The complex interaction between vitamin D, folate, and heavy metals: potential for attenuation of blood pressure effects

Islam, Sumaiya; Visaria, Aayush; Raju, P. Krishnam; James, Justin; Polamarasetti, Pooja

doi:10.1097/hjh.0000000000002840

Cited by 1 publication

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“…Besides its well-known role in calcium homeostasis, Vitamin D deficiency also contributes to CVD [ 13 ]. A new study revealed that the complicated relationship between vitamin D, folate, and heavy metals may be able to lessen the impact on blood pressure [ 14 ]. It is not known in the United States (U.S.) general population whether serum 25-hydroxyvitamin D (25(OH)D) levels are related to heavy metal exposure.…”

Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D mediates the association between heavy metal exposure and cardiovascular disease

Lu,

Zhang

et al. 2024

BMC Public Health

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Background Mediation analysis aims to determine how intermediate variables affect exposure to disease. In this study, 25-hydroxyvitamin D (25(OH)D) was evaluated to assess its role in mediating heavy metal exposure and cardiovascular disease (CVD). Methods A total of 9,377 participants from the National Health and Nutrition Examination Survey (NHANES) for the years 2011-2018 were included. Firstly, restricted cubic spline (RCS), and multivariable logistic regression model were performed to estimate the association between heavy metal exposure (Cadmium, Lead, Mercury, Manganese, and Selenium), as well as serum 25(OH)D and CVD. Secondly, using generalized linear regression model and generalized additive models with smooth functions, we investigated the correlation between heavy metal exposure and serum 25(OH)D. Finally, the mediation effect of serum 25(OH)D in the associations between heavy metal exposure and CVD was explored. Results The RCS plots revealed that Cadmium, and Lead were positively and linearly associated with CVD, while Mercury, and Manganese were inversely and linearly associated with CVD. Additionally, a roughly L- and U-shaped relationship existed between Selenium, as well as 25(OH)D and CVD. When potential confounding factors were adjusted for, serum 25(OH)D had negative associations with Cadmium, Lead, and Manganese, while serum 25(OH)D had positive relationship with Selenium. There was a mediation effect between Manganese exposure and CVD, which was mediated by 25(OH)D. Conclusion According to the mediation analysis, the negative association between Manganese exposure and incident CVD was increased by 25(OH)D. The increasing dietary intake of Vitamin D could increase the protective effect of manganese intake on CVD.

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Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D mediates the association between heavy metal exposure and cardiovascular disease

Lu,

Zhang

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

show abstract

The complex interaction between vitamin D, folate, and heavy metals: potential for attenuation of blood pressure effects

Abstract: consuming high sodium in their diets (>5 g/day of sodium) to moderate levels (3 to 5 g/day).

Cited by 1 publication

References 11 publications

Serum 25-hydroxyvitamin D mediates the association between heavy metal exposure and cardiovascular disease

Serum 25-hydroxyvitamin D mediates the association between heavy metal exposure and cardiovascular disease

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