The Composition Alteration of Respiratory Microbiota in Lung Cancer

Zheng, Xi; Sun, Xiaochi; Liu, Qinye; Huang, Yue; Yuan, Yong

doi:10.1080/07357907.2020.1732405

Cited by 12 publications

(13 citation statements)

References 60 publications

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“…A significant role for microbiota is also recognized in lung cancer (LC), another smoking-related lung disease [ 8 , 9 , 10 ]. Evaluation of cancer tissue and/or tumor free tissue in LC patients showed characteristic patterns of microbiota including a shift to Proteobacteria, Actinobacteria [ 9 , 11 ] and/or Firmicutes [ 8 , 11 ]. Differences in microbiota composition may be due to different cancer subtypes; a decreased alpha diversity was found in tumor samples from squamous cell carcinoma [ 9 ], and specific communities with links to LC subtypes were observed with Acinetobacter , Brevundimonas and Propionibacteria in adenocarcinoma and Enterobacteriaceae in squamous cell carcinoma [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer

et al. 2020

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Human airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in upper airway, lower airway and lung tissue samples using 16S rDNA analysis. Bacterial density decreased stepwise from upper to lower airways and tissue. On a taxonomic level upper and lower airway microbiota were similar whereas lung tissue showed marked dissimilarities compared to lower airways that may reflect different environmental conditions shaping local microbiota and host immunity.

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Section: Introductionmentioning

confidence: 99%

Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer

et al. 2020

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“…For example, the relative abundance of the genera Neisseria and Porphyromonas is lower both in the duodenal luminal microbiome of our CS group and in the respiratory microbiome of smokers 46 . Genus Prevotella , which is highly abundant in the respiratory microbiome 46 , was lower in the CS group and is also noted to be decreased in the respiratory microbiome of lung cancer patients 16 and the fecal microbiome of tuberculosis patients 47 . Lastly, we identified higher relative abundance of Enterobacteriaceae and an Escherichia-Shigella species (likely E. coli ) in the duodenal luminal microbiome of our CS group, both of which are also higher in the gut microbiota of mice with respiratory influenza infections 48 .…”

Section: Discussionmentioning

confidence: 92%

“…Clinical studies of respiratory tract microbiota in smoking-related conditions such as lung cancer have shown variable results, likely due to significant differences in the microbiota of the upper and lower respiratory tract 15 , as well as differences in sampling and sequencing techniques among studies. However, a recent meta-analysis suggests increased abundances of the phyla Actinobacteria and Firmicutes in the respiratory microbiota of lung cancer patients, including lower relative abundance of the genus Prevotella , and higher Streptococcus , when compared to healthy controls 16 . Studies in mice have also shown that exposure to cigarette smoke significantly alters murine respiratory microbiota, with decreases in the genera Lactobacillus , Kluyvera, and Nesterenkonia and increases in Trichococcus and Escherichia-Shigella 17 , 18 .…”

Section: Introductionmentioning

confidence: 96%

Smoking has disruptive effects on the small bowel luminal microbiome

Leite¹,

Hosseini²,

Parodi³

et al. 2022

Sci Rep

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Tobacco use is the leading preventable cause of cancer, and affects the respiratory, oral, fecal, and duodenal mucosa-associated microbiota. However, the effects of smoking on the duodenal luminal microbiome have not been studied directly. We aimed to compare the duodenal luminal microbiome in never-smokers, current smokers, and ex-smokers who quit ≥ 10 years ago. In a cross-sectional study, current smokers (CS, n = 24) were identified and matched to never-smokers (NS, n = 27) and ex-smokers (XS, n = 27) by age (± 5 years), body mass index (BMI, ± 3 kg/m2), and sex. Current antibiotic users were excluded. The duodenal luminal microbiome was analysed in 1 aspirate sample per subject by 16S rRNA gene sequencing. Relative abundances (RA) of families associated with increased duodenal microbial diversity, Prevotellaceae, Neisseriaceae, and Porphyromonadaceae, were significantly lower in CS vs. NS. This was driven by lower RA of unknown Prevotella and Porphyromonas species, and Neisseria subflava and N. cinerea, in CS. In contrast, RA of Enterobacteriaceae and Lactobacillaceae (associated with decreased diversity), were significantly higher in CS, due to higher RA of Escherichia-Shigella, Klebsiella and Lactobacillus species. Many of these changes were absent or less pronounced in XS, who exhibited a duodenal luminal microbiome more similar to NS. RA of taxa previously found to be increased in the oral and respiratory microbiota of smokers were also higher in the duodenal luminal microbiome, including Bulledia extructa and an unknown Filifactor species. In conclusion, smoking is associated with an altered duodenal luminal microbiome. However, ex-smokers have a duodenal luminal microbiome that is similar to never-smokers.

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“…The results showed that CLP treatment could increase the levels of ACE, Chao1, and Shannon but could reduce the Simpson level, indicating that CLP improved lung dysbiosis through increasing microbiota diversity. On other hand, it has been known that the lower airways of patients with lung cancer were enriched with oral pathogenic bacteria Veillonella, Prevotella, and Streptococcus [54][55][56][57]. Interestingly, CLP not only decreased the abundance of those oral pathogenic commensals in the lung tissues of tumor-bearing mice but also directly inhibited the growth of S. pyogenes and S aureus, which are common lung pathogenic bacteria in patients with lung cancer [58,59], indicating its antimicrobial potential on tumor-related dysbiosis.…”

Section: Discussionmentioning

confidence: 99%

Polyacetylenes from Codonopsis lanceolata Root Induced Apoptosis of Human Lung Adenocarcinoma Cells and Improved Lung Dysbiosis

Wang

et al. 2022

BioMed Research International

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Codonopsis lanceolata is a perennial smelly herbaceous plant and widely employed for the treatment of various lung cancer and inflammation. However, the anticancer substances in C. lanceolata and their underlying mechanisms had not been well clarified. In this study, six compounds were obtained from the water extracts of C. lanceolata polyacetylenes (CLP) and then identified as syringin, codonopilodiynoside A, lobetyol, isolariciresinol, lobetyolin, and atractylenolide III. Treatment with CLP remarkably suppressed the cell proliferation, colony formation, migration, and invasion of A549 cells. Synergistic effects of lobetyolin and lobetyol were equivalent to the antiproliferative activities of CLP, while other compounds did not have any inhibition on the viabilities of A549 cells. CLP also reduced the expression of Ras, PI3K, p-AKT, Bcl-2, cyclin D1, and CDK4 but increased the expression of Bax, GSK-3β, clv-caspase-3, and clv-caspase-9, which could be reversed by the PI3K activator 740YP. Furthermore, CLP retarded the growths of tumor and lung pathogenic bacteria in mice. It demonstrated that lobetyolin and lobetyol were the main antitumor compounds in C. lanceolata. CLP induced cell apoptosis of lung cancer cells via inactivation of the Ras/PI3K/AKT pathway and ameliorated lung dysbiosis, suggesting the therapeutic potentials for treating human lung cancer.

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The Composition Alteration of Respiratory Microbiota in Lung Cancer

Cited by 12 publications

References 60 publications

Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer

Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer

Smoking has disruptive effects on the small bowel luminal microbiome

Polyacetylenes from Codonopsis lanceolata Root Induced Apoptosis of Human Lung Adenocarcinoma Cells and Improved Lung Dysbiosis

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