The Complex Network between Inflammation and Colorectal Cancer: A Systematic Review of the Literature

Percario, Rossana; Panaccio, Paolo; Mola, Fabio Francesco di; Grottola, Tommaso; Sebastiano, Pierluigi Di

doi:10.3390/cancers13246237

Cited by 16 publications

(12 citation statements)

References 62 publications

(137 reference statements)

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“…Colorectal cancer is a common gastrointestinal tumor ( 6 ). In 2012, colorectal cancer ranked third for incidence among men and second among women, with approximately 1.4 million new cases and about 690,000 deaths, making it the fourth most deadly cancer worldwide ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Systematic review and meta-analysis of the risk factors of surgical site infection in patients with colorectal cancer

Cai¹,

Wang²,

Wang³

et al. 2022

Transl Cancer Res TCR

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Background Surgical site infection (SSI) influenced the result of surgical treatment, which was known as the second most prevalent hospital-based infection. But, the factors of SSI are not uniform. The purpose of this study was to identify the risk factors of SSI in patients with colorectal cancer. We conducted a meta-analysis of epidemiological research to provide a scientific basis for the prevention of SSI. Methods The PubMed, Medline, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases were independently searched by 2 researchers to identify all relevant studies. Studies were selected if they met the selection criteria, which was defined according to the PICOS principles. The quality of the evidence was assessed using Egger’s P value, study heterogeneity, and sample size. Studies were categorized into 3 groups as follows: low quality (Class 4), moderate quality (Class 2/3), and high quality (Class 1). The meta-analysis was performed using RevMan 5.3 software. Results A total of 17 studies involving 61,611 patients were included in the meta-analysis. The results identified 7 patient-related risk factors of SSI, including male gender, obesity, diabetes mellitus, American Society of Anesthesiologists (ASA) score, cigarette smoking, tumor location, and serum albumin level, and 5 treatment-related risk factors, including laparoscopic surgery, operation time, blood loss, blood transfusion, and abdominal surgical history. Age was not directly related to SSI in colorectal cancer. Conclusions It is possible that patients can be treated effectively by identifying these factors of SSI.

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Section: Introductionmentioning

confidence: 99%

Systematic review and meta-analysis of the risk factors of surgical site infection in patients with colorectal cancer

Cai¹,

Wang²,

Wang³

et al. 2022

Transl Cancer Res TCR

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show abstract

“…In fact, it accounted for 10% of newly diagnosed cancer cases and 9.4% cancer-related deaths worldwide in 2020, making it the second most common cancer of the year. The CRC has complex causes, including factors such as genetics, diet, and inflammation. , Despite the increasing diversity of clinical approaches for the treatment of tumors, , the prognosis of patients with CRC remains unsatisfactory. Therefore, novel therapeutic approaches need to be developed urgently for improving the prognosis of patients with CRC …”

Section: Introductionmentioning

confidence: 99%

Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme

Xin

Zheng

et al. 2022

J. Agric. Food Chem.

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Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types. This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations. The fucoidan-induced anti-inflammatory effect was also confirmed through in vivo experiments in mice. Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention. In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis. It also blocked the cell cycle of DLD-1 and SW480 at the G0/G1 phase. The animal model of inflammation-related CRC showed that the incidence of tumors in mice was significantly reduced by fucoidan intervention. Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues. Therefore, fucoidan can effectively prevent the development of colitis-associated CRC.

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“…This imbalance in intestinal bacterial composition results in varying degrees of intestinal flora dysbiosis, which in turn increases permeability of the intestinal mucosa and levels of inflammatory factors. It is believed that these changes play a crucial role in the development and progression of CRC [ 28 ]. Probiotic supplementation can effectively regulate the composition of the intestinal flora and influence the development and treatment of CRC [ 12 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the differential expression of serum miR-21-5p, miR-135-5p, and miR-155-5p by Bifidobacterium triplex viable capsules during the perioperative stage of colorectal cancer

Zhang,

Guo,

et al. 2024

Int J Colorectal Dis

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Objective In this study, we investigated the impact of perioperative administration of Bifidobacterium triplex viable capsules on the serum levels of circulating miR-21-5p, miR-135-5p, and miR-155-5p in patients with colorectal cancer (CRC). The purpose of this study is to provide a foundation for future research on the use of Bifidobacterium triplex viable capsules to enhance postoperative recovery in patients with CRC. Methods A total of 60 patients with primary CRC admitted to the Department of General Surgery at Shanxi Bethune Hospital between June 2020 and December 2020 were selected and randomly divided into two groups: 20 cases in the control group and 40 cases in the experimental group. The experimental group was administered oral Bifidobacterium triplex viable capsules during the perioperative period, while the control group was administered oral placebo. Before and after the perioperative period, the expression levels of miR-21-5p, miR-135-5p, and miR-155-5p were compared in the serum of both groups of patients. Furthermore, we established the prognostic value of these three miRNAs in CRC patients. Results After surgery, the expression levels of miR-21-5p, miR-135-5p, and miR-155-5p decreased in both groups of patients (P < 0.05). Significantly greater differences were observed between miR-21-5p and miR-135-5p (P < 0.001). Expression levels of serum miR-21-5p (P = 0.020) and miR-135-5p (P = 0.023) decreased significantly more in the experimental group than in the control group. The levels of the above three miRNAs after surgery did not correlate with 3-year OS (HR = 4.21; 95% CI 0.37–47.48; log-rank P = 0.20) or 3-year DFS (HR = 1.57; 95% CI 0.32–7.66; log-rank P = 0.55) in two groups. Conclusion Radical surgery reduces the levels of serum miR-21-5p, miR-135-5p, and miR-155-5p expression in patients with CRC. The use of Bifidobacterium triplex viable capsules assists in achieving quicker perioperative recovery from radical surgery in CRC patients, and this underlying mechanism may be associated with the regulation of serum miR-21-5p, miR-135-5p, and miR-155-5p expression levels.

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The Complex Network between Inflammation and Colorectal Cancer: A Systematic Review of the Literature

Cited by 16 publications

References 62 publications

Systematic review and meta-analysis of the risk factors of surgical site infection in patients with colorectal cancer

Systematic review and meta-analysis of the risk factors of surgical site infection in patients with colorectal cancer

Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme

Analysis of the differential expression of serum miR-21-5p, miR-135-5p, and miR-155-5p by Bifidobacterium triplex viable capsules during the perioperative stage of colorectal cancer

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