The complex repertoire of Tityus spp. venoms: Advances on their composition and pharmacological potential of their toxins

Wiezel, Gisele A.; Oliveira, Isadora S.; Reis, Mouzarllem B.; Ferreira, Isabela G.; Cordeiro, Kalynka R.; Bordon, Karla C.F.; Arantes, Eliane C.

doi:10.1016/j.biochi.2023.12.012

Biochimie

2024

DOI: 10.1016/j.biochi.2023.12.012

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The complex repertoire of Tityus spp. venoms: Advances on their composition and pharmacological potential of their toxins

Gisele A. Wiezel,

Isadora S. Oliveira,

Mouzarllem B. Reis

et al.

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2024

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Cited by 2 publications

References 167 publications

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Immunosuppressive therapies in scorpion envenomation: new perspectives for treatment

Reis,

Arantes

2024

Front. Toxicol.

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Scorpion envenoming is a relevant and neglected public health problem in some countries. The use of antivenom is widespread in many regions, targeting specific species of scorpions. However, the uncontrolled proliferation and adaptation of these animals to urban environments, combined with limited access to treatments in remote areas and delays in antivenom administration contribute to a significant number of fatalities from scorpion-related incidents. In recent decades, new research has revealed that the immune system plays an important role in triggering immunopathological reactions during scorpion envenoming, which places it as a therapeutic target; however, few clinical studies have been conducted. This work provides a review of the main immunopathological aspects of scorpion envenoming, as well as the clinical trials conducted to date on the use of corticosteroids for the treatment of scorpionism. We highlight emerging treatment perspectives as well as the need for further clinical trials. The use of corticosteroids in scorpionism, when appropriate, could significantly enhance access to treatment and help reduce fatalities associated with scorpion stings.

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Immunosuppressive therapies in scorpion envenomation: new perspectives for treatment

Reis,

Arantes

2024

Front. Toxicol.

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Therapeutic Potential of Solenopsis invicta Venom: A Scoping Review of Its Bioactive Molecules, Biological Aspects, and Health Applications

Dioguardi,

Cantore,

Sovereto

et al. 2024

Biomolecules

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Solenopsis invicta, a South American ant species from the Formicidae family (subfamily Myrmicinae), has recently established a stable settlement in Europe, raising public health concerns due to its venomous stings. The venom of S. invicta is rich in bioactive molecules, particularly piperidine alkaloids such as solenopsin A and peptides (Sol 1–4). These compounds have been implicated in various health applications, including antimicrobial, anti-inflammatory, and antitumour activities. While previous reviews have focused on the ecological and allergenic risks posed by S. invicta, this scoping review aims to evaluate the potential therapeutic uses of S. invicta venom by summarizing existing scientific evidence and providing a novel synthesis of recent research on its bioactive components. Furthermore, this study, by describing the unique biological aspects of S. invicta, provides an overview of its direct impact on public health, highlighting new findings on the venom’s role in inhibiting bacterial biofilm formation and modulating cancer growth pathways through gene regulation. A search of databases (PubMed, Scopus, Science Direct, and Cochrane Library) identified 12,340 articles, from which 11 studies met the eligibility criteria. These studies included seven microbiological investigations and four studies on tumour cell lines and animal models. The findings suggest that S. invicta venom could inhibit biofilm formation, combat fungal infections, and suppress tumour growth. However, further research, including clinical trials, is required to fully elucidate the safety and efficacy of these bioactive molecules in human medicine, for their potential use in drug discovery to counteract several diseases, including cancer.

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The complex repertoire of Tityus spp. venoms: Advances on their composition and pharmacological potential of their toxins

Cited by 2 publications

References 167 publications

Immunosuppressive therapies in scorpion envenomation: new perspectives for treatment

Immunosuppressive therapies in scorpion envenomation: new perspectives for treatment

Therapeutic Potential of Solenopsis invicta Venom: A Scoping Review of Its Bioactive Molecules, Biological Aspects, and Health Applications

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