2012
DOI: 10.1007/s11920-012-0330-7
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The Complexities of Depression

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Cited by 7 publications
(5 citation statements)
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“…In Australia, depression prevalence was 10% in 2017, with women recording higher rates (12%) than men (9%; Australian Bureau of Statistics, 2019). Depression is a multifactorial and complex disorder, and research proposes that a wide variety of factors could influence its heterogeneous and complex nature (Strakowski, 2012). Some biological factors include decreased monoamine function, dysfunctional hypothalamic pituitary adrenal (HPA) axis, neuro‐progression/brain plasticity, mitochondrial disturbances (Lopresti et al, 2013; Pereira et al, 2020), cytokine‐mediated inflammatory processes, increased oxidative stress, immune responses (Berk et al, 2013), immuno‐inflammation, gut dysbiosis and gut/brain relationship (Kaplan et al, 2015; Pereira et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…In Australia, depression prevalence was 10% in 2017, with women recording higher rates (12%) than men (9%; Australian Bureau of Statistics, 2019). Depression is a multifactorial and complex disorder, and research proposes that a wide variety of factors could influence its heterogeneous and complex nature (Strakowski, 2012). Some biological factors include decreased monoamine function, dysfunctional hypothalamic pituitary adrenal (HPA) axis, neuro‐progression/brain plasticity, mitochondrial disturbances (Lopresti et al, 2013; Pereira et al, 2020), cytokine‐mediated inflammatory processes, increased oxidative stress, immune responses (Berk et al, 2013), immuno‐inflammation, gut dysbiosis and gut/brain relationship (Kaplan et al, 2015; Pereira et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…Granted that those from lower SES backgrounds tend to exhibit anxiety and depressive symptoms more often than those from higher SES backgrounds, programmatic research on individuals in high-achieving settings—most of who are relatively affluent—suggests that a simple “more is better” model may not capture the complex manner in which SES is implicated in internalizing mental health problems (for a review, see Luthar et al, 2020). A more nuanced model that recognizes the complex association between access to resources and human motivational dispositions may be better suited to unpack complex mental health problems such as depression or anxiety (Coley, Spielvogel, & Sims, 2018; National Academies of Sciences, Engineering, and Medicine, 2019; Strakowski, 2012; Twenge et al, 2019). Therefore, a “better near the middle” model of SES may perhaps be more accurate than a “more is better” model for some outcomes, yet the “better near the middle” model remains understudied.…”
Section: Socioeconomic Status and Depressive Symptomsmentioning
confidence: 99%
“…As an example, when evaluating a patient with a mental health complaint, PAs should reflect on whether the same diagnosis would be considered if the patient were of a different race. Studies show that compared with White patients with similar presentations, patients of color are more likely to be diagnosed with schizophrenia than severe depression or bipolar disorder 47,48. Racism can further be addressed in numerous small interactions with staff, colleagues, and patients throughout the day by taking a vocal stand whenever biased statements or assumptions are witnessed 43,49.…”
Section: Recommendationsmentioning
confidence: 99%
“…Studies show that compared with White patients with similar presentations, patients of color are more likely to be diagnosed with schizophrenia than severe depression or bipolar disorder. 47,48 Racism can further be addressed in numerous small interactions with staff, colleagues, and patients throughout the day by taking a vocal stand whenever biased statements or assumptions are witnessed. 43,49 Although taking a stand may generate angst or discomfort, the point is to call attention to the implied discord.…”
Section: Recommendationsmentioning
confidence: 99%