The Complexity of Age-Related Hearing Impairment: Contributing Environmental and Genetic Factors

Eyken, Els Van; Camp, Guy Van; Laer, Lut Van

doi:10.1159/000106478

Cited by 262 publications

(214 citation statements)

References 259 publications

Supporting

Mentioning

206

Contrasting

Unclassified

Order By: Relevance

“…8 In addition, several association studies based on a candidate gene approach and two genome-wide association studies (GWAS) 8,9 have been conducted. Early candidate gene-based association studies are reviewed by Van Eyken et al 10 Recently, based on a candidate gene approach, we reported associations between ARHI and variants in GRHL2, 11 encoding a transcription factor that is also involved in monogenic hearing loss. In addition, based on a pooling GWAS, we reported association with variants in the glutamate receptor-7 gene (GRM7), 9 encoding a metabotropic glutamate receptor assumed to modulate hair cell excitability and synaptic efficacy.…”

Section: Introductionmentioning

confidence: 84%

A genome-wide association study for age-related hearing impairment in the Saami

et al. 2010

View full text Add to dashboard Cite

This study aimed at contributing to the elucidation of the genetic basis of age-related hearing impairment (ARHI), a common multifactorial disease with an important genetic contribution as demonstrated by heritability studies. We conducted a genomewide association study (GWAS) in the Finnish Saami, a small, ancient, genetically isolated population without evidence of demographic expansion. The choice of this study population was motivated by its anticipated higher extent of LD, potentially offering a substantial power advantage for association mapping. DNA samples and audiometric measurements were collected from 352 Finnish Saami individuals, aged between 50 and 75 years. To reduce the burden of multiple testing, we applied principal component (PC) analysis to the multivariate audiometric phenotype. The first three PCs captured 80% of the variation in hearing thresholds, while maintaining biologically important audiometric features. All subjects were genotyped with the Affymetrix 100 K chip. To account for multiple levels of relatedness among subjects, as well as for population stratification, association testing was performed using a mixed model. We summarised the top-ranking association signals for the three traits under study. The top-ranked SNP, rs457717 (P-value 3.55Â10 À7 ), was associated with PC3 and was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2). Intriguingly, the SNP rs161927 (P-value 0.000149), seventhranked for PC1, was positioned immediately downstream from the metabotropic glutamate receptor-7 gene (GRM7). As a previous GWAS of a European and Finnish sample set already suggested a role for GRM7 in ARHI, this study provides further evidence for the involvement of this gene.

show abstract

Section: Introductionmentioning

confidence: 84%

A genome-wide association study for age-related hearing impairment in the Saami

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Diese sensorineurale symmetrische Altersschwerhörigkeit ist deutlich im Hochtonfrequenzbereich ausgeprägt [5,12]. Die altersbedingte Hörminderung kann entweder auf lebenslange exogene und endogene Einflüsse sowie auf genetische Faktoren zurückzuführen sein [7,13,14]. Die Lärmexposition (Intensität und Dauer des Lärms) tritt in der Literatur als prädisponierender exogener Risikofaktor auf [5].…”

Section: Hintergrundunclassified

“…Die Lärmexposition (Intensität und Dauer des Lärms) tritt in der Literatur als prädisponierender exogener Risikofaktor auf [5]. Zu den negativen Einflüssen zählen zudem Ototoxine (ohrschädigende Substanzen), Rauchen [12], Infektionen, Schlaganfall [6,14], Hypertonie, Herz-Kreislauf-Erkrankungen, Diabetes und Durchblutungsstörungen [7,13]. Das Potenzial der Komorbiditäten als Risikofaktoren für Altersschwerhö-rigkeit wird in der Forschung kontrovers diskutiert.…”

Section: Hintergrundunclassified

Wahrnehmung von Hörproblemen bei älteren Menschen

Moser

Luxenberger

Freidl

2017

HNO

View full text Add to dashboard Cite

“…The onset of presbyacusis is not consistent among individuals. There are many factors which hasten the onset of presbyacusislike nutrition, lifestyle, environment [4] and occupational hazards, infection and illness, drug intake, hereditary etc.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ageing on Otoacoustic Emission

Murthy¹,

Kalyan²

2011

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

To study the effects of ageing on otoacoustic emission (OAE) in individuals with normal pure tone audiogram (PTA). Tertiary/Medical College Hospital. Descriptive/Prospective study. We screened healthy individuals: (1) (1) The individuals in the age group of 20-25 years showed absent/ decreased distortion product OAE (DPOAE) in two cases (2/50) with normal PTA. (2) The individuals in the age group of 45-50 years showed absent/decreased DPOAE in eleven cases (11/50) with normal PTA. (3) The individuals in the age group of 55-60 years showed absent/decreased DPOAE in 47 cases (47/50) with normal PTA. Just like any other organ in the body which exhibits the process of ageing, the cochlea too undergoes similar changes to the ageing process. The DPOAE is the first sign to disappear in presbyacusis. The many factors which hasten the onset of presbyacusis-like nutrition, lifestyle, environment and occupational hazards, infection and illness, drug intake, hereditary etc.; can be modified for prolonging a healthy natural hearing.

show abstract

The Complexity of Age-Related Hearing Impairment: Contributing Environmental and Genetic Factors

Cited by 262 publications

References 259 publications

A genome-wide association study for age-related hearing impairment in the Saami

A genome-wide association study for age-related hearing impairment in the Saami

Wahrnehmung von Hörproblemen bei älteren Menschen

Effects of Ageing on Otoacoustic Emission

Contact Info

Product

Resources

About