The concentration of ammonia in blood and plasma stored for transfusion

Red blood cell storage lesion

“…Ammonia concentration increases with time in both human and canine stored RBC products . Human RBCs are rich in ammonia containing three times more ammonia than that found in the plasma .…”

Biochemical evaluation of the effects of storage on feline erythrocytes

“…Several studies have evaluated ammonia concentrations in packed red blood cells in humans and dogs (Prytz et al . 1970, Barta & Babusikova 1982, Waddell et al . 2001.…”

“…2015, Orlov & Karkouti 2015. Biochemical changes associated with storage are well documented in human medicine and include decreased adenosine triphosphate, decreased 2,3-diphosphoglycerate (2,3-DPG), decreased pH, increased potassium in the supernatant ttp://www.bsava.com/ 638 Journal of Small Animal Practice • Vol 57 • November 2016 • © 2016 British Small Animal Veterinary Association and increased ammonia concentrations (Barta & Babusikova 1982, d ' Almeida et al . 2000, Adias et al .…”

Hyperammonemia as a Marker of Subclinical Seizures After Traumatic Cardiac Arrest

“…Acidosis can inhibit the glycolysis pathway in red blood cells, thereby leading to an accumulation of ammonia in the blood (2). Barta and Babusikova suggested that ammonia in cardiac arrest patients was produced mainly in red blood cells due to acidosis and hypoxia (3). Lin et al investigated the association between elevated blood ammonia and partial pressure of ammonia seen in out of hospital cardiac arrest patients and their return to spontaneous circulation (ROSC).…”