The COVID-19 pandemic has seen opponents of public health mandates deploy a range of populist and anti-elite arguments. The 2021 Canadian federal election was an exceptional “pandemic election” in which the COVID-19 health crisis took centre stage. But the election campaign also saw the populist People's Party of Canada (PPC) rise to prominence by opposing pandemic-related public health restrictions. While the party failed to win a seat, it did manage to triple its vote share (1.6 per cent to 4.9 per cent). It is unclear, however, what factors led to the rise in support for the PPC. To explore this issue, we draw on an original post-election survey (n = 18,950) and focus on populist attitudes and opposition to COVID-19-related public health restrictions. Results from regression models and structural equation models (SEMs) indicate that opposition to public health restrictions was a much stronger factor than populism in shaping support for the PPC.