The complex photochemistry of coumarin-3-carboxylic acid in acetonitrile and methanol

Yang, Qiuyun; Váňa, Jiří; Klán, Petr

doi:10.1007/s43630-022-00238-8

Cited by 3 publications

(2 citation statements)

References 80 publications

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“…According to current reports, combination therapy with two or more drug-action mechanisms notably improves the therapeutic efficacy and avoids recurrences caused by multidrug resistance. − Recently, singlet oxygen ( 1 O 2 ) has been widely used as an alternative to antibiotics. − It is a strong oxidant that oxidizes the proteins or lipids, leading to cell death. , Some chromophores, which act as PRPGs, can also act as photosensitizers, , leading to 1 O 2 generation upon light irradiation. We thought such molecules could help to treat the bacterial infection more effectively by using combination therapy.…”

Section: Introductionmentioning

confidence: 99%

“…25−27 It is a strong oxidant that oxidizes the proteins or lipids, leading to cell death. 28,29 Some chromophores, which act as PRPGs, can also act as photosensitizers, 30,31 leading to 1 O 2 generation upon light irradiation. We thought such molecules could help to treat the bacterial infection more effectively by using combination therapy.…”

Section: ■ Introductionmentioning

confidence: 99%

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β-Carboline-Norfloxacin Nanoconjugates as Antibacterial Nanophotocages for the Delivery of Norfloxacin and Singlet Oxygen

Sikder

Mondal

Rabiya

et al. 2022

ACS Appl. Nano Mater.

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Herein, we demonstrate the design and synthesis of a single-component prodrug [β-carboline-benzothiazole-norfloxacin (CB-NFX)] for the cocktail release of therapeutics that enables spatiotemporal control over bacterial growth. With the help of in silico studies, the prodrug was designed based on the β-carboline photoremovable protecting group, caging the acid functionality of norfloxacin (NFX) antibiotic. We have formulated nanoparticles of CB-NFX to obtain nanophotocage CB-NFX NPs. These nanoparticles adhere to the bacterial cell wall, followed by the release of NFX and singlet oxygen ( 1 O 2 ) upon visible-light irradiation. The combined effect of the therapeutics shows excellent spatiotemporal control in bacterial inhibition. This concept can be applied to develop other advanced antibacterial biomaterials for combination therapy (drug and 1 O 2 ) and find wide applications in antibacterial research.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

β-Carboline-Norfloxacin Nanoconjugates as Antibacterial Nanophotocages for the Delivery of Norfloxacin and Singlet Oxygen

Sikder

Mondal

Rabiya

et al. 2022

ACS Appl. Nano Mater.

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Photochemical and Photophysical Processes in Photochemotherapy, Search for New Drugs

Kuzmin,

Nekipelova,

Khodot

et al. 2024

High Energy Chem

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Фoтохимические и фотофизические процессы в фотохимиотерапии, поиск новых препаратов

Кузьмин,

Некипелова,

Ходот

et al. 2024

Himiâ vysokih ènergij

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В обзоре обобщены и систематизированы данные по строению, фотохимическим и фотофизическим свойствам фурокумаринов (псораленов) и их аналогов, представлены современные представления о роли триплетных состояний и реакции [2+2]-фотоциклоприсоединения при взаимодействии этих соединений с биомакромолекулами (ДНК, белками, липидами) после фотовозбуждения светом УФ-А диапазона (320–390 нм), а также реакции переноса электрона и взаимодействия триплетов фурокумаринов с кислородом c образованием активных форм кислорода. Взаимодействие триплетов фурокумаринов с биомакромолекулами является основой фотохимиотерапии (ПУВА-терапии). Использование в ПУВА-терапии фурокумаринов растительного происхождения выявило ряд нежелательных побочных явлений, поэтому в последние годы предпринимаются попытки синтеза новых соединений для фотохимиотерапии. В обзоре рассматриваются современные направления этих работ: это модифицированные псоралены, производные ангулярных фурокумаринов, ангелицина и аллопсоралена, и азотсодержащие изостеры псоралена, фурохинолиноны и фуродигидрохинолины.

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The complex photochemistry of coumarin-3-carboxylic acid in acetonitrile and methanol

Cited by 3 publications

References 80 publications

β-Carboline-Norfloxacin Nanoconjugates as Antibacterial Nanophotocages for the Delivery of Norfloxacin and Singlet Oxygen

β-Carboline-Norfloxacin Nanoconjugates as Antibacterial Nanophotocages for the Delivery of Norfloxacin and Singlet Oxygen

Photochemical and Photophysical Processes in Photochemotherapy, Search for New Drugs

Фoтохимические и фотофизические процессы в фотохимиотерапии, поиск новых препаратов

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