from plain knee radiographs and could lead to cost savings for healthcare providers and reduced radiation exposure for patients.

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“…Knee osteoarthritis (OA), predominantly of the medial tibiofemoral compartment [ 1 ], is a highly prevalent and disabling global chronic disease affecting 1 in 5 people over the age of 40 [ 2 ]. Pathogenesis of medial knee OA is thought to be due in part to abnormal joint loading within the medial tibiofemoral compartment, with estimates of medial tibiofemoral contact force (MTCF) having been associated with structural disease progression in knee OA [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Tibiofemoral contact force differences between flat flexible and stable supportive walking shoes in people with varus-malaligned medial knee osteoarthritis: A randomized cross-over study

et al. 2022

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Objective To compare the effect of stable supportive to flat flexible walking shoes on medial tibiofemoral contact force (MTCF) in people with medial knee osteoarthritis and varus malalignment. Design This was a randomized cross-over study. Twenty-eight participants aged ≥50 years with medial knee osteoarthritis and varus malalignment were recruited from the community. Three-dimensional full-body motion, ground reaction forces and surface electromyograms from twelve lower-limb muscles were acquired during six speed-matched walking trials for flat flexible and stable supportive shoes, tested in random order. An electromyogram-informed neuromusculoskeletal model with subject-specific geometry estimated bodyweight (BW) normalized MTCF. Waveforms were analyzed using statistical parametric mapping with a repeated measures analysis of variance model. Peak MTCF, MTCF impulse and MTCF loading rates (discrete outcomes) were evaluated using a repeated measures multivariate analysis of variance model. Results Statistical parametric mapping showed lower MTCF in stable supportive compared to flat flexible shoes during 5–18% of stance phase (p = 0.001). For the discrete outcomes, peak MTCF and MTCF impulse were not different between the shoe styles. However, mean differences [95%CI] in loading impulse (-0.02 BW·s [-0.02, 0.01], p<0.001), mean loading rate (-1.42 BW·s-1 [-2.39, -0.45], p = 0.01) and max loading rate (-3.26 BW·s-1 [-5.94, -0.59], p = 0.02) indicated lower measure of loading in stable supportive shoes compared to flexible shoes. Conclusions Stable supportive shoes reduced MTCF during loading stance and reduced loading impulse/rates compared to flat flexible shoes and therefore may be more suitable in people with medial knee osteoarthritis and varus malalignment. Trial registration Australian and New Zealand Clinical Trials Registry (12619000622101).

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The compartmental distribution of knee osteoarthritis – a systematic review and meta-analysis

Cited by 86 publications

References 55 publications

Association between the inclination angle of the proximal tibiofibular joint surface and medial compartment knee osteoarthritis

Association between the inclination angle of the proximal tibiofibular joint surface and medial compartment knee osteoarthritis

Predicting Hip-Knee-Ankle and Femorotibial Angles from Knee Radiographs with Deep Learning

Tibiofemoral contact force differences between flat flexible and stable supportive walking shoes in people with varus-malaligned medial knee osteoarthritis: A randomized cross-over study

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