The complex interplay between stress and bacterial infections in animals

Verbrugghe, Elin; Boyen, Filip; Gaastra, Wim; Bekhuis, Leonie; Leyman, Bregje; Parys, Alexander Van; Haesebrouck, Freddy; Pasmans, Frank

doi:10.1016/j.vetmic.2011.09.012

Cited by 120 publications

(74 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…July through September is considered summer, with an average temperature of 32°C, and the temperature does not fluctuate throughout the season. Heat stress can predispose the birds to infectious diseases requiring treatment (23). However, this would not explain the significant differences in the number of positive eggs during these months, because the temperature was consistently hot throughout the study.…”

Section: Resultsmentioning

confidence: 94%

Detection of Quinolones in Commercial Eggs Obtained from Farms in the Espaillat Province in the Dominican Republic

Moscoso¹,

Santos²,

Andino³

et al. 2015

Journal of Food Protection

View full text Add to dashboard Cite

Previously, we reported the use of quinolones in broiler chickens resulted in residues in retail poultry meat obtained from nine districts in the Santiago Province of the Dominican Republic. Residues in poultry products are a concern due to consumer allergies and the potential to develop antibiotic-resistant bacteria. Given the use of quinolones in poultry production and our previous findings in poultry meat, the objective of this study was to evaluate the presence of quinolone residues in eggs. Samples were collected from 48 different farms located in three of the four municipalities (Moca, Cayetano Germosén, and Jamao) of the Espaíllat Province. Each farm was sampled three times between July and September for a total of 144 samples. Samples were evaluated qualitatively and quantitatively for quinolone residues using the Equinox test. Operation systems (cage or floor), seasonality, and location were considered along with egg-producer sizes that were defined as small scale, <30,000 eggs per day; medium scale, 30,000 to 60,000 eggs per day; or large scale, >60,000 eggs per day. From small-, medium-, and large-scale producers, 69, 50, and 40% of samples were positive for quinolone residues, respectively. A greater number of samples were positive (61%) in floor-laying hen producers compared with those using cages (40%). In the Jamao municipality, 67% of the samples were positive compared with Moca and Cayetano Germosén, where 56 and 25% of samples were positive, respectively. Sampling time had an effect on percent positives: samples collected in July, August, and September were 71, 19, and 63% positive, respectively. Overall, 51% of the samples obtained from eggs produced in the province of Espaíllat were positive for quinolone residues at levels higher than the maximum limits for edible tissue established by the regulatory agencies, including the European Union and U.S. Department of Agriculture. The results obtained from this research confirmed the presence of quinolone residue in eggs, which may present a health risk to some consumers.

show abstract

Section: Resultsmentioning

confidence: 94%

Detection of Quinolones in Commercial Eggs Obtained from Farms in the Espaillat Province in the Dominican Republic

Moscoso¹,

Santos²,

Andino³

et al. 2015

Journal of Food Protection

View full text Add to dashboard Cite

show abstract

“…Pathogen targets heat-stressed corals M Garren et al bacterial infection of stressed animals (Mydlarz et al, 2006;Verbrugghe et al, 2012) suggests that chemical interactions such as these may be a recurring element in other marine diseases. The behavioral response of V. coralliilyticus to coral mucus and DMSP is not limited to chemotaxis, but includes a second, powerful behavioral adaptation: chemokinesis.…”

Section: Resultsmentioning

confidence: 99%

A bacterial pathogen uses dimethylsulfoniopropionate as a cue to target heat-stressed corals

et al. 2013

View full text Add to dashboard Cite

Diseases are an emerging threat to ocean ecosystems. Coral reefs, in particular, are experiencing a worldwide decline because of disease and bleaching, which have been exacerbated by rising seawater temperatures. Yet, the ecological mechanisms behind most coral diseases remain unidentified. Here, we demonstrate that a coral pathogen, Vibrio coralliilyticus, uses chemotaxis and chemokinesis to target the mucus of its coral host, Pocillopora damicornis. A primary driver of this response is the host metabolite dimethylsulfoniopropionate (DMSP), a key element in the global sulfur cycle and a potent foraging cue throughout the marine food web. Coral mucus is rich in DMSP, and we found that DMSP alone elicits chemotactic responses of comparable intensity to whole mucus. Furthermore, in heat-stressed coral fragments, DMSP concentrations increased fivefold and the pathogen's chemotactic response was correspondingly enhanced. Intriguingly, despite being a rich source of carbon and sulfur, DMSP is not metabolized by the pathogen, suggesting that it is used purely as an infochemical for host location. These results reveal a new role for DMSP in coral disease, demonstrate the importance of chemical signaling and swimming behavior in the recruitment of pathogens to corals and highlight the impact of increased seawater temperatures on disease pathways.

show abstract

“…Heat stress was linked to a decrease in immune activity in poultry and mammals, following invasion by pathogenic bacteria (such as Salmonella spp.) through the intestinal epithelium (Burkholder et al, 2008;Quinteiro-Filho et al, 2012a;Verbrugghe et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Overcrowding stress decreases macrophage activity and increasesSalmonellaEnteritidis invasion in broiler chickens

et al. 2014

View full text Add to dashboard Cite

Overcrowding stress is a reality in the poultry industry. Chickens exposed to long-term stressful situations present a reduction of welfare and immunosuppression. We designed this experiment to analyse the effects from overcrowding stress of 16 birds/m 2 on performance parameters, serum corticosterone levels, the relative weight of the bursa of Fabricius, plasma IgA and IgG levels, intestinal integrity, macrophage activity and experimental Salmonella Enteritidis invasion. The results of this study indicate that overcrowding stress decreased performance parameters, induced enteritis and decreased macrophage activity and the relative bursa weight in broiler chickens. When the chickens were similarly stressed and infected with Salmonella Enteritidis, there was an increase in feed conversion and a decrease in plasma IgG levels in the stressed and Salmonella-infected birds. We observed moderate enteritis throughout the duodenum of chickens stressed and infected with Salmonella. The overcrowding stress decreased the macrophage phagocytosis intensity and increased Salmonella Enteritidis counts in the livers of birds challenged with the pathogenic bacterium. Overcrowding stress via the hypothalamic-pituitary-adrenal axis that is associated with an increase in corticosterone and enteritis might influence the quality of the intestinal immune barrier and the integrity of the small intestine. This effect allowed pathogenic bacteria to migrate through the intestinal mucosa, resulting in inflammatory infiltration and decreased nutrient absorption. The data strengthen the hypothesis that control of the welfare of chickens and avoidance of stress from overcrowding in poultry production are relevant factors for the maintenance of intestinal integrity, performance and decreased susceptibility to Salmonella infection.

show abstract

The complex interplay between stress and bacterial infections in animals

Cited by 120 publications

References 144 publications

Detection of Quinolones in Commercial Eggs Obtained from Farms in the Espaillat Province in the Dominican Republic

Detection of Quinolones in Commercial Eggs Obtained from Farms in the Espaillat Province in the Dominican Republic

A bacterial pathogen uses dimethylsulfoniopropionate as a cue to target heat-stressed corals

Overcrowding stress decreases macrophage activity and increasesSalmonellaEnteritidis invasion in broiler chickens

Contact Info

Product

Resources

About