The Complex Network between MYC Oncogene and microRNAs in Gastric Cancer: An Overview

Abstract

Despite the advancements in cancer treatments, gastric cancer is still one of the leading causes of death worldwide. In this context, it is of great interest to discover new and more effective ways of treating this disease. Accumulated evidences have demonstrated the amplification of 8q24.21 region in gastric tumors. Furthermore, this is the region where the widely known MYC oncogene and different microRNAs are located. MYC deregulation is key in tumorigenesis in various types of tissues, once it is associated with cell proliferation, survival, and drug resistance. microRNAs are a class of noncoding RNAs that negatively regulate the protein translation, and which deregulation is related with gastric cancer development. However, little is understood about the interactions between microRNAs and MYC. Here, we overview the MYC role and its relationship with the microRNAs network in gastric cancer aiming to identify potential targets useful to be used in clinic, not only as biomarkers, but also as molecules for development of promising therapies.

The Silkworm Carboxypeptidase Inhibitor Prevents Gastric Cancer Cells’ Proliferation through the EGF/EGFR Signaling Pathway

“…Aberrant expression of c-Myc leads to genomic instability and tumorigenesis and maintains tumor growth [ 48 ]. One study found that the mRNA and protein expression of c-Myc were increased in HGC-27 and SGC-7901 gastric cancer cell lines compared with the human gastric mucosal cell line GES-1, and knockdown of c-Myc expression inhibited gastric cancer cell proliferation [ 49 ]. Therefore, the silkworm carboxypeptidase inhibitor likely down-regulated the expression of c-Myc, leading to an inhibited proliferation of gastric cancer cells.…”

Effect of Electroacupuncture at Zusanli (ST36) on Intestinal Microbiota in Rats With Chronic Atrophic Gastritis

“…The Bcl-2 family, on the other hand, is part of the core mechanism of apoptosis, and the anti-apoptotic properties of Bcl-2 protect cells from various damaging factors ( Schenk et al, 2017 ). The myc gene family mainly comprises C-myc, N-myc, and L-myc—three highly related nuclear phosphorylated proteins, and the literature suggests that activation of the myc genes may affect cell function, inhibit apoptosis, promote abnormal cell proliferation, and lead to tumorigenesis through multiple pathways ( Ba et al, 2018 ; Tong-peng et al, 2019 ; Anauate et al, 2020 ). c-myc genes are indicators for the evaluation of the effect of the GC disease process and treatment, and therefore, they are the most frequently studied indicators in studies on GC ( Won et al, 2019 ).…”

Prognostic Value and Biological Functions of RNA Binding Proteins in Stomach Adenocarcinoma

“…As we all have known TF, MYC promotes the progression of STAD through regulating downstream genes and different pathways. 21 FOXM1 has also been testified to play a crucial role in the occurrence and chemoresistance of gastric cancer. 22 As the potential targets of TFs, RBPs and their roles in STAD deserve our further efforts.…”