The Complexity of Pulmonary Hypertension and Its Prognostic Importance in Patients With Valvular Heart Disease

Tempe, Deepak K

doi:10.1053/j.jvca.2018.09.034

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Many clinical studies have confirmed that the persistence of PAH after valve replacement is common, and PAH remains an important factor leading to a poor postoperative prognosis [ 3 – 5 ]. In clinical practice, the patients’ symptoms and quality of life may not improve significantly after surgery due to the presence of PAH, not only affecting the postoperative recovery of patients but also leading to the worsening of the disease [ 6 , 7 ]. In addition to routine treatment with cardiotonic drugs, diuresis and vasodilators, the use of targeted drugs is also gradually increasing.…”

Section: Introductionmentioning

confidence: 99%

Midterm postoperative prognosis of patients with severe left heart valvular disease combined with moderate or severe pulmonary hypertension treated with treprostinil

Huang

Kim

et al. 2020

BMC Cardiovasc Disord

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Background To investigate the midterm postoperative prognosis of patients with severe left heart valvular disease combined with moderate or severe pulmonary hypertension (PAH) using subcutaneous injection of treprostinil. Methods A retrospective study was conducted on 61 patients with severe left heart valvular disease combined with moderate or severe PAH who had undergone mechanical mitral and/or aortic valve replacement from April 2018 to October 2018. The patients were divided into the treprostinil group and the conventional treatment group according to whether they received treprostinil. The patients were assessed by SwanGanz catheterization, echocardiography, the 6-min walk test (6-MWT), the Borg dyspnoea score and the SF-36 questionnaire. Results Compared with the preoperative data, the mPAP measured by SwanGanz catheterization, the results of the 6-MWT and the Borg score were significantly improved in both groups during the 1 year follow-up (P < 0.05). Regarding the comparison between the groups, the results in group T were significantly better than those in group C, including the results of the 6-MWT and the general health, vitality and mental health of SF-36 during the 1 year follow-up (P < 0.05). Conclusions Continuous subcutaneous infusion of treprostinil was not capable of decreasing pulmonary pressures in patients with severe left heart valvular disease combined with moderate or severe PAH during 1 year follow-up, although which some of our data suggest that might improve the symptoms and quality of life of these patients.

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Section: Introductionmentioning

confidence: 99%

Midterm postoperative prognosis of patients with severe left heart valvular disease combined with moderate or severe pulmonary hypertension treated with treprostinil

Huang

Kim

et al. 2020

BMC Cardiovasc Disord

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“…39 40 The complexity of PH in valvular heart disease has been explained. 41 Fortunately, the PH following rheumatic mitral valve disease is of post-capillary type and resolves soon after surgery in most patients 42 43 with expected good outcome. Indeed, it has been shown that the mortality in mitral valve surgery is unaffected by severe PH (systolic PA pressure 50-79 mm Hg).…”

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confidence: 99%

Cardiac Anesthesiologist and Global Capacity Building to Tackle Rheumatic Heart Disease

Tempe

2021

Journal of Cardiothoracic and Vascular Anesthesia

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The Complexity of Pulmonary Hypertension and Its Prognostic Importance in Patients With Valvular Heart Disease

Cited by 2 publications

References 24 publications

Midterm postoperative prognosis of patients with severe left heart valvular disease combined with moderate or severe pulmonary hypertension treated with treprostinil

Midterm postoperative prognosis of patients with severe left heart valvular disease combined with moderate or severe pulmonary hypertension treated with treprostinil

Cardiac Anesthesiologist and Global Capacity Building to Tackle Rheumatic Heart Disease

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