The complexity of inflammatory activity in caregivers: Commentary on “Associations of perceived stress, depressive symptoms, and caregiving with inflammation: A longitudinal study” by Elayoubi <i>et al</i>.

D’cruz, Migita

doi:10.1017/s1041610222001120

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…They also experience low-grade, nonspecific inflammation. This increase in inflammation is likely due to decreased anti-inflammatory feedback [13]. When the immunological response is no longer necessary, the HPA axis acts as a negative feedback mechanism to dampen it.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Allostatic Load With Immune, Inflammatory, and Coagulation Systems

Hassanpour

2023

Immunoregulation

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Dysregulation of the immune system, as well as the endocrine, metabolic, and coagulation systems, has been linked to stress. The type of stressor (acute or chronic) may have a differential effect on immune function, with brief acute stress enhancing some parameters of immunity and chronic stress having a negative effect on many parameters of immune function. The hypothalamic-pituitary-adrenal axis and autonomic (sympathetic and parasympathetic) nervous systems mediate stress and immune functions. Exposure to frequent stressors can lead to repeated physiological arousal, failure to adapt to repeated stressors, failure to terminate the stress response after the stressor has ceased, and inadequate allostatic load to the stressor. The allostatic load provides an overall and body system-specific mechanistic relationship between stressor exposures and health outcomes that may explain minority health disparities. Multiple physiological systems interact at differing levels of activity in this condition. Principally, the severity of allostatic load is determined by using biomarkers of numerous body systems that depict physiological disturbances. There is a substantial connection between stress, immune function, inflammation, and coagulation. Consequently, immune/inflammatory/coagulation biomarkers may play crucial roles in the calculation of allostatic load, and the recommendation of additional biomarkers may improve the estimation accuracy of allostatic load.

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Section: Introductionmentioning

confidence: 99%

Interaction of Allostatic Load With Immune, Inflammatory, and Coagulation Systems

Hassanpour

2023

Immunoregulation

View full text Add to dashboard Cite

show abstract

The complexity of inflammatory activity in caregivers: Commentary on “Associations of perceived stress, depressive symptoms, and caregiving with inflammation: A longitudinal study” by Elayoubi et al.

Cited by 1 publication

References 13 publications

Interaction of Allostatic Load With Immune, Inflammatory, and Coagulation Systems

Interaction of Allostatic Load With Immune, Inflammatory, and Coagulation Systems

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