The components and amylase activity of Massa Medicata Fermentata during the process of fermentation

Xu, Mingshu; Fu, Qiang; Baxter, A.

doi:10.1016/j.tifs.2019.07.027

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…The hot extract was added to the above well‐mixed powder and knead it into coarse granules, so that it can be formed into a ball by hand and scattered by throwing it. Put them into a mold and place it in a constant temperature and humidity oven at 30–37 °C and 70–85 % humidity [35] . The wrapped blocks are arranged in the shape of “pin”, and piled loosely, neatly, straight to increase the gap, which is conducive to heat dissipation and mold growth and reproduction.…”

Section: Methodsmentioning

confidence: 99%

Processing Mechanism of Massa Medicata Fermentata Based on the Correlation Analysis of Strains, Chemical Compositions and Anti‐Inflammatory Activity

Liu

Fan

et al. 2023

Chemistry & Biodiversity

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The traditional Chinese medicine of fermented medicine may be under the involvement of multiple strains and the interaction between these microorganisms. Liu Shenqu (Massa Medicata Fermentata, MMF) is one of the most widely used fermented medicines, whose potential processing mechanism is still unclear. In this work, UPLC/MS and GNPS methods were employed to rapidly predict chemical compositions in MMF. Moreover, the dynamic changes of strains, chemical compositions and anti-inflammatory activity of MMF during fermentation process were investigated, and subsequently strains-chemical compositions-efficacy interactions were revealed by Pearson correlation analysis and partial least squares regression (PLSR) analysis. As a result, 24 components were identified, and the potential strains including Bacillus, Burkholderia_Caballeronia_Paraburkholderia, Enterobacter, Aspergillus heterocaryoticus, Rhizopus arrhizus, Kazachstania bulderi, which related to the production of anti-inflammatory active ingredients were exposed. These results demonstrated chemical compositions-strainsefficacy interactions during fermentation of MMF, and provide reference for the exploration of the processing mechanism of MMF.

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Section: Methodsmentioning

confidence: 99%

Processing Mechanism of Massa Medicata Fermentata Based on the Correlation Analysis of Strains, Chemical Compositions and Anti‐Inflammatory Activity

Liu

Fan

et al. 2023

Chemistry & Biodiversity

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Section: Introductionmentioning

confidence: 99%

“…ex Roxb., Polygonum hydropiper L., Xanthium strumarium L., red bean, Armeniacae Amarum Semen, wheat flour, and wheat bran, which is fermented at a specific temperature and moisture level . MMF can ameliorate the symptoms of dyspepsia by regulating the homeostasis of the brain–gut–microbiota axis, treating gastrointestinal inflammation, and improving intestinal microflora disturbances. − Digestive enzymes and lactic acids in MMF are considered to be bioactive constituents of MMF with only a few studies focusing on the function of polysaccharides in MMF . In recent decades, natural polysaccharides in Chinese herbs have received considerable attention because of their promising health-promoting functions, such as anti-tumor, anti-inflammatory, antioxidant, anti-diabetic, radiation-protecting, antiviral, hypolipidemic, and immunomodulatory activities .…”

Section: Introductionmentioning

confidence: 99%

“…Massa Medicata Fermentata (MMF), also called Liu Shen Qu in Chinese, is a famous traditional Chinese medicine first recorded in the Treatise on Chinese Herbal Nature (Yaoxing Lun). 1 MMF consists of Artemisia caruifolia Buch.-Ham. ex Roxb., Polygonum hydropiper L., Xanthium strumarium L., red bean, Armeniacae Amarum Semen, wheat flour, and wheat bran, which is fermented at a specific temperature and moisture level.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Physicochemical and Bioactive Properties of Polysaccharides from Massa Medicata Fermentata and Its Processed Products

et al. 2022

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Two polysaccharides were separately extracted and purified from different types of medicinal slices of Massa Medicata Fermentata (Sheng Massa Medicata Fermentata and Chao Massa Medicata Fermentata). The physicochemical properties of these polysaccharides were studied, including the molecular weight, monosaccharide composition, and glycosidic linkage. Moreover, inhibition of trypsin, α-amylase, and α-glucosidase by the polysaccharides and their antioxidant activity were investigated. Compared with polysaccharides from Sheng Massa Medicata Fermentata, polysaccharides from Chao Massa Medicata Fermentata had a lower molecular weight, higher uronic acid content, and a lower proportion of side chains. Polysaccharides from Sheng Massa Medicata Fermentata displayed stronger trypsin, α-amylase, and α-glucosidase inhibition activity, whereas the antioxidant activity of the polysaccharides from Chao Massa Medicata Fermentata was higher. These results indicated that stir-frying changes the physicochemical properties of the polysaccharides significantly, leading to reduced enzyme inhibition activity and an increase in antioxidant activity. This research provides a guide for the selective application of Massa Medicata Fermentata.

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“…Several studies have revealed that MMF has digestive enzyme activities such as those of α-amylase, protease, and lipase [5,6]. As these enzymes support the endogenous digestive enzymes in saliva, gastric juice, and pancreatic juice [7], they are thought to contribute to the medicinal effects of MMF.…”

Section: Introductionmentioning

confidence: 99%

Effects of microbial fermentation on enzyme activity and volatile properties ofMassa Medicata Fermentata

Wang

Okutsu

Yoshizaki

et al. 2021

Traditional & Kampo Medicine

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Aim Massa Medicata Fementata (MMF) is a crude drug used in East Asia to treat anorexia and dyspepsia. It is prepared from wheat and several herbs through microbial fermentation using Aspergillus sp. and Rhizopus sp. There is great difference in the quality of commercial MMF, and the microbes of MMF are suggested to affect its quality. We investigated the effects of microbial fermentation on the quality of MMF. Methods Raw materials of MMF were mixed according to the ratio listed in the National Standard for Chinese Patent Drugs, and MMF was prepared using pure cultures of Aspergillus oryzae or Rhizopus oryzae. Digestive enzyme activities (α‐amylase, protease, and lipase) and volatile compounds were measured using an analytical kit and GC–MS, respectively. Results Enzyme activity increased in MMF. MMF prepared with A. oryzae (MMF‐A) showed higher α‐amylase and lipase activities than that prepared with R. oryzae (MMF‐R). Protease activity was marginally higher in MMF‐R than in MMF‐A. GC–MS analysis revealed that terpenoids decreased with fermentation; however, 2,3‐butanediol, acetoin, and guaiacol were detected in MMF only. C8 compounds such as 1‐octen‐3‐ol were higher in MMF‐A than MMF‐R; however, aromatic compounds such as 4‐vinylguaiacol and pyrazines were higher in MMF‐R than MMF‐A. Conclusion Microbial fermentation contributes to increased enzyme activity and changes in MMF volatiles. These properties of MMF were considerably affected by the microbes used, and it is proposed in this study that it is important to have microbial control in the production of commercial MMF.

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The components and amylase activity of Massa Medicata Fermentata during the process of fermentation

Cited by 10 publications

References 21 publications

Processing Mechanism of Massa Medicata Fermentata Based on the Correlation Analysis of Strains, Chemical Compositions and Anti‐Inflammatory Activity

Processing Mechanism of Massa Medicata Fermentata Based on the Correlation Analysis of Strains, Chemical Compositions and Anti‐Inflammatory Activity

Comparison of Physicochemical and Bioactive Properties of Polysaccharides from Massa Medicata Fermentata and Its Processed Products

Effects of microbial fermentation on enzyme activity and volatile properties ofMassa Medicata Fermentata

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