The complexation of transition series metal ions by nalidixic acid

Cole, A.; Goodfield, J.; Williams, David R.; Midgley, John M.

doi:10.1016/s0020-1693(00)80004-3

Cited by 38 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The low activity observed against E. coli , especially at low concentrations, could be due to the presence of lipopolysaccharides in the outer membrane of the G−ve bacteria, which make them inherently resistant to external agents. Cole et al [ 36 ] have reported that the differences among G−ve and G+ve bacteria regarding the bactericidal effect are due to the structure of their cell walls, where the G−ve bacteria have a more complex cell wall composed of a thin peptidoglycan layer and an outer membrane containing lipopolysaccharides, whereas G+ve bacteria are protected by a wall predominantly composed by one type of macromolecule (pepidoglycan). The obtained results are in agreement with Sadeek et al [ 37 ] who concluded that there is a significant increase in antibacterial activity of metal complexes compared to uncomplexed ligand.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Spectroscopic, and Biological Studies of Mixed Ligand Complexes of Gemifloxacin and Glycine with Zn(II), Sn(II), and Ce(III)

et al. 2018

View full text Add to dashboard Cite

Three novel mixed ligand metal complexes have been synthesized by the reaction of Zn(II), Sn(II), and Ce(III) with gemifloxacin (GMFX) in the presence of glycine (Gly) (1:1:1 molar ratio). The coordination possibility of the two ligands toward metal ions has been proposed in the light of elemental analysis, molar conductance, spectral infrared (IR), ultraviolet-visible (UV-Vis) and proton-nuclear magnetic resonance (1H NMR), and magnetic studies. Results suggest that GMFX and Gly interact with the metal ions as bidentate ligands. Electronic and magnetic data proposed the octahedral structure for all complexes under investigation. Antibacterial screening of the compounds was carried out in vitro against two Gram-positive bacteria, Clavibacter michiganensis and Bacillus megaterium, and two Gram-negative bacteria, Escherichia coli and Xanthomonas campestris. Antifungal activity was performed in vitro against Rhizoctonia solani, Sclerotinia sclerotiorum, Aspergillus niger, Botrytis cinerea, and Penicillium digitatum. The ligands and their complexes were also screened for their antioxidant activity. Results showed that some metal complexes showed more biological efficiency than the parent GMFX drug.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis, Spectroscopic, and Biological Studies of Mixed Ligand Complexes of Gemifloxacin and Glycine with Zn(II), Sn(II), and Ce(III)

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It is well known that the absorption of quinolones appears to be significantly reduced in the presence of various metal ions. The reason is probably the chelation between the quinolone and the metal ion (Cole et al, 1984;Polk, 1989; Kara et al, 1991). O O…”

Section: Introductionmentioning

confidence: 99%

NMR Investigation of the Copper(II)‐Ciprofloxacin System

et al. 1998

View full text Add to dashboard Cite

A proton NMR study was performed on the copper(ll)-ciprofloxacin system. The proton relaxation times (T1) were determined from the titration data in acidic and basic media. In acidic medium the H5 signal is dramatically affected and it is assumed that copper is bonded to the quinolone through carbonyl and one of the carboxyl oxygens. Such bonding is in agreement with the X-ray literature data for the complex [Cu(cf)1]Cl2.6H2O isolated from the slightly acidic solution. There are additional significant changes in 1T1 of H3′ and H5′ atoms which suggest that the terminal nitrogen atom of the piperazine ring system-N4′ also interacts with copper in the basic conditions. Thus it is plausible that more than one species are present in the solution at high pH values.

show abstract

“…[2] Metal ions play a vital role in a vast number of widely differing biological processes and depending on their concentration, they may either contribute towards the health of the organism or cause toxicity. [3][4][5][6] Several metal chelates are known to possess antibacterial, antifungicidal, antiviral and anticancer activity. In several cases, the metal chelates have been found to be more antimicrobial than the chelating agents themselves.…”

Section: Introductionmentioning

confidence: 99%

Biological activities of some Fluoroquinolones-metal complexes

Akinremi¹,

Obaleye²,

Amolegbe³

et al. 2012

Int J Med Biomed Res

View full text Add to dashboard Cite

Background: Metal ions play a vital role in the design of more biologically active drugs. Aim: The paper reviewed the antimicrobial, toxicological and DNA cleavage studies of some synthesized metal complexes of fluoroquinolone antibiotics. and Methods: Literature searches were done using scientific databases. Results: Computer search was used to reveal relevant studies. Spectrophotometric and X-ray analyses of the metal complexes have revealed the bi-dentate coordination of fluoroquinolone ligand to the metal through the ring carbonyl and one of the carboxylic oxygen atoms. Most of the metal complexes showed comparable activities and in some cases greater activity against tested organisms. On the toxicological tests carried out, some of the metal complexes had less adverse effect on the body tissues studied compared to the parent drugs. The DNA cleavage studies revealed the possibility of the metal-fluoroquinolone complexes destabilizing linear double stranded DNA. Conclusion: The reviewed metal complexes of fluoroquinolones have the potential of being used as drugs.

show abstract

The complexation of transition series metal ions by nalidixic acid

Cited by 38 publications

References 28 publications

Synthesis, Spectroscopic, and Biological Studies of Mixed Ligand Complexes of Gemifloxacin and Glycine with Zn(II), Sn(II), and Ce(III)

Synthesis, Spectroscopic, and Biological Studies of Mixed Ligand Complexes of Gemifloxacin and Glycine with Zn(II), Sn(II), and Ce(III)

NMR Investigation of the Copper(II)‐Ciprofloxacin System

Biological activities of some Fluoroquinolones-metal complexes

Contact Info

Product

Resources

About